Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4X90

Crystal structure of Lysosomal Phospholipase A2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	lysophospholipase activity
A	0004623	molecular_function	phospholipase A2 activity
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005654	cellular_component	nucleoplasm
A	0005764	cellular_component	lysosome
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006650	biological_process	glycerophospholipid metabolic process
A	0006651	biological_process	diacylglycerol biosynthetic process
A	0006658	biological_process	phosphatidylserine metabolic process
A	0006672	biological_process	ceramide metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008374	molecular_function	O-acyltransferase activity
A	0008970	molecular_function	phospholipase A1 activity
A	0009062	biological_process	fatty acid catabolic process
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016411	molecular_function	acylglycerol O-acyltransferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046338	biological_process	phosphatidylethanolamine catabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0047499	molecular_function	calcium-independent phospholipase A2 activity
A	0052739	molecular_function	phosphatidylserine 1-acylhydrolase activity
A	0070062	cellular_component	extracellular exosome
B	0004622	molecular_function	lysophospholipase activity
B	0004623	molecular_function	phospholipase A2 activity
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005654	cellular_component	nucleoplasm
B	0005764	cellular_component	lysosome
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006644	biological_process	phospholipid metabolic process
B	0006650	biological_process	glycerophospholipid metabolic process
B	0006651	biological_process	diacylglycerol biosynthetic process
B	0006658	biological_process	phosphatidylserine metabolic process
B	0006672	biological_process	ceramide metabolic process
B	0008270	molecular_function	zinc ion binding
B	0008374	molecular_function	O-acyltransferase activity
B	0008970	molecular_function	phospholipase A1 activity
B	0009062	biological_process	fatty acid catabolic process
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016411	molecular_function	acylglycerol O-acyltransferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0034638	biological_process	phosphatidylcholine catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046338	biological_process	phosphatidylethanolamine catabolic process
B	0046470	biological_process	phosphatidylcholine metabolic process
B	0046471	biological_process	phosphatidylglycerol metabolic process
B	0046872	molecular_function	metal ion binding
B	0047498	molecular_function	calcium-dependent phospholipase A2 activity
B	0047499	molecular_function	calcium-independent phospholipase A2 activity
B	0052739	molecular_function	phosphatidylserine 1-acylhydrolase activity
B	0070062	cellular_component	extracellular exosome
C	0004622	molecular_function	lysophospholipase activity
C	0004623	molecular_function	phospholipase A2 activity
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005654	cellular_component	nucleoplasm
C	0005764	cellular_component	lysosome
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006644	biological_process	phospholipid metabolic process
C	0006650	biological_process	glycerophospholipid metabolic process
C	0006651	biological_process	diacylglycerol biosynthetic process
C	0006658	biological_process	phosphatidylserine metabolic process
C	0006672	biological_process	ceramide metabolic process
C	0008270	molecular_function	zinc ion binding
C	0008374	molecular_function	O-acyltransferase activity
C	0008970	molecular_function	phospholipase A1 activity
C	0009062	biological_process	fatty acid catabolic process
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016411	molecular_function	acylglycerol O-acyltransferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016787	molecular_function	hydrolase activity
C	0034638	biological_process	phosphatidylcholine catabolic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046338	biological_process	phosphatidylethanolamine catabolic process
C	0046470	biological_process	phosphatidylcholine metabolic process
C	0046471	biological_process	phosphatidylglycerol metabolic process
C	0046872	molecular_function	metal ion binding
C	0047498	molecular_function	calcium-dependent phospholipase A2 activity
C	0047499	molecular_function	calcium-independent phospholipase A2 activity
C	0052739	molecular_function	phosphatidylserine 1-acylhydrolase activity
C	0070062	cellular_component	extracellular exosome
D	0004622	molecular_function	lysophospholipase activity
D	0004623	molecular_function	phospholipase A2 activity
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005654	cellular_component	nucleoplasm
D	0005764	cellular_component	lysosome
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006644	biological_process	phospholipid metabolic process
D	0006650	biological_process	glycerophospholipid metabolic process
D	0006651	biological_process	diacylglycerol biosynthetic process
D	0006658	biological_process	phosphatidylserine metabolic process
D	0006672	biological_process	ceramide metabolic process
D	0008270	molecular_function	zinc ion binding
D	0008374	molecular_function	O-acyltransferase activity
D	0008970	molecular_function	phospholipase A1 activity
D	0009062	biological_process	fatty acid catabolic process
D	0016020	cellular_component	membrane
D	0016042	biological_process	lipid catabolic process
D	0016411	molecular_function	acylglycerol O-acyltransferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016787	molecular_function	hydrolase activity
D	0034638	biological_process	phosphatidylcholine catabolic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046338	biological_process	phosphatidylethanolamine catabolic process
D	0046470	biological_process	phosphatidylcholine metabolic process
D	0046471	biological_process	phosphatidylglycerol metabolic process
D	0046872	molecular_function	metal ion binding
D	0047498	molecular_function	calcium-dependent phospholipase A2 activity
D	0047499	molecular_function	calcium-independent phospholipase A2 activity
D	0052739	molecular_function	phosphatidylserine 1-acylhydrolase activity
D	0070062	cellular_component	extracellular exosome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000255, ECO:0000269\|PubMed:25727495, ECO:0007744\|PDB:4X97

Chain	Residue	Details
A	SER165
B	SER165
C	SER165
D	SER165

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Charge relay system => ECO:0000305\|PubMed:25727495

Chain	Residue	Details
A	ASP327
A	HIS359
B	ASP327
B	HIS359
C	ASP327
C	HIS359
D	ASP327
D	HIS359

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:25727495, ECO:0007744\|PDB:4X97

Chain	Residue	Details
A	ASP13
B	ASP13
C	ASP13
D	ASP13

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:30830753

Chain	Residue	Details
A	SER165
C	ASP307
C	CYS322
C	HIS359
D	SER165
D	ASP307
D	CYS322
D	HIS359
A	ASP307
A	CYS322
A	HIS359
B	SER165
B	ASP307
B	CYS322
B	HIS359
C	SER165

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:25727495, ECO:0007744\|PDB:4X95

Chain	Residue	Details
A	MET166
B	MET166
C	MET166
D	MET166

site_id	SWS_FT_FI6
Number of Residues	16
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269\|PubMed:25727495, ECO:0007744\|PDB:4X90, ECO:0007744\|PDB:4X91, ECO:0007744\|PDB:4X92, ECO:0007744\|PDB:4X93, ECO:0007744\|PDB:4X94, ECO:0007744\|PDB:4X95, ECO:0007744\|PDB:4X97

Chain	Residue	Details
A	ASN66
C	ASN240
C	ASN256
C	ASN365
D	ASN66
D	ASN240
D	ASN256
D	ASN365
A	ASN240
A	ASN256
A	ASN365
B	ASN66
B	ASN240
B	ASN256
B	ASN365
C	ASN66

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)