4XES

Structure of active-like neurotensin receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue CIT A 1201

Chain	Residue
A	ARG299
A	SER1165
A	ARG1008
A	ILE1009
A	PHE1114
A	THR1115
A	ASN1116
A	SER1117
A	ASN1132
A	SER1163

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PEG A 1202

Chain	Residue
A	CYS172
A	LYS263
A	LEU1079
A	PEG1203

---

site_id	AC3
Number of Residues	6
Details	binding site for residue PEG A 1203

Chain	Residue
A	LYS263
A	MET267
A	VAL1075
A	TYR1088
A	ARG1096
A	PEG1202

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PEG A 1204

Chain	Residue
A	LEU303
A	PHE1004
A	ASN1068

---

site_id	AC5
Number of Residues	8
Details	binding site for residue PEG A 1206

Chain	Residue
A	ARG1080
A	ASN1081
A	ALA1082
A	GLU1108
A	THR1109
A	TYR1139
A	PRO1143
A	ASN1144

---

site_id	AC6
Number of Residues	2
Details	binding site for residue GOL A 1207

Chain	Residue
A	ARG1125
B	ARG8

---

site_id	AC7
Number of Residues	1
Details	binding site for residue GOL A 1208

Chain	Residue
A	TYR349

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL A 1209

Chain	Residue
A	LYS1083
A	THR1142
A	PRO1143
A	ASN1144
A	ARG1145

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EPE A 1210

Chain	Residue
A	GLY1030
A	HIS1031
A	LEU1032
A	LYS1035
A	ASP1070
A	PHE1104
A	MET1106
A	ASP1159

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EPE A 1211

Chain	Residue
A	ASP56
A	VAL57
A	TRP130
A	HIS132
A	HIS133

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04110","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1892846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3382407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8266098","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7831309","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	32
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24453215","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	64
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24453215","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	23
Details	Region: {"description":"Neurotensin binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Site: {"description":"Cleavage; by MME","evidences":[{"source":"UniProtKB","id":"P30990","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Site: {"description":"Cleavage; by ACE and MME","evidences":[{"source":"UniProtKB","id":"P30990","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASP1020	covalent catalysis

---