4X46
X-RAY structure thymidine phosphorylase from Salmonella typhimurium complex with SO4 at 2.19 A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
| A | 0006213 | biological_process | pyrimidine nucleoside metabolic process |
| A | 0009032 | molecular_function | thymidine phosphorylase activity |
| A | 0016154 | molecular_function | pyrimidine-nucleoside phosphorylase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0046104 | biological_process | thymidine metabolic process |
| B | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
| B | 0006213 | biological_process | pyrimidine nucleoside metabolic process |
| B | 0009032 | molecular_function | thymidine phosphorylase activity |
| B | 0016154 | molecular_function | pyrimidine-nucleoside phosphorylase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0046104 | biological_process | thymidine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | HIS15 |
| A | ASP138 |
| A | LYS321 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ARG23 |
| A | ASN27 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | ARG115 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | HOH741 |
| A | HOH897 |
| A | ARG271 |
| A | ARG388 |
| A | HOH626 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | ALA175 |
| A | THR176 |
| A | VAL177 |
| A | ASP178 |
| A | HOH629 |
| B | ARG9 |
| B | ARG12 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | HIS15 |
| A | ALA16 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | ASP292 |
| A | ASP293 |
| A | ARG437 |
| A | HOH627 |
| A | HOH808 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 508 |
| Chain | Residue |
| A | GLN5 |
| A | ARG9 |
| A | HOH778 |
| B | HOH622 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 509 |
| Chain | Residue |
| A | LYS84 |
| A | SER86 |
| A | SER95 |
| A | THR123 |
| A | HOH682 |
| A | HOH693 |
| A | HOH723 |
| A | HOH769 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| B | LYS84 |
| B | SER86 |
| B | SER95 |
| B | SER113 |
| B | THR123 |
| B | HOH656 |
| B | HOH688 |
| B | HOH761 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | ARG271 |
| B | ARG388 |
| B | HOH693 |
| B | HOH698 |
| B | HOH833 |
| B | HOH862 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | TYR267 |
| B | PRO270 |
| B | ARG388 |
| B | HOH780 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| A | GLN5 |
| A | ARG9 |
| A | ARG12 |
| B | ALA175 |
| B | THR176 |
| B | VAL177 |
| B | ASP178 |
| B | HOH603 |
| B | HOH617 |
| B | HOH827 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 505 |
| Chain | Residue |
| B | LEU423 |
| B | ASP424 |
| B | ASP425 |
| B | HOH705 |
| B | HOH716 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 506 |
| Chain | Residue |
| B | ASP292 |
| B | ASP293 |
Functional Information from PROSITE/UniProt
| site_id | PS00647 |
| Number of Residues | 16 |
| Details | THYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SGRGLghTGGTlDkLE |
| Chain | Residue | Details |
| A | SER113-GLU128 |
