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4XE5

Crystal structure of the Na,K-ATPase from bovine

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002028biological_processregulation of sodium ion transport
A0005215molecular_functiontransporter activity
A0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0005890cellular_componentsodium:potassium-exchanging ATPase complex
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0006883biological_processintracellular sodium ion homeostasis
A0008556molecular_functionP-type potassium transmembrane transporter activity
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0030007biological_processintracellular potassium ion homeostasis
A0030424cellular_componentaxon
A0036376biological_processsodium ion export across plasma membrane
A0042383cellular_componentsarcolemma
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0045121cellular_componentmembrane raft
A0046872molecular_functionmetal ion binding
A1902600biological_processproton transmembrane transport
A1990573biological_processpotassium ion import across plasma membrane
B0001671molecular_functionATPase activator activity
B0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
B0005886cellular_componentplasma membrane
B0005890cellular_componentsodium:potassium-exchanging ATPase complex
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006883biological_processintracellular sodium ion homeostasis
B0007155biological_processcell adhesion
B0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
B0010468biological_processregulation of gene expression
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014704cellular_componentintercalated disc
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0019901molecular_functionprotein kinase binding
B0030007biological_processintracellular potassium ion homeostasis
B0030315cellular_componentT-tubule
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031090cellular_componentorganelle membrane
B0032781biological_processpositive regulation of ATP-dependent activity
B0035725biological_processsodium ion transmembrane transport
B0036126cellular_componentsperm flagellum
B0036376biological_processsodium ion export across plasma membrane
B0042383cellular_componentsarcolemma
B0046034biological_processATP metabolic process
B0050821biological_processprotein stabilization
B0051117molecular_functionATPase binding
B0055119biological_processrelaxation of cardiac muscle
B0060048biological_processcardiac muscle contraction
B0072659biological_processprotein localization to plasma membrane
B0086009biological_processmembrane repolarization
B0098655biological_processmonoatomic cation transmembrane transport
B1901018biological_processpositive regulation of potassium ion transmembrane transporter activity
B1903169biological_processregulation of calcium ion transmembrane transport
B1903278biological_processpositive regulation of sodium ion export across plasma membrane
B1903288biological_processpositive regulation of potassium ion import across plasma membrane
B1903408biological_processpositive regulation of P-type sodium:potassium-exchanging transporter activity
B1990573biological_processpotassium ion import across plasma membrane
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0006814biological_processsodium ion transport
G0016020cellular_componentmembrane
G0017080molecular_functionsodium channel regulator activity
G0043269biological_processregulation of monoatomic ion transport
G0099106molecular_functionion channel regulator activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MG A 1101
ChainResidue
ABFD374
ATHR376
AASP715
AHOH1203
AHOH1204

site_idAC2
Number of Residues2
Detailsbinding site for residue MG A 1102
ChainResidue
ALYS724
AASP745

site_idAC3
Number of Residues7
Detailsbinding site for residue MG A 1103
ChainResidue
AGLU784
AASP809
AHOH1201
AHOH1202
AHOH1205
ASER780
AASN781

site_idAC4
Number of Residues12
Detailsbinding site for residue OBN A 1104
ChainResidue
AGLN116
AGLU122
APRO123
AASP126
ALEU130
AGLU317
AALA328
AGLU332
APHE788
ATHR802
AILE805
AARG885

site_idAC5
Number of Residues6
Detailsbinding site for residue CLR A 1105
ChainResidue
AGLU873
ATHR984
APRO991
BTHR53
BVAL56
BTHR60

site_idAC6
Number of Residues7
Detailsbinding site for residue CLR A 1106
ChainResidue
ATRP929
APRO983
ATRP986
APHE987
APHE990
GVAL14
GPHE21

Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
ABFD374-THR380

site_idPS00390
Number of Residues21
DetailsATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFiWNsekkefLGRTggsW
ChainResidueDetails
BTRP12-TRP32

site_idPS00391
Number of Residues16
DetailsATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. RkvCRfklewLgnCSG
ChainResidueDetails
BARG146-GLY161

site_idPS01310
Number of Residues14
DetailsFXYD FXYD family signature. DpFyYDyeTVRngG
ChainResidueDetails
GASP5-GLY18

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues19
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
GASN16-SER35
ALYS151-ILE286
ATHR337-LEU770
ATYR822-LYS841
ATHR937-ASN949
ALEU1005-TYR1021

site_idSWS_FT_FI2
Number of Residues194
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AGLU86-ALA106
ATHR984-LYS1004
ALEU130-ALA150
AGLU287-ILE306
AVAL319-ALA336
ALYS771-ILE790
AGLY801-ALA821
ALEU842-PHE864
AHIS917-LYS936
ALYS950-TYR968

site_idSWS_FT_FI3
Number of Residues107
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AVAL107-TYR129
ALEU307-ALA318
APHE791-LEU800
APHE865-CYS916
ACYS969-PRO983

site_idSWS_FT_FI4
Number of Residues1
DetailsACT_SITE: 4-aspartylphosphate intermediate => ECO:0000250
ChainResidueDetails
ABFD374

site_idSWS_FT_FI5
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALYS485
AASP715
AASP719

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ALYS9
ALYS21

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ATYR10

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ASER16

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ASER38
ASER45
ASER450
ASER482

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ASER226
ASER666

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8VDN2
ChainResidueDetails
ATYR258

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05023
ChainResidueDetails
ATYR540

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P06685
ChainResidueDetails
ASER941

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PDB entries from 2024-10-16

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