4X7Q

PIM2 kinase in complex with Compound 1s

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0007346	biological_process	regulation of mitotic cell cycle
A	0008285	biological_process	negative regulation of cell population proliferation
A	0009615	biological_process	response to virus
A	0010508	biological_process	positive regulation of autophagy
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0043066	biological_process	negative regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0050821	biological_process	protein stabilization
A	0106310	molecular_function	protein serine kinase activity
B	0000082	biological_process	G1/S transition of mitotic cell cycle
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006468	biological_process	protein phosphorylation
B	0006915	biological_process	apoptotic process
B	0007346	biological_process	regulation of mitotic cell cycle
B	0008285	biological_process	negative regulation of cell population proliferation
B	0009615	biological_process	response to virus
B	0010508	biological_process	positive regulation of autophagy
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0043066	biological_process	negative regulation of apoptotic process
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0050821	biological_process	protein stabilization
B	0106310	molecular_function	protein serine kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 3YR B 401

Chain	Residue
B	PHE43
B	GLU167
B	LEU170
B	ILE181
B	ASP182
B	VAL46
B	ALA59
B	LYS61
B	LEU116
B	GLU117
B	ARG118
B	ALA122
B	ASP124

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site_id	AC2
Number of Residues	13
Details	binding site for residue 3YR A 401

Chain	Residue
A	PHE43
A	ALA59
A	LYS61
A	LEU116
A	GLU117
A	ARG118
A	ALA122
A	GLU167
A	LEU170
A	ILE181
A	ASP182
A	PO4402
A	HOH529

---

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 A 402

Chain	Residue
A	ASP124
A	GLU167
A	3YR401
B	THR195

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFGTVFaGhrltdrlq..........VAIK

Chain	Residue	Details
B	LEU38-LYS61

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDIKdeNILI

Chain	Residue	Details
B	VAL159-ILE171

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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