4X22

Crystal structure of Leptospira Interrogans Triosephosphate Isomerase (LiTIM)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue EDO A 301

Chain	Residue
A	HOH417

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site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 302

Chain	Residue
A	ASN14
A	ALA74
A	ALA75

---

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO A 303

Chain	Residue
A	SER147
A	ARG150
A	GLU151

---

site_id	AC4
Number of Residues	3
Details	binding site for residue EDO A 304

Chain	Residue
A	HOH427
A	SER183
A	GLU229

---

site_id	AC5
Number of Residues	3
Details	binding site for residue PG0 A 305

Chain	Residue
A	LEU104
A	LEU104
A	PHE110

---

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG

Chain	Residue	Details
A	ALA167-GLY177

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Electrophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---