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4XCS

Human peroxiredoxin-1 C83S mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0001501biological_processskeletal system development
A0003723molecular_functionRNA binding
A0004601molecular_functionperoxidase activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006979biological_processresponse to oxidative stress
A0007249biological_processcanonical NF-kappaB signal transduction
A0008283biological_processcell population proliferation
A0008379molecular_functionthioredoxin peroxidase activity
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0019430biological_processremoval of superoxide radicals
A0030101biological_processnatural killer cell activation
A0032872biological_processregulation of stress-activated MAPK cascade
A0033554biological_processcellular response to stress
A0034101biological_processerythrocyte homeostasis
A0042267biological_processnatural killer cell mediated cytotoxicity
A0042470cellular_componentmelanosome
A0042744biological_processhydrogen peroxide catabolic process
A0042802molecular_functionidentical protein binding
A0045296molecular_functioncadherin binding
A0045321biological_processleukocyte activation
A0045454biological_processcell redox homeostasis
A0048144biological_processfibroblast proliferation
A0051920molecular_functionperoxiredoxin activity
A0070062cellular_componentextracellular exosome
A0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
A1901222biological_processregulation of non-canonical NF-kappaB signal transduction
B0000302biological_processresponse to reactive oxygen species
B0001501biological_processskeletal system development
B0003723molecular_functionRNA binding
B0004601molecular_functionperoxidase activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006979biological_processresponse to oxidative stress
B0007249biological_processcanonical NF-kappaB signal transduction
B0008283biological_processcell population proliferation
B0008379molecular_functionthioredoxin peroxidase activity
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0019430biological_processremoval of superoxide radicals
B0030101biological_processnatural killer cell activation
B0032872biological_processregulation of stress-activated MAPK cascade
B0033554biological_processcellular response to stress
B0034101biological_processerythrocyte homeostasis
B0042267biological_processnatural killer cell mediated cytotoxicity
B0042470cellular_componentmelanosome
B0042744biological_processhydrogen peroxide catabolic process
B0042802molecular_functionidentical protein binding
B0045296molecular_functioncadherin binding
B0045321biological_processleukocyte activation
B0045454biological_processcell redox homeostasis
B0048144biological_processfibroblast proliferation
B0051920molecular_functionperoxiredoxin activity
B0070062cellular_componentextracellular exosome
B0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
B1901222biological_processregulation of non-canonical NF-kappaB signal transduction
C0000302biological_processresponse to reactive oxygen species
C0001501biological_processskeletal system development
C0003723molecular_functionRNA binding
C0004601molecular_functionperoxidase activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006979biological_processresponse to oxidative stress
C0007249biological_processcanonical NF-kappaB signal transduction
C0008283biological_processcell population proliferation
C0008379molecular_functionthioredoxin peroxidase activity
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0019430biological_processremoval of superoxide radicals
C0030101biological_processnatural killer cell activation
C0032872biological_processregulation of stress-activated MAPK cascade
C0033554biological_processcellular response to stress
C0034101biological_processerythrocyte homeostasis
C0042267biological_processnatural killer cell mediated cytotoxicity
C0042470cellular_componentmelanosome
C0042744biological_processhydrogen peroxide catabolic process
C0042802molecular_functionidentical protein binding
C0045296molecular_functioncadherin binding
C0045321biological_processleukocyte activation
C0045454biological_processcell redox homeostasis
C0048144biological_processfibroblast proliferation
C0051920molecular_functionperoxiredoxin activity
C0070062cellular_componentextracellular exosome
C0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
C1901222biological_processregulation of non-canonical NF-kappaB signal transduction
D0000302biological_processresponse to reactive oxygen species
D0001501biological_processskeletal system development
D0003723molecular_functionRNA binding
D0004601molecular_functionperoxidase activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006979biological_processresponse to oxidative stress
D0007249biological_processcanonical NF-kappaB signal transduction
D0008283biological_processcell population proliferation
D0008379molecular_functionthioredoxin peroxidase activity
D0016209molecular_functionantioxidant activity
D0016491molecular_functionoxidoreductase activity
D0019430biological_processremoval of superoxide radicals
D0030101biological_processnatural killer cell activation
D0032872biological_processregulation of stress-activated MAPK cascade
D0033554biological_processcellular response to stress
D0034101biological_processerythrocyte homeostasis
D0042267biological_processnatural killer cell mediated cytotoxicity
D0042470cellular_componentmelanosome
D0042744biological_processhydrogen peroxide catabolic process
D0042802molecular_functionidentical protein binding
D0045296molecular_functioncadherin binding
D0045321biological_processleukocyte activation
D0045454biological_processcell redox homeostasis
D0048144biological_processfibroblast proliferation
D0051920molecular_functionperoxiredoxin activity
D0070062cellular_componentextracellular exosome
D0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
D1901222biological_processregulation of non-canonical NF-kappaB signal transduction
E0000302biological_processresponse to reactive oxygen species
E0001501biological_processskeletal system development
E0003723molecular_functionRNA binding
E0004601molecular_functionperoxidase activity
E0005515molecular_functionprotein binding
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006979biological_processresponse to oxidative stress
E0007249biological_processcanonical NF-kappaB signal transduction
E0008283biological_processcell population proliferation
E0008379molecular_functionthioredoxin peroxidase activity
E0016209molecular_functionantioxidant activity
E0016491molecular_functionoxidoreductase activity
E0019430biological_processremoval of superoxide radicals
E0030101biological_processnatural killer cell activation
E0032872biological_processregulation of stress-activated MAPK cascade
E0033554biological_processcellular response to stress
E0034101biological_processerythrocyte homeostasis
E0042267biological_processnatural killer cell mediated cytotoxicity
E0042470cellular_componentmelanosome
E0042744biological_processhydrogen peroxide catabolic process
E0042802molecular_functionidentical protein binding
E0045296molecular_functioncadherin binding
E0045321biological_processleukocyte activation
E0045454biological_processcell redox homeostasis
E0048144biological_processfibroblast proliferation
E0051920molecular_functionperoxiredoxin activity
E0070062cellular_componentextracellular exosome
E0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
E1901222biological_processregulation of non-canonical NF-kappaB signal transduction
F0000302biological_processresponse to reactive oxygen species
F0001501biological_processskeletal system development
F0003723molecular_functionRNA binding
F0004601molecular_functionperoxidase activity
F0005515molecular_functionprotein binding
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006979biological_processresponse to oxidative stress
F0007249biological_processcanonical NF-kappaB signal transduction
F0008283biological_processcell population proliferation
F0008379molecular_functionthioredoxin peroxidase activity
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0019430biological_processremoval of superoxide radicals
F0030101biological_processnatural killer cell activation
F0032872biological_processregulation of stress-activated MAPK cascade
F0033554biological_processcellular response to stress
F0034101biological_processerythrocyte homeostasis
F0042267biological_processnatural killer cell mediated cytotoxicity
F0042470cellular_componentmelanosome
F0042744biological_processhydrogen peroxide catabolic process
F0042802molecular_functionidentical protein binding
F0045296molecular_functioncadherin binding
F0045321biological_processleukocyte activation
F0045454biological_processcell redox homeostasis
F0048144biological_processfibroblast proliferation
F0051920molecular_functionperoxiredoxin activity
F0070062cellular_componentextracellular exosome
F0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
F1901222biological_processregulation of non-canonical NF-kappaB signal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue GOL A 201
ChainResidue
AARG128
ALEU130
ATHR143
AASN145
AARG151
AHOH333
AHOH357

