Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003682 | molecular_function | chromatin binding |
A | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
A | 0005634 | cellular_component | nucleus |
A | 0006346 | biological_process | DNA methylation-dependent heterochromatin formation |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008270 | molecular_function | zinc ion binding |
B | 0003677 | molecular_function | DNA binding |
B | 0003682 | molecular_function | chromatin binding |
B | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
B | 0005634 | cellular_component | nucleus |
B | 0006346 | biological_process | DNA methylation-dependent heterochromatin formation |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1701 |
Chain | Residue |
A | CYS1476 |
A | CYS1478 |
A | CYS1485 |
A | HIS1502 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1702 |
Chain | Residue |
A | HIS793 |
A | CYS820 |
A | CYS893 |
A | CYS896 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue ZN A 1703 |
Chain | Residue |
A | GLY665 |
A | CYS667 |
A | CYS670 |
A | CYS686 |
A | CYS664 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue ZN A 1704 |
Chain | Residue |
A | CYS653 |
A | GLY654 |
A | CYS656 |
A | CYS659 |
A | CYS691 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1705 |
Chain | Residue |
A | CYS353 |
A | CYS356 |
A | CYS414 |
A | HIS418 |
site_id | AC6 |
Number of Residues | 19 |
Details | binding site for residue SAH A 1706 |
Chain | Residue |
A | PHE1145 |
A | SER1146 |
A | GLY1147 |
A | CYS1148 |
A | GLY1150 |
A | LEU1151 |
A | GLU1168 |
A | MET1169 |
A | TRP1170 |
A | GLU1189 |
A | ASP1190 |
A | CYS1191 |
A | GLY1223 |
A | LEU1247 |
A | ASN1578 |
A | ALA1579 |
A | VAL1580 |
A | HOH1918 |
A | HOH2051 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1701 |
Chain | Residue |
B | CYS1476 |
B | CYS1478 |
B | CYS1485 |
B | HIS1502 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1702 |
Chain | Residue |
B | HIS793 |
B | CYS820 |
B | CYS893 |
B | CYS896 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue ZN B 1703 |
Chain | Residue |
B | CYS664 |
B | GLY665 |
B | CYS667 |
B | CYS670 |
B | CYS686 |
B | GLN687 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue ZN B 1704 |
Chain | Residue |
B | CYS653 |
B | GLY654 |
B | CYS656 |
B | CYS659 |
B | CYS691 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue ZN B 1705 |
Chain | Residue |
B | CYS353 |
B | CYS356 |
B | CYS414 |
B | HIS418 |
site_id | AD3 |
Number of Residues | 17 |
Details | binding site for residue SAH B 1706 |
Chain | Residue |
B | PHE1145 |
B | SER1146 |
B | GLY1147 |
B | GLY1150 |
B | LEU1151 |
B | GLU1168 |
B | MET1169 |
B | TRP1170 |
B | GLU1189 |
B | ASP1190 |
B | CYS1191 |
B | GLY1223 |
B | LEU1247 |
B | ASN1578 |
B | ALA1579 |
B | VAL1580 |
B | HOH1974 |
Functional Information from PROSITE/UniProt
site_id | PS00094 |
Number of Residues | 13 |
Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS |
Chain | Residue | Details |
A | GLU1218-SER1230 | |
site_id | PS00095 |
Number of Residues | 19 |
Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI |
Chain | Residue | Details |
A | ARG1574-ILE1592 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLY982-HIS1028 | |
B | GLY982-HIS1028 | |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | THR1562 | |
B | THR1562 | |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG689 | |
A | PRO692 | |
A | VAL750 | |
A | ALA754 | |
B | ARG689 | |
B | PRO692 | |
B | VAL750 | |
B | ALA754 | |
Chain | Residue | Details |
A | GLU989 | |
B | ARG992 | |
B | ARG995 | |
B | PHE1000 | |
B | LYS1003 | |
B | ASN1006 | |
B | TYR1022 | |
B | THR1027 | |
A | ARG992 | |
A | ARG995 | |
A | PHE1000 | |
A | LYS1003 | |
A | ASN1006 | |
A | TYR1022 | |
A | THR1027 | |
B | GLU