4X94

Crystal structure of Lysosomal Phospholipase A2 crystallized in the presence of methyl arachidonyl fluorophosphonate (hexagonal form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
A	0004623	molecular_function	phospholipase A2 activity
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005654	cellular_component	nucleoplasm
A	0005764	cellular_component	lysosome
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006650	biological_process	glycerophospholipid metabolic process
A	0006651	biological_process	diacylglycerol biosynthetic process
A	0006658	biological_process	phosphatidylserine metabolic process
A	0006672	biological_process	ceramide metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008374	molecular_function	O-acyltransferase activity
A	0008970	molecular_function	phospholipase A1 activity
A	0009062	biological_process	fatty acid catabolic process
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016411	molecular_function	acylglycerol O-acyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0046338	biological_process	phosphatidylethanolamine catabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047499	molecular_function	calcium-independent phospholipase A2 activity
A	0070062	cellular_component	extracellular exosome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25727495","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X97","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"25727495","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25727495","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4X97","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30830753","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25727495","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4X95","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25727495","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X93","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X97","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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