4X3G
Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0007275 | biological_process | multicellular organism development |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| B | 0007275 | biological_process | multicellular organism development |
| B | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | CYS128 |
| A | CYS135 |
| A | HIS147 |
| A | HIS152 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 602 |
| Chain | Residue |
| A | CYS98 |
| A | CYS105 |
| A | HIS117 |
| A | CYS121 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 601 |
| Chain | Residue |
| B | CYS135 |
| B | HIS147 |
| B | HIS152 |
| B | CYS128 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 602 |
| Chain | Residue |
| B | CYS98 |
| B | CYS105 |
| B | HIS117 |
| B | CYS121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | ZN_FING: SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455 |
| Chain | Residue | Details |
| A | SER93-LYS153 | |
| B | SER93-LYS153 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ |
| Chain | Residue | Details |
| A | CYS98 | |
| A | CYS105 | |
| A | HIS117 | |
| A | CYS121 | |
| B | CYS98 | |
| B | CYS105 | |
| B | HIS117 | |
| B | CYS121 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ |
| Chain | Residue | Details |
| A | CYS128 | |
| A | CYS135 | |
| A | HIS147 | |
| A | HIS152 | |
| B | CYS128 | |
| B | CYS135 | |
| B | HIS147 | |
| B | HIS152 |
