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4X96

Low resolution crystal structure of Lecithin:Cholesterol Acyltransferase (LCAT; residues 21-397)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
A0004607molecular_functionphosphatidylcholine-sterol O-acyltransferase activity
A0004771molecular_functionsterol esterase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006629biological_processlipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006656biological_processphosphatidylcholine biosynthetic process
A0008203biological_processcholesterol metabolic process
A0008374molecular_functionO-acyltransferase activity
A0016746molecular_functionacyltransferase activity
A0016787molecular_functionhydrolase activity
A0030301biological_processcholesterol transport
A0034186molecular_functionapolipoprotein A-I binding
A0034364cellular_componenthigh-density lipoprotein particle
A0034372biological_processvery-low-density lipoprotein particle remodeling
A0034375biological_processhigh-density lipoprotein particle remodeling
A0034435biological_processobsolete cholesterol esterification
A0042158biological_processlipoprotein biosynthetic process
A0042632biological_processcholesterol homeostasis
A0043691biological_processreverse cholesterol transport
A0046470biological_processphosphatidylcholine metabolic process
A0047179molecular_functionplatelet-activating factor acetyltransferase activity
A0070062cellular_componentextracellular exosome
A0090107biological_processregulation of high-density lipoprotein particle assembly
B0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
B0004607molecular_functionphosphatidylcholine-sterol O-acyltransferase activity
B0004771molecular_functionsterol esterase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006629biological_processlipid metabolic process
B0006644biological_processphospholipid metabolic process
B0006656biological_processphosphatidylcholine biosynthetic process
B0008203biological_processcholesterol metabolic process
B0008374molecular_functionO-acyltransferase activity
B0016746molecular_functionacyltransferase activity
B0016787molecular_functionhydrolase activity
B0030301biological_processcholesterol transport
B0034186molecular_functionapolipoprotein A-I binding
B0034364cellular_componenthigh-density lipoprotein particle
B0034372biological_processvery-low-density lipoprotein particle remodeling
B0034375biological_processhigh-density lipoprotein particle remodeling
B0034435biological_processobsolete cholesterol esterification
B0042158biological_processlipoprotein biosynthetic process
B0042632biological_processcholesterol homeostasis
B0043691biological_processreverse cholesterol transport
B0046470biological_processphosphatidylcholine metabolic process
B0047179molecular_functionplatelet-activating factor acetyltransferase activity
B0070062cellular_componentextracellular exosome
B0090107biological_processregulation of high-density lipoprotein particle assembly
C0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
C0004607molecular_functionphosphatidylcholine-sterol O-acyltransferase activity
C0004771molecular_functionsterol esterase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006629biological_processlipid metabolic process
C0006644biological_processphospholipid metabolic process
C0006656biological_processphosphatidylcholine biosynthetic process
C0008203biological_processcholesterol metabolic process
C0008374molecular_functionO-acyltransferase activity
C0016746molecular_functionacyltransferase activity
C0016787molecular_functionhydrolase activity
C0030301biological_processcholesterol transport
C0034186molecular_functionapolipoprotein A-I binding
C0034364cellular_componenthigh-density lipoprotein particle
C0034372biological_processvery-low-density lipoprotein particle remodeling
C0034375biological_processhigh-density lipoprotein particle remodeling
C0034435biological_processobsolete cholesterol esterification
C0042158biological_processlipoprotein biosynthetic process
C0042632biological_processcholesterol homeostasis
C0043691biological_processreverse cholesterol transport
C0046470biological_processphosphatidylcholine metabolic process
C0047179molecular_functionplatelet-activating factor acetyltransferase activity
C0070062cellular_componentextracellular exosome
C0090107biological_processregulation of high-density lipoprotein particle assembly
D0003847molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity
D0004607molecular_functionphosphatidylcholine-sterol O-acyltransferase activity
D0004771molecular_functionsterol esterase activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006629biological_processlipid metabolic process
D0006644biological_processphospholipid metabolic process
D0006656biological_processphosphatidylcholine biosynthetic process
D0008203biological_processcholesterol metabolic process
D0008374molecular_functionO-acyltransferase activity
D0016746molecular_functionacyltransferase activity
D0016787molecular_functionhydrolase activity
D0030301biological_processcholesterol transport
D0034186molecular_functionapolipoprotein A-I binding
D0034364cellular_componenthigh-density lipoprotein particle
D0034372biological_processvery-low-density lipoprotein particle remodeling
D0034375biological_processhigh-density lipoprotein particle remodeling
D0034435biological_processobsolete cholesterol esterification
D0042158biological_processlipoprotein biosynthetic process
D0042632biological_processcholesterol homeostasis
D0043691biological_processreverse cholesterol transport
D0046470biological_processphosphatidylcholine metabolic process
D0047179molecular_functionplatelet-activating factor acetyltransferase activity
D0070062cellular_componentextracellular exosome
D0090107biological_processregulation of high-density lipoprotein particle assembly
Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. VFLIGHSLGC
ChainResidueDetails
DVAL175-CYS184

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000305|PubMed:26195816
ChainResidueDetails
DSER181
ASER181
BSER181
CSER181

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:26195816
ChainResidueDetails
DASP345
DHIS377
AASP345
AHIS377
BASP345
BHIS377
CASP345
CHIS377

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Determinant for substrate specificity => ECO:0000305|PubMed:14636062
ChainResidueDetails
DGLU149
AGLU149
BGLU149
CGLU149

site_idSWS_FT_FI4
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:7613477, ECO:0007744|PDB:4X96
ChainResidueDetails
DASN84
DASN384
AASN84
AASN384
BASN84
BASN384
CASN84
CASN384

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:26195816, ECO:0000269|PubMed:7613477, ECO:0007744|PDB:4X96
ChainResidueDetails
DASN272
AASN272
BASN272
CASN272

222415

PDB entries from 2024-07-10

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