4X3K

Crystal structure of chromobox homolog 7 (CBX7) chromodomain with H3K27me3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0035102	cellular_component	PRC1 complex
B	0035102	cellular_component	PRC1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue NI A 101

Chain	Residue
A	HIS5
A	GLU8
A	HIS47

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site_id	AC2
Number of Residues	3
Details	binding site for residue NI B 101

Chain	Residue
B	HIS5
B	GLU8
B	HIS47

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site_id	AC3
Number of Residues	4
Details	binding site for residue K B 102

Chain	Residue
B	GLU62
B	LYS19
B	GLU58
B	GLU61

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site_id	AC4
Number of Residues	12
Details	binding site for Di-peptide ARG C 4 and M3L C 5

Chain	Residue
A	HIS5
A	GLU8
A	GLN9
A	PHE11
A	TRP32
A	TRP35
A	GLU43
A	HIS47
A	HOH211
C	ALA3
C	SER6
C	HOH108

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site_id	AC5
Number of Residues	11
Details	binding site for Di-peptide M3L C 5 and SER C 6

Chain	Residue
A	GLN9
A	PHE11
A	TRP32
A	TRP35
A	GLU43
A	HIS47
A	HOH211
C	ARG4
C	ALA7
C	HOH101
C	HOH105

---

site_id	AC6
Number of Residues	13
Details	binding site for Di-peptide ARG D 4 and M3L D 5

Chain	Residue
A	PRO51
B	HIS5
B	GLU8
B	GLN9
B	TRP32
B	TRP35
B	GLU43
B	HIS47
B	HOH265
D	ALA3
D	SER6
D	ALA7
D	HOH102

---

site_id	AC7
Number of Residues	9
Details	binding site for Di-peptide M3L D 5 and SER D 6

Chain	Residue
B	GLN9
B	TRP32
B	TRP35
B	GLU43
B	HIS47
D	ALA3
D	ARG4
D	ALA7
D	HOH102

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Functional Information from PROSITE/UniProt

site_id	PS00598
Number of Residues	21
Details	CHROMO_1 Chromo domain signature. YlVKWkGWppkys.TWEPeehI

Chain	Residue	Details
A	TYR28-ILE48

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708

Chain	Residue	Details
D	LYS1
C	LYS1

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Citrulline => ECO:0000269|PubMed:16567635

Chain	Residue	Details
C	ARG4
D	ARG4

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708

Chain	Residue	Details
C	M3L5
D	M3L5

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588

Chain	Residue	Details
C	SER6
D	SER6

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