4X2V
Crystal structure of the Murine Norovirus NS6 protease (inactive C139A mutant) with a C-terminal extension to include residue P1 prime of NS7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue IMD D 201 |
| Chain | Residue |
| A | GLY124 |
| A | SER125 |
| B | ARG100 |
| C | SER125 |
| D | ARG100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 177 |
| Details | Domain: {"description":"Peptidase C37","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00870","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For 3CLpro activity","evidences":[{"source":"PubMed","id":"26363064","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by 3CLpro","evidences":[{"source":"PubMed","id":"16873239","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26363064","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
