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4X51

X-ray structure of mouse interleukin-10 mutant - S1_E8del, C149Y

Functional Information from GO Data
ChainGOidnamespacecontents
A0001817biological_processregulation of cytokine production
A0001818biological_processnegative regulation of cytokine production
A0001819biological_processpositive regulation of cytokine production
A0001938biological_processpositive regulation of endothelial cell proliferation
A0002237biological_processresponse to molecule of bacterial origin
A0002439biological_processchronic inflammatory response to antigenic stimulus
A0002639biological_processpositive regulation of immunoglobulin production
A0002719biological_processnegative regulation of cytokine production involved in immune response
A0002875biological_processnegative regulation of chronic inflammatory response to antigenic stimulus
A0002904biological_processpositive regulation of B cell apoptotic process
A0005125molecular_functioncytokine activity
A0005141molecular_functioninterleukin-10 receptor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0008285biological_processnegative regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010033biological_processobsolete response to organic substance
A0010468biological_processregulation of gene expression
A0010507biological_processnegative regulation of autophagy
A0014823biological_processresponse to activity
A0014854biological_processresponse to inactivity
A0030886biological_processnegative regulation of myeloid dendritic cell activation
A0030889biological_processnegative regulation of B cell proliferation
A0032496biological_processresponse to lipopolysaccharide
A0032689biological_processnegative regulation of type II interferon production
A0032695biological_processnegative regulation of interleukin-12 production
A0032715biological_processnegative regulation of interleukin-6 production
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032868biological_processresponse to insulin
A0034115biological_processnegative regulation of heterotypic cell-cell adhesion
A0034465biological_processresponse to carbon monoxide
A0035729biological_processcellular response to hepatocyte growth factor stimulus
A0042742biological_processdefense response to bacterium
A0042832biological_processdefense response to protozoan
A0043032biological_processpositive regulation of macrophage activation
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0045019biological_processnegative regulation of nitric oxide biosynthetic process
A0045347biological_processnegative regulation of MHC class II biosynthetic process
A0045348biological_processpositive regulation of MHC class II biosynthetic process
A0045787biological_processpositive regulation of cell cycle
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046983molecular_functionprotein dimerization activity
A0050728biological_processnegative regulation of inflammatory response
A0050807biological_processregulation of synapse organization
A0051045biological_processnegative regulation of membrane protein ectodomain proteolysis
A0051384biological_processresponse to glucocorticoid
A0060670biological_processbranching involved in labyrinthine layer morphogenesis
A0071222biological_processcellular response to lipopolysaccharide
A0071392biological_processcellular response to estradiol stimulus
A0097421biological_processliver regeneration
A1900100biological_processpositive regulation of plasma cell differentiation
A1902895biological_processpositive regulation of miRNA transcription
A1903034biological_processregulation of response to wounding
A1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903672biological_processpositive regulation of sprouting angiogenesis
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A2000352biological_processnegative regulation of endothelial cell apoptotic process
B0001817biological_processregulation of cytokine production
B0001818biological_processnegative regulation of cytokine production
B0001819biological_processpositive regulation of cytokine production
B0001938biological_processpositive regulation of endothelial cell proliferation
B0002237biological_processresponse to molecule of bacterial origin
B0002439biological_processchronic inflammatory response to antigenic stimulus
B0002639biological_processpositive regulation of immunoglobulin production
B0002719biological_processnegative regulation of cytokine production involved in immune response
B0002875biological_processnegative regulation of chronic inflammatory response to antigenic stimulus
B0002904biological_processpositive regulation of B cell apoptotic process
B0005125molecular_functioncytokine activity
B0005141molecular_functioninterleukin-10 receptor binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006955biological_processimmune response
B0007165biological_processsignal transduction
B0008285biological_processnegative regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0010033biological_processobsolete response to organic substance
B0010468biological_processregulation of gene expression
B0010507biological_processnegative regulation of autophagy
B0014823biological_processresponse to activity
B0014854biological_processresponse to inactivity
B0030886biological_processnegative regulation of myeloid dendritic cell activation
B0030889biological_processnegative regulation of B cell proliferation
B0032496biological_processresponse to lipopolysaccharide
B0032689biological_processnegative regulation of type II interferon production
B0032695biological_processnegative regulation of interleukin-12 production
B0032715biological_processnegative regulation of interleukin-6 production
B0032720biological_processnegative regulation of tumor necrosis factor production
B0032868biological_processresponse to insulin
B0034115biological_processnegative regulation of heterotypic cell-cell adhesion
B0034465biological_processresponse to carbon monoxide
B0035729biological_processcellular response to hepatocyte growth factor stimulus
B0042742biological_processdefense response to bacterium
B0042832biological_processdefense response to protozoan
B0043032biological_processpositive regulation of macrophage activation
B0043066biological_processnegative regulation of apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0045019biological_processnegative regulation of nitric oxide biosynthetic process
B0045347biological_processnegative regulation of MHC class II biosynthetic process
B0045348biological_processpositive regulation of MHC class II biosynthetic process
B0045787biological_processpositive regulation of cell cycle
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046983molecular_functionprotein dimerization activity
B0050728biological_processnegative regulation of inflammatory response
B0050807biological_processregulation of synapse organization
B0051045biological_processnegative regulation of membrane protein ectodomain proteolysis
B0051384biological_processresponse to glucocorticoid
B0060670biological_processbranching involved in labyrinthine layer morphogenesis
B0071222biological_processcellular response to lipopolysaccharide
B0071392biological_processcellular response to estradiol stimulus
B0097421biological_processliver regeneration
B1900100biological_processpositive regulation of plasma cell differentiation
B1902895biological_processpositive regulation of miRNA transcription
B1903034biological_processregulation of response to wounding
B1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
B1903672biological_processpositive regulation of sprouting angiogenesis
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PROSITE/UniProt
site_idPS00520
Number of Residues21
DetailsINTERLEUKIN_10 Interleukin-10 family signature. KgylgCQalseMIqFYLvEVM
ChainResidueDetails
ALYS57-MET77

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN11
AASN116
BASN11
BASN116

222624

PDB entries from 2024-07-17

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