4X0L
Human haptoglobin-haemoglobin complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004601 | molecular_function | peroxidase activity |
A | 0005344 | molecular_function | oxygen carrier activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005829 | cellular_component | cytosol |
A | 0005833 | cellular_component | hemoglobin complex |
A | 0015670 | biological_process | carbon dioxide transport |
A | 0015671 | biological_process | oxygen transport |
A | 0016020 | cellular_component | membrane |
A | 0019825 | molecular_function | oxygen binding |
A | 0020037 | molecular_function | heme binding |
A | 0030185 | biological_process | nitric oxide transport |
A | 0031720 | molecular_function | haptoglobin binding |
A | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
A | 0042542 | biological_process | response to hydrogen peroxide |
A | 0042744 | biological_process | hydrogen peroxide catabolic process |
A | 0043177 | molecular_function | organic acid binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0071682 | cellular_component | endocytic vesicle lumen |
A | 0072562 | cellular_component | blood microparticle |
A | 0098869 | biological_process | cellular oxidant detoxification |
B | 0004601 | molecular_function | peroxidase activity |
B | 0005344 | molecular_function | oxygen carrier activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005829 | cellular_component | cytosol |
B | 0005833 | cellular_component | hemoglobin complex |
B | 0008217 | biological_process | regulation of blood pressure |
B | 0015670 | biological_process | carbon dioxide transport |
B | 0015671 | biological_process | oxygen transport |
B | 0019825 | molecular_function | oxygen binding |
B | 0020037 | molecular_function | heme binding |
B | 0030185 | biological_process | nitric oxide transport |
B | 0030492 | molecular_function | hemoglobin binding |
B | 0031720 | molecular_function | haptoglobin binding |
B | 0031721 | molecular_function | hemoglobin alpha binding |
B | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
B | 0042542 | biological_process | response to hydrogen peroxide |
B | 0042744 | biological_process | hydrogen peroxide catabolic process |
B | 0043177 | molecular_function | organic acid binding |
B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0070293 | biological_process | renal absorption |
B | 0070527 | biological_process | platelet aggregation |
B | 0071682 | cellular_component | endocytic vesicle lumen |
B | 0072562 | cellular_component | blood microparticle |
B | 0097746 | biological_process | blood vessel diameter maintenance |
B | 0098869 | biological_process | cellular oxidant detoxification |
B | 1904724 | cellular_component | tertiary granule lumen |
B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
C | 0004252 | molecular_function | serine-type endopeptidase activity |
C | 0006508 | biological_process | proteolysis |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
C | ASN184 | |
B | HIS3 | |
B | LYS83 | |
B | HIS144 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
C | ASN207 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
C | ASN211 | |
A | LEU92 | |
A | LEU107 | |
A | THR109 | |
A | VAL122 | |
A | SER134 | |
A | ALA14 | |
A | TYR25 | |
A | LEU30 | |
A | HIS46 | |
A | ASP48 | |
A | SER53 | |
A | VAL56 | |
A | GLY60 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169 |
Chain | Residue | Details |
C | ASN241 | |
B | GLY75 | |
B | THR85 | |
B | HIS93 | |
B | ARG105 | |
B | LEU111 | |
B | GLY120 | |
B | PHE123 | |
B | ALA129 | |
B | ALA141 | |
B | LYS145 | |
B | GLY26 | |
B | GLY30 | |
B | TYR36 | |
B | TRP38 | |
B | PHE46 | |
B | ASP53 | |
B | GLY57 | |
B | PHE72 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | SITE: Not glycated => ECO:0000269|PubMed:7358733 |
Chain | Residue | Details |
B | LYS60 | |
B | LYS83 | |
B | LYS96 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: N-pyruvate 2-iminyl-valine; in Hb A1b |
Chain | Residue | Details |
B | VAL2 | |
A | LYS17 | |
A | LYS41 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | SER10 | |
B | SER45 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | THR13 | |
B | THR51 | |
B | THR88 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009 |
Chain | Residue | Details |
B | LYS60 | |
B | LYS83 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 |
Chain | Residue | Details |
B | CYS94 | |
A | SER125 | |
A | SER132 | |
A | SER139 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 |
Chain | Residue | Details |
B | LYS145 | |
A | THR135 | |
A | THR138 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 |
Chain | Residue | Details |
B | VAL2 | |
A | LYS17 | |
A | LYS41 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 |
Chain | Residue | Details |
B | LYS9 | |
B | LYS18 | |
B | LYS67 | |
B | LYS121 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 |
Chain | Residue | Details |
B | LYS145 |