Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4WXY

PLPS (inactive glutaminase mutant) co-crystallized with glutamine and R5P.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006520	biological_process	amino acid metabolic process
A	0008615	biological_process	pyridoxine biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016843	molecular_function	amine-lyase activity
A	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
A	0042819	biological_process	vitamin B6 biosynthetic process
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
B	0004359	molecular_function	glutaminase activity
B	0005829	cellular_component	cytosol
B	0006541	biological_process	glutamine metabolic process
B	0006543	biological_process	glutamine catabolic process
B	0008614	biological_process	pyridoxine metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
B	0042819	biological_process	vitamin B6 biosynthetic process
B	0042823	biological_process	pyridoxal phosphate biosynthetic process
B	1903600	cellular_component	glutaminase complex
C	0006520	biological_process	amino acid metabolic process
C	0008615	biological_process	pyridoxine biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016843	molecular_function	amine-lyase activity
C	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
C	0042819	biological_process	vitamin B6 biosynthetic process
C	0042823	biological_process	pyridoxal phosphate biosynthetic process
D	0004359	molecular_function	glutaminase activity
D	0005829	cellular_component	cytosol
D	0006541	biological_process	glutamine metabolic process
D	0006543	biological_process	glutamine catabolic process
D	0008614	biological_process	pyridoxine metabolic process
D	0016787	molecular_function	hydrolase activity
D	0016829	molecular_function	lyase activity
D	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
D	0042819	biological_process	vitamin B6 biosynthetic process
D	0042823	biological_process	pyridoxal phosphate biosynthetic process
D	1903600	cellular_component	glutaminase complex
E	0006520	biological_process	amino acid metabolic process
E	0008615	biological_process	pyridoxine biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016843	molecular_function	amine-lyase activity
E	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
E	0042819	biological_process	vitamin B6 biosynthetic process
E	0042823	biological_process	pyridoxal phosphate biosynthetic process
F	0004359	molecular_function	glutaminase activity
F	0005829	cellular_component	cytosol
F	0006541	biological_process	glutamine metabolic process
F	0006543	biological_process	glutamine catabolic process
F	0008614	biological_process	pyridoxine metabolic process
F	0016787	molecular_function	hydrolase activity
F	0016829	molecular_function	lyase activity
F	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
F	0042819	biological_process	vitamin B6 biosynthetic process
F	0042823	biological_process	pyridoxal phosphate biosynthetic process
F	1903600	cellular_component	glutaminase complex
G	0006520	biological_process	amino acid metabolic process
G	0008615	biological_process	pyridoxine biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016843	molecular_function	amine-lyase activity
G	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
G	0042819	biological_process	vitamin B6 biosynthetic process
G	0042823	biological_process	pyridoxal phosphate biosynthetic process
H	0004359	molecular_function	glutaminase activity
H	0005829	cellular_component	cytosol
H	0006541	biological_process	glutamine metabolic process
H	0006543	biological_process	glutamine catabolic process
H	0008614	biological_process	pyridoxine metabolic process
H	0016787	molecular_function	hydrolase activity
H	0016829	molecular_function	lyase activity
H	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
H	0042819	biological_process	vitamin B6 biosynthetic process
H	0042823	biological_process	pyridoxal phosphate biosynthetic process
H	1903600	cellular_component	glutaminase complex
I	0006520	biological_process	amino acid metabolic process
I	0008615	biological_process	pyridoxine biosynthetic process
I	0016829	molecular_function	lyase activity
I	0016843	molecular_function	amine-lyase activity
I	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
I	0042819	biological_process	vitamin B6 biosynthetic process
I	0042823	biological_process	pyridoxal phosphate biosynthetic process
J	0004359	molecular_function	glutaminase activity
J	0005829	cellular_component	cytosol
J	0006541	biological_process	glutamine metabolic process
J	0006543	biological_process	glutamine catabolic process
J	0008614	biological_process	pyridoxine metabolic process
J	0016787	molecular_function	hydrolase activity
J	0016829	molecular_function	lyase activity
J	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
J	0042819	biological_process	vitamin B6 biosynthetic process
J	0042823	biological_process	pyridoxal phosphate biosynthetic process
J	1903600	cellular_component	glutaminase complex
K	0006520	biological_process	amino acid metabolic process
K	0008615	biological_process	pyridoxine biosynthetic process
K	0016829	molecular_function	lyase activity
K	0016843	molecular_function	amine-lyase activity
K	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
K	0042819	biological_process	vitamin B6 biosynthetic process
K	0042823	biological_process	pyridoxal phosphate biosynthetic process
L	0004359	molecular_function	glutaminase activity
L	0005829	cellular_component	cytosol
L	0006541	biological_process	glutamine metabolic process
L	0006543	biological_process	glutamine catabolic process
L	0008614	biological_process	pyridoxine metabolic process
L	0016787	molecular_function	hydrolase activity
L	0016829	molecular_function	lyase activity
L	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
L	0042819	biological_process	vitamin B6 biosynthetic process
L	0042823	biological_process	pyridoxal phosphate biosynthetic process
L	1903600	cellular_component	glutaminase complex

Functional Information from PROSITE/UniProt

site_id	PS01235
Number of Residues	19
Details	PDXS_SNZ_1 PdxS/SNZ family signature. LPVVNFAAGGVTTPADAAL

Chain	Residue	Details
A	LEU205-LEU223

site_id	PS01236
Number of Residues	11
Details	PDXT_SNO_1 PdxT/SNO family family signature. GLVLPGGESTT

Chain	Residue	Details
B	GLY40-THR50

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_01615

Chain	Residue	Details
B	CYG78
D	CYG78
F	CYG78
H	CYG78
J	CYG78
L	CYG78

site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Charge relay system => ECO:0000255\|HAMAP-Rule:MF_01615

Chain	Residue	Details
B	ASN169
J	GLU171
L	ASN169
L	GLU171
B	GLU171
D	ASN169
D	GLU171
F	ASN169
F	GLU171
H	ASN169
H	GLU171
J	ASN169

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01615

Chain	Residue	Details
B	GLY46
H	GLY46
H	ARG105
H	ILE133
J	GLY46
J	ARG105
J	ILE133
L	GLY46
L	ARG105
L	ILE133
I	GLY214
B	ARG105
I	GLY235
K	GLY153
K	ARG165
K	GLY214
K	GLY235
B	ILE133
D	GLY46
D	ARG105
D	ILE133
F	GLY46
F	ARG105
F	ILE133

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)