4X3K
Crystal structure of chromobox homolog 7 (CBX7) chromodomain with H3K27me3 peptide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue NI A 101 |
| Chain | Residue |
| A | HIS5 |
| A | GLU8 |
| A | HIS47 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue NI B 101 |
| Chain | Residue |
| B | HIS5 |
| B | GLU8 |
| B | HIS47 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue K B 102 |
| Chain | Residue |
| B | GLU62 |
| B | LYS19 |
| B | GLU58 |
| B | GLU61 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide ARG C 4 and M3L C 5 |
| Chain | Residue |
| A | HIS5 |
| A | GLU8 |
| A | GLN9 |
| A | PHE11 |
| A | TRP32 |
| A | TRP35 |
| A | GLU43 |
| A | HIS47 |
| A | HOH211 |
| C | ALA3 |
| C | SER6 |
| C | HOH108 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide M3L C 5 and SER C 6 |
| Chain | Residue |
| A | GLN9 |
| A | PHE11 |
| A | TRP32 |
| A | TRP35 |
| A | GLU43 |
| A | HIS47 |
| A | HOH211 |
| C | ARG4 |
| C | ALA7 |
| C | HOH101 |
| C | HOH105 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ARG D 4 and M3L D 5 |
| Chain | Residue |
| A | PRO51 |
| B | HIS5 |
| B | GLU8 |
| B | GLN9 |
| B | TRP32 |
| B | TRP35 |
| B | GLU43 |
| B | HIS47 |
| B | HOH265 |
| D | ALA3 |
| D | SER6 |
| D | ALA7 |
| D | HOH102 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide M3L D 5 and SER D 6 |
| Chain | Residue |
| B | GLN9 |
| B | TRP32 |
| B | TRP35 |
| B | GLU43 |
| B | HIS47 |
| D | ALA3 |
| D | ARG4 |
| D | ALA7 |
| D | HOH102 |
Functional Information from PROSITE/UniProt
| site_id | PS00598 |
| Number of Residues | 21 |
| Details | CHROMO_1 Chromo domain signature. YlVKWkGWppkys.TWEPeehI |
| Chain | Residue | Details |
| A | TYR28-ILE48 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27595565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29053958","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
