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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4X0U

Structure ALDH7A1 inactivated by 4-diethylaminobenzaldehyde

Functional Information from GO Data
ChainGOidnamespacecontents
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0004043molecular_functionL-aminoadipate-semialdehyde dehydrogenase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006081biological_processaldehyde metabolic process
A0006554biological_processlysine catabolic process
A0007605biological_processsensory perception of sound
A0008802molecular_functionbetaine-aldehyde dehydrogenase (NAD+) activity
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0019285biological_processglycine betaine biosynthetic process from choline
A0019477biological_processL-lysine catabolic process
A0042426biological_processcholine catabolic process
A0042802molecular_functionidentical protein binding
A0070062cellular_componentextracellular exosome
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0004043molecular_functionL-aminoadipate-semialdehyde dehydrogenase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006081biological_processaldehyde metabolic process
B0006554biological_processlysine catabolic process
B0007605biological_processsensory perception of sound
B0008802molecular_functionbetaine-aldehyde dehydrogenase (NAD+) activity
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0019285biological_processglycine betaine biosynthetic process from choline
B0019477biological_processL-lysine catabolic process
B0042426biological_processcholine catabolic process
B0042802molecular_functionidentical protein binding
B0070062cellular_componentextracellular exosome
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0004043molecular_functionL-aminoadipate-semialdehyde dehydrogenase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006081biological_processaldehyde metabolic process
C0006554biological_processlysine catabolic process
C0007605biological_processsensory perception of sound
C0008802molecular_functionbetaine-aldehyde dehydrogenase (NAD+) activity
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0019285biological_processglycine betaine biosynthetic process from choline
C0019477biological_processL-lysine catabolic process
C0042426biological_processcholine catabolic process
C0042802molecular_functionidentical protein binding
C0070062cellular_componentextracellular exosome
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0004043molecular_functionL-aminoadipate-semialdehyde dehydrogenase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0006081biological_processaldehyde metabolic process
D0006554biological_processlysine catabolic process
D0007605biological_processsensory perception of sound
D0008802molecular_functionbetaine-aldehyde dehydrogenase (NAD+) activity
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0019285biological_processglycine betaine biosynthetic process from choline
D0019477biological_processL-lysine catabolic process
D0042426biological_processcholine catabolic process
D0042802molecular_functionidentical protein binding
D0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues1
Detailsbinding site for residue 3W9 A 601
ChainResidue
APHE168
site_idAC2
Number of Residues2
Detailsbinding site for residue 3W9 B 601
ChainResidue
BPHE168
BPHE468
site_idAC3
Number of Residues3
Detailsbinding site for residue 3W9 C 601
ChainResidue
CASN167
CPHE168
CVAL172
site_idAC4
Number of Residues3
Detailsbinding site for residue 3W9 D 601
ChainResidue
DASN167
DPHE168
DPHE468
site_idAC5
Number of Residues6
Detailsbinding site for residue MG D 602
ChainResidue
CHOH703
CHOH704
DGLU121
DASP124
DHOH710
DHOH839
Functional Information from PROSITE/UniProt
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGNNA
ChainResidueDetails
ALEU267-ALA274
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"26260980","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20207735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26260980","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZVY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20207735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26260980","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2J6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X0T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PDB","id":"4ZUL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DBF1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBF1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBF1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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