4XCS

Human peroxiredoxin-1 C83S mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0001501	biological_process	skeletal system development
A	0003723	molecular_function	RNA binding
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0007249	biological_process	canonical NF-kappaB signal transduction
A	0008283	biological_process	cell population proliferation
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0030101	biological_process	natural killer cell activation
A	0032872	biological_process	regulation of stress-activated MAPK cascade
A	0034101	biological_process	erythrocyte homeostasis
A	0042267	biological_process	natural killer cell mediated cytotoxicity
A	0042470	cellular_component	melanosome
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045296	molecular_function	cadherin binding
A	0045321	biological_process	leukocyte activation
A	0045454	biological_process	cell redox homeostasis
A	0048144	biological_process	fibroblast proliferation
A	0051920	molecular_function	peroxiredoxin activity
A	0070062	cellular_component	extracellular exosome
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
A	1901222	biological_process	regulation of non-canonical NF-kappaB signal transduction
B	0000302	biological_process	response to reactive oxygen species
B	0001501	biological_process	skeletal system development
B	0003723	molecular_function	RNA binding
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0007249	biological_process	canonical NF-kappaB signal transduction
B	0008283	biological_process	cell population proliferation
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0030101	biological_process	natural killer cell activation
B	0032872	biological_process	regulation of stress-activated MAPK cascade
B	0034101	biological_process	erythrocyte homeostasis
B	0042267	biological_process	natural killer cell mediated cytotoxicity
B	0042470	cellular_component	melanosome
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045296	molecular_function	cadherin binding
B	0045321	biological_process	leukocyte activation
B	0045454	biological_process	cell redox homeostasis
B	0048144	biological_process	fibroblast proliferation
B	0051920	molecular_function	peroxiredoxin activity
B	0070062	cellular_component	extracellular exosome
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	1901222	biological_process	regulation of non-canonical NF-kappaB signal transduction
C	0000302	biological_process	response to reactive oxygen species
C	0001501	biological_process	skeletal system development
C	0003723	molecular_function	RNA binding
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0007249	biological_process	canonical NF-kappaB signal transduction
C	0008283	biological_process	cell population proliferation
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0030101	biological_process	natural killer cell activation
C	0032872	biological_process	regulation of stress-activated MAPK cascade
C	0034101	biological_process	erythrocyte homeostasis
C	0042267	biological_process	natural killer cell mediated cytotoxicity
C	0042470	cellular_component	melanosome
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045296	molecular_function	cadherin binding
C	0045321	biological_process	leukocyte activation
C	0045454	biological_process	cell redox homeostasis
C	0048144	biological_process	fibroblast proliferation
C	0051920	molecular_function	peroxiredoxin activity
C	0070062	cellular_component	extracellular exosome
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	1901222	biological_process	regulation of non-canonical NF-kappaB signal transduction
D	0000302	biological_process	response to reactive oxygen species
D	0001501	biological_process	skeletal system development
D	0003723	molecular_function	RNA binding
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0007249	biological_process	canonical NF-kappaB signal transduction
D	0008283	biological_process	cell population proliferation
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0030101	biological_process	natural killer cell activation
D	0032872	biological_process	regulation of stress-activated MAPK cascade
D	0034101	biological_process	erythrocyte homeostasis
D	0042267	biological_process	natural killer cell mediated cytotoxicity
D	0042470	cellular_component	melanosome
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045296	molecular_function	cadherin binding
D	0045321	biological_process	leukocyte activation
D	0045454	biological_process	cell redox homeostasis
D	0048144	biological_process	fibroblast proliferation
D	0051920	molecular_function	peroxiredoxin activity
D	0070062	cellular_component	extracellular exosome
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	1901222	biological_process	regulation of non-canonical NF-kappaB signal transduction
E	0000302	biological_process	response to reactive oxygen species
E	0001501	biological_process	skeletal system development
E	0003723	molecular_function	RNA binding
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0007249	biological_process	canonical NF-kappaB signal transduction
E	0008283	biological_process	cell population proliferation
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0019430	biological_process	removal of superoxide radicals
E	0030101	biological_process	natural killer cell activation
E	0032872	biological_process	regulation of stress-activated MAPK cascade
E	0034101	biological_process	erythrocyte homeostasis
E	0042267	biological_process	natural killer cell mediated cytotoxicity
E	0042470	cellular_component	melanosome
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045296	molecular_function	cadherin binding
E	0045321	biological_process	leukocyte activation
E	0045454	biological_process	cell redox homeostasis
E	0048144	biological_process	fibroblast proliferation
E	0051920	molecular_function	peroxiredoxin activity
E	0070062	cellular_component	extracellular exosome
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	1901222	biological_process	regulation of non-canonical NF-kappaB signal transduction
F	0000302	biological_process	response to reactive oxygen species
F	0001501	biological_process	skeletal system development
F	0003723	molecular_function	RNA binding
F	0004601	molecular_function	peroxidase activity
F	0005515	molecular_function	protein binding
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0007249	biological_process	canonical NF-kappaB signal transduction
F	0008283	biological_process	cell population proliferation
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0019430	biological_process	removal of superoxide radicals
F	0030101	biological_process	natural killer cell activation
F	0032872	biological_process	regulation of stress-activated MAPK cascade
F	0034101	biological_process	erythrocyte homeostasis
F	0042267	biological_process	natural killer cell mediated cytotoxicity
F	0042470	cellular_component	melanosome
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042802	molecular_function	identical protein binding
F	0045296	molecular_function	cadherin binding
F	0045321	biological_process	leukocyte activation
F	0045454	biological_process	cell redox homeostasis
F	0048144	biological_process	fibroblast proliferation
F	0051920	molecular_function	peroxiredoxin activity
F	0070062	cellular_component	extracellular exosome
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	1901222	biological_process	regulation of non-canonical NF-kappaB signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 201

Chain	Residue
A	ARG128
A	LEU130
A	THR143
A	ASN145
A	ARG151
A	HOH333
A	HOH357

---

site_id	AC2
Number of Residues	10
Details	binding site for residue CPS A 202

Chain	Residue
A	LYS93
A	GLY95
A	HOH356
B	GLY176
B	TRP177
B	LYS178
B	PRO179
B	HOH217
A	THR90
A	LYS92

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL C 201

Chain	Residue
C	ARG128
C	LEU130
C	THR143
C	ASN145
C	ARG151
C	HOH345
C	HOH378

---

site_id	AC4
Number of Residues	13
Details	binding site for residue CPS D 201

Chain	Residue
C	TRP87
C	THR90
C	LYS92
C	LYS93
C	GLN94
C	GLY95
C	HOH310
D	GLY176
D	TRP177
D	LYS178
D	HOH325
D	HOH337
E	LYS109

---

site_id	AC5
Number of Residues	11
Details	binding site for residue CPS E 201

Chain	Residue
E	GLY176
E	TRP177
E	LYS178
E	PRO179
E	HOH304
E	HOH314
E	HOH338
F	THR90
F	LYS92
F	LYS93
F	GLY95

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL F 201

Chain	Residue
F	ARG128
F	GLY129
F	LEU130
F	ASN145
F	ARG151
F	HOH326
F	HOH344

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	954
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"12059788","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"12161445","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P35700","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine; by CDK1","evidences":[{"source":"PubMed","id":"11986303","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P35700","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---