site_idAC2
Number of Residues10
Detailsbinding site for residue CPS A 202
ChainResidue
ALYS93
AGLY95
AHOH356
BGLY176
BTRP177
BLYS178
BPRO179
BHOH217
ATHR90
ALYS92

site_idAC3
Number of Residues7
Detailsbinding site for residue GOL C 201
ChainResidue
CARG128
CLEU130
CTHR143
CASN145
CARG151
CHOH345
CHOH378

site_idAC4
Number of Residues13
Detailsbinding site for residue CPS D 201
ChainResidue
CTRP87
CTHR90
CLYS92
CLYS93
CGLN94
CGLY95
CHOH310
DGLY176
DTRP177
DLYS178
DHOH325
DHOH337
ELYS109

site_idAC5
Number of Residues11
Detailsbinding site for residue CPS E 201
ChainResidue
EGLY176
ETRP177
ELYS178
EPRO179
EHOH304
EHOH314
EHOH338
FTHR90
FLYS92
FLYS93
FGLY95

site_idAC6
Number of Residues7
Detailsbinding site for residue GOL F 201
ChainResidue
FARG128
FGLY129
FLEU130
FASN145
FARG151
FHOH326
FHOH344

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:12059788, ECO:0000305|PubMed:12161445
ChainResidueDetails
ACYS52
BCYS52
CCYS52
DCYS52
ECYS52
FCYS52

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:25944712
ChainResidueDetails
ASER2
BSER2
CSER2
DSER2
ESER2
FSER2

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS7
BLYS7
CLYS7
DLYS7
ELYS7
FLYS7

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS16
ELYS27
FLYS16
FLYS27
ALYS27
BLYS16
BLYS27
CLYS16
CLYS27
DLYS16
DLYS27
ELYS16

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER32
BSER32
CSER32
DSER32
ESER32
FSER32

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P35700
ChainResidueDetails
ALYS35
BLYS35
CLYS35
DLYS35
ELYS35
FLYS35

site_idSWS_FT_FI7
Number of Residues6
DetailsMOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:11986303
ChainResidueDetails
ATHR90
BTHR90
CTHR90
DTHR90
ETHR90
FTHR90

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P35700
ChainResidueDetails
ALYS136
BLYS136
CLYS136
DLYS136
ELYS136
FLYS136

site_idSWS_FT_FI9
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS7
BLYS7
CLYS7
DLYS7
ELYS7
FLYS7

site_idSWS_FT_FI10
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0007744|PubMed:25114211
ChainResidueDetails
ELYS185
FLYS185
ALYS185
BLYS185
CLYS185
DLYS185

site_idSWS_FT_FI11
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS120
BLYS120
CLYS120
DLYS120
ELYS120
FLYS120

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PDB entries from 2024-10-30

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