4XE5
Crystal structure of the Na,K-ATPase from bovine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002028 | biological_process | regulation of sodium ion transport |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005391 | molecular_function | P-type sodium:potassium-exchanging transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006883 | biological_process | intracellular sodium ion homeostasis |
| A | 0008556 | molecular_function | P-type potassium transmembrane transporter activity |
| A | 0010248 | biological_process | establishment or maintenance of transmembrane electrochemical gradient |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030007 | biological_process | intracellular potassium ion homeostasis |
| A | 0030424 | cellular_component | axon |
| A | 0036376 | biological_process | sodium ion export across plasma membrane |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042470 | cellular_component | melanosome |
| A | 0045121 | cellular_component | membrane raft |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0001671 | molecular_function | ATPase activator activity |
| B | 0005391 | molecular_function | P-type sodium:potassium-exchanging transporter activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0006874 | biological_process | intracellular calcium ion homeostasis |
| B | 0006883 | biological_process | intracellular sodium ion homeostasis |
| B | 0010248 | biological_process | establishment or maintenance of transmembrane electrochemical gradient |
| B | 0010468 | biological_process | regulation of gene expression |
| B | 0010882 | biological_process | regulation of cardiac muscle contraction by calcium ion signaling |
| B | 0014704 | cellular_component | intercalated disc |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016328 | cellular_component | lateral plasma membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0030007 | biological_process | intracellular potassium ion homeostasis |
| B | 0030315 | cellular_component | T-tubule |
| B | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| B | 0031090 | cellular_component | organelle membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0036126 | cellular_component | sperm flagellum |
| B | 0036376 | biological_process | sodium ion export across plasma membrane |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0046034 | biological_process | ATP metabolic process |
| B | 0050821 | biological_process | protein stabilization |
| B | 0051117 | molecular_function | ATPase binding |
| B | 0055119 | biological_process | relaxation of cardiac muscle |
| B | 0060048 | biological_process | cardiac muscle contraction |
| B | 0072659 | biological_process | protein localization to plasma membrane |
| B | 0086009 | biological_process | membrane repolarization |
| B | 0141109 | molecular_function | transporter activator activity |
| B | 1903169 | biological_process | regulation of calcium ion transmembrane transport |
| B | 1903278 | biological_process | positive regulation of sodium ion export across plasma membrane |
| B | 1903288 | biological_process | positive regulation of potassium ion import across plasma membrane |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0006813 | biological_process | potassium ion transport |
| G | 0006814 | biological_process | sodium ion transport |
| G | 0016020 | cellular_component | membrane |
| G | 0017080 | molecular_function | sodium channel regulator activity |
| G | 0043269 | biological_process | regulation of monoatomic ion transport |
| G | 0099106 | molecular_function | ion channel regulator activity |
| G | 1903278 | biological_process | positive regulation of sodium ion export across plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 1101 |
| Chain | Residue |
| A | BFD374 |
| A | THR376 |
| A | ASP715 |
| A | HOH1203 |
| A | HOH1204 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 1102 |
| Chain | Residue |
| A | LYS724 |
| A | ASP745 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 1103 |
| Chain | Residue |
| A | GLU784 |
| A | ASP809 |
| A | HOH1201 |
| A | HOH1202 |
| A | HOH1205 |
| A | SER780 |
| A | ASN781 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue OBN A 1104 |
| Chain | Residue |
| A | GLN116 |
| A | GLU122 |
| A | PRO123 |
| A | ASP126 |
| A | LEU130 |
| A | GLU317 |
| A | ALA328 |
| A | GLU332 |
| A | PHE788 |
| A | THR802 |
| A | ILE805 |
| A | ARG885 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CLR A 1105 |
| Chain | Residue |
| A | GLU873 |
| A | THR984 |
| A | PRO991 |
| B | THR53 |
| B | VAL56 |
| B | THR60 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue CLR A 1106 |
| Chain | Residue |
| A | TRP929 |
| A | PRO983 |
| A | TRP986 |
| A | PHE987 |
| A | PHE990 |
| G | VAL14 |
| G | PHE21 |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | BFD374-THR380 |
| site_id | PS00390 |
| Number of Residues | 21 |
| Details | ATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFiWNsekkefLGRTggsW |
| Chain | Residue | Details |
| B | TRP12-TRP32 |
| site_id | PS00391 |
| Number of Residues | 16 |
| Details | ATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. RkvCRfklewLgnCSG |
| Chain | Residue | Details |
| B | ARG146-GLY161 |
| site_id | PS01310 |
| Number of Residues | 14 |
| Details | FXYD FXYD family signature. DpFyYDyeTVRngG |
| Chain | Residue | Details |
| G | ASP5-GLY18 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 213 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 107 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 166 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Region: {"description":"Phosphoinositide-3 kinase binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 121 |
| Details | Region: {"description":"Mediates interaction with SCN7A","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06685","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05023","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"P06685","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
