4X4U

Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a human MenBeta minihelix ending in CCACC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001680	biological_process	tRNA 3'-terminal CCA addition
A	0003723	molecular_function	RNA binding
A	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008033	biological_process	tRNA processing
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	0042245	biological_process	RNA repair
A	0046872	molecular_function	metal ion binding
A	0106354	biological_process	tRNA surveillance
A	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0001680	biological_process	tRNA 3'-terminal CCA addition
C	0003723	molecular_function	RNA binding
C	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
C	0005524	molecular_function	ATP binding
C	0008033	biological_process	tRNA processing
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0031123	biological_process	RNA 3'-end processing
C	0042245	biological_process	RNA repair
C	0046872	molecular_function	metal ion binding
C	0106354	biological_process	tRNA surveillance
C	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
E	0000049	molecular_function	tRNA binding
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001680	biological_process	tRNA 3'-terminal CCA addition
E	0003723	molecular_function	RNA binding
E	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
E	0005524	molecular_function	ATP binding
E	0008033	biological_process	tRNA processing
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0031123	biological_process	RNA 3'-end processing
E	0042245	biological_process	RNA repair
E	0046872	molecular_function	metal ion binding
E	0106354	biological_process	tRNA surveillance
E	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity
F	0000049	molecular_function	tRNA binding
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0001680	biological_process	tRNA 3'-terminal CCA addition
F	0003723	molecular_function	RNA binding
F	0004810	molecular_function	CCA tRNA nucleotidyltransferase activity
F	0005524	molecular_function	ATP binding
F	0008033	biological_process	tRNA processing
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0031123	biological_process	RNA 3'-end processing
F	0042245	biological_process	RNA repair
F	0046872	molecular_function	metal ion binding
F	0106354	biological_process	tRNA surveillance
F	0160016	molecular_function	CCACCA tRNA nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue APC A 501

Chain	Residue
A	GLY46
A	TYR173
A	ARG224
B	C34
B	C36
B	C37
A	SER47
A	ARG50
A	GLU59
A	ASP61
A	THR130
A	HIS133
A	LYS152
A	TYR161

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 502

Chain	Residue
A	GLU311
A	ARG380
A	HOH612

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site_id	AC3
Number of Residues	2
Details	binding site for residue GOL A 503

Chain	Residue
A	VAL355
A	LYS356

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site_id	AC4
Number of Residues	3
Details	binding site for residue PEG C 501

Chain	Residue
C	GLU311
C	ARG380
C	LYS381

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL E 501

Chain	Residue
A	ARG361
B	U14
E	ARG284
E	TYR411

---

site_id	AC6
Number of Residues	7
Details	binding site for residue PEG E 502

Chain	Residue
A	ARG361
A	ASN362
A	ARG363
E	SER394
E	ARG409
E	TYR411
E	PHE412

---

site_id	AC7
Number of Residues	13
Details	binding site for residue APC F 501

Chain	Residue
F	GLY46
F	ARG50
F	THR130
F	HIS133
F	TYR161
F	GLY162
F	ALA163
F	GLU164
F	SER171
F	GLY172
F	TYR173
F	ARG224
G	G9

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL H 101

Chain	Residue
A	ARG344
B	U13
B	U14
B	A17
H	G2

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14636575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14636575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25640237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UEV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14592988","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R89","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UEV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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