4X49

Crystal structure of the intramolecular trans-sialidase from Ruminococcus gnavus in complex with oseltamivir carboxylate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004308	molecular_function	exo-alpha-sialidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue G39 A 801

Chain	Residue
A	ARG257
A	ARG637
A	TYR677
A	TRP698
A	GOL803
A	HOH1030
A	HOH943
A	ARG276
A	ASP282
A	ASP339
A	ASP356
A	SER364
A	TYR525
A	THR557
A	ARG575

---

site_id	AC2
Number of Residues	7
Details	binding site for residue CA A 802

Chain	Residue
A	ALA517
A	GOL806
A	HOH901
A	HOH1047
A	HOH1071
A	HOH1232
A	HOH1160

---

site_id	AC3
Number of Residues	9
Details	binding site for residue GOL A 803

Chain	Residue
A	ARG257
A	ASP282
A	SER697
A	TRP698
A	ARG700
A	G39801
A	HOH1045
A	HOH1150
A	HOH1008

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 804

Chain	Residue
A	LYS309
A	PHE310
A	ASP311
A	TYR337
A	GLU420
A	TYR459
A	HOH1101
A	HOH1020

---

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL A 805

Chain	Residue
A	HIS540
A	LYS638
A	GLN672
A	GLY674
A	ASP696
A	GLU702
A	HOH945
A	HOH1015

---

site_id	AC6
Number of Residues	11
Details	binding site for residue GOL A 806

Chain	Residue
A	GLU347
A	ALA517
A	GLY518
A	ASP538
A	ASP539
A	HIS540
A	CA802
A	HOH901
A	HOH1044
A	HOH1142
A	HOH1113

---

site_id	AC7
Number of Residues	1
Details	binding site for residue ACE A 807

Chain	Residue
A	THR268

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ACE A 808

Chain	Residue
A	CYS665
A	SER667
A	VAL721
A	PRO723
A	HOH1137
A	HOH1134

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ACE A 809

Chain	Residue
A	GLU687
A	ARG713
A	GLU718
A	HOH940

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