4WZ9
APN1 from Anopheles gambiae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016285 | molecular_function | alanyl aminopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043171 | biological_process | peptide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| A | 0098552 | cellular_component | side of membrane |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016285 | molecular_function | alanyl aminopeptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043171 | biological_process | peptide catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0098552 | cellular_component | side of membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | HIS366 |
| A | HIS370 |
| A | GLU389 |
| M | ALA1 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 1002 |
| Chain | Residue |
| A | ASP701 |
| A | THR741 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1003 |
| Chain | Residue |
| A | THR821 |
| A | PHE783 |
| A | GLN784 |
| A | ALA817 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue NHE A 1004 |
| Chain | Residue |
| A | ASP186 |
| A | ARG191 |
| A | GLN271 |
| A | PRO284 |
| A | ASN285 |
| A | PHE287 |
| A | ASN896 |
| A | ALA900 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1001 |
| Chain | Residue |
| B | HIS366 |
| B | HIS370 |
| B | GLU389 |
| N | ALA0 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 1002 |
| Chain | Residue |
| B | THR173 |
| B | ASP175 |
| B | VAL180 |
| B | ASP326 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 1003 |
| Chain | Residue |
| B | GLN784 |
| B | ARG788 |
| B | GLU830 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 1004 |
| Chain | Residue |
| B | GLU669 |
| B | TYR670 |
| B | HIS724 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CU B 1005 |
| Chain | Residue |
| B | GLU86 |
| B | ARG87 |
| B | ARG170 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TIAHEYAHQW |
| Chain | Residue | Details |
| A | THR363-TRP372 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26075520","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WZ9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"26075520","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
