4WYL

Mutant K18E of 3D polymerase from Foot-and-Moth Disease Virus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 501

Chain	Residue
A	PRO209
A	ASN312
A	LEU328
A	TYR331
A	THR332
A	MET333
A	HOH653
A	HOH727

---

site_id	AC2
Number of Residues	1
Details	binding site for residue GOL A 502

Chain	Residue
A	TYR346

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 503

Chain	Residue
A	TRP237
A	ASP238
A	PRO366
A	ALA367
A	ASP368
A	PHE374
A	VAL375

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ACT A 504

Chain	Residue
A	MET111
A	GLU112
A	ARG128
A	ILE189

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MN A 505

Chain	Residue
A	ASP238
A	VAL239
A	ASP240
A	ASP339

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	118
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"25903341","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"For RdRp activity","evidences":[{"source":"UniProtKB","id":"P12296","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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