4X2V
Crystal structure of the Murine Norovirus NS6 protease (inactive C139A mutant) with a C-terminal extension to include residue P1 prime of NS7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue IMD D 201 |
| Chain | Residue |
| A | GLY124 |
| A | SER125 |
| B | ARG100 |
| C | SER125 |
| D | ARG100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: For 3CLpro activity => ECO:0000255|PROSITE-ProRule:PRU00870 |
| Chain | Residue | Details |
| A | HIS30 | |
| A | ALA139 | |
| B | HIS30 | |
| B | ALA139 | |
| C | HIS30 | |
| C | ALA139 | |
| D | HIS30 | |
| D | ALA139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: For 3CLpro activity => ECO:0000303|PubMed:26363064 |
| Chain | Residue | Details |
| A | ASP54 | |
| B | ASP54 | |
| C | ASP54 | |
| D | ASP54 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by 3CLpro => ECO:0000269|PubMed:16873239, ECO:0000269|PubMed:26363064 |
| Chain | Residue | Details |
| A | GLN183 | |
| B | GLN183 | |
| C | GLN183 | |
| D | GLN183 |
