Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4WXY

PLPS (inactive glutaminase mutant) co-crystallized with glutamine and R5P.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006520	biological_process	amino acid metabolic process
A	0008615	biological_process	pyridoxine biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016843	molecular_function	amine-lyase activity
A	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
A	0042819	biological_process	vitamin B6 biosynthetic process
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
B	0004359	molecular_function	glutaminase activity
B	0005829	cellular_component	cytosol
B	0006543	biological_process	L-glutamine catabolic process
B	0008614	biological_process	pyridoxine metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
B	0042819	biological_process	vitamin B6 biosynthetic process
B	0042823	biological_process	pyridoxal phosphate biosynthetic process
B	1903600	cellular_component	glutaminase complex
C	0006520	biological_process	amino acid metabolic process
C	0008615	biological_process	pyridoxine biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016843	molecular_function	amine-lyase activity
C	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
C	0042819	biological_process	vitamin B6 biosynthetic process
C	0042823	biological_process	pyridoxal phosphate biosynthetic process
D	0004359	molecular_function	glutaminase activity
D	0005829	cellular_component	cytosol
D	0006543	biological_process	L-glutamine catabolic process
D	0008614	biological_process	pyridoxine metabolic process
D	0016787	molecular_function	hydrolase activity
D	0016829	molecular_function	lyase activity
D	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
D	0042819	biological_process	vitamin B6 biosynthetic process
D	0042823	biological_process	pyridoxal phosphate biosynthetic process
D	1903600	cellular_component	glutaminase complex
E	0006520	biological_process	amino acid metabolic process
E	0008615	biological_process	pyridoxine biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016843	molecular_function	amine-lyase activity
E	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
E	0042819	biological_process	vitamin B6 biosynthetic process
E	0042823	biological_process	pyridoxal phosphate biosynthetic process
F	0004359	molecular_function	glutaminase activity
F	0005829	cellular_component	cytosol
F	0006543	biological_process	L-glutamine catabolic process
F	0008614	biological_process	pyridoxine metabolic process
F	0016787	molecular_function	hydrolase activity
F	0016829	molecular_function	lyase activity
F	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
F	0042819	biological_process	vitamin B6 biosynthetic process
F	0042823	biological_process	pyridoxal phosphate biosynthetic process
F	1903600	cellular_component	glutaminase complex
G	0006520	biological_process	amino acid metabolic process
G	0008615	biological_process	pyridoxine biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016843	molecular_function	amine-lyase activity
G	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
G	0042819	biological_process	vitamin B6 biosynthetic process
G	0042823	biological_process	pyridoxal phosphate biosynthetic process
H	0004359	molecular_function	glutaminase activity
H	0005829	cellular_component	cytosol
H	0006543	biological_process	L-glutamine catabolic process
H	0008614	biological_process	pyridoxine metabolic process
H	0016787	molecular_function	hydrolase activity
H	0016829	molecular_function	lyase activity
H	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
H	0042819	biological_process	vitamin B6 biosynthetic process
H	0042823	biological_process	pyridoxal phosphate biosynthetic process
H	1903600	cellular_component	glutaminase complex
I	0006520	biological_process	amino acid metabolic process
I	0008615	biological_process	pyridoxine biosynthetic process
I	0016829	molecular_function	lyase activity
I	0016843	molecular_function	amine-lyase activity
I	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
I	0042819	biological_process	vitamin B6 biosynthetic process
I	0042823	biological_process	pyridoxal phosphate biosynthetic process
J	0004359	molecular_function	glutaminase activity
J	0005829	cellular_component	cytosol
J	0006543	biological_process	L-glutamine catabolic process
J	0008614	biological_process	pyridoxine metabolic process
J	0016787	molecular_function	hydrolase activity
J	0016829	molecular_function	lyase activity
J	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
J	0042819	biological_process	vitamin B6 biosynthetic process
J	0042823	biological_process	pyridoxal phosphate biosynthetic process
J	1903600	cellular_component	glutaminase complex
K	0006520	biological_process	amino acid metabolic process
K	0008615	biological_process	pyridoxine biosynthetic process
K	0016829	molecular_function	lyase activity
K	0016843	molecular_function	amine-lyase activity
K	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
K	0042819	biological_process	vitamin B6 biosynthetic process
K	0042823	biological_process	pyridoxal phosphate biosynthetic process
L	0004359	molecular_function	glutaminase activity
L	0005829	cellular_component	cytosol
L	0006543	biological_process	L-glutamine catabolic process
L	0008614	biological_process	pyridoxine metabolic process
L	0016787	molecular_function	hydrolase activity
L	0016829	molecular_function	lyase activity
L	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
L	0042819	biological_process	vitamin B6 biosynthetic process
L	0042823	biological_process	pyridoxal phosphate biosynthetic process
L	1903600	cellular_component	glutaminase complex

Functional Information from PROSITE/UniProt

site_id	PS01235
Number of Residues	19
Details	PDXS_SNZ_1 PdxS/SNZ family signature. LPVVNFAAGGVTTPADAAL

Chain	Residue	Details
A	LEU205-LEU223

site_id	PS01236
Number of Residues	11
Details	PDXT_SNO_1 PdxT/SNO family family signature. GLVLPGGESTT

Chain	Residue	Details
B	GLY40-THR50

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Schiff-base intermediate with D-ribose 5-phosphate","evidences":[{"source":"HAMAP-Rule","id":"MF_01824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15911615","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15911615","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01824","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01615","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_01615","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01615","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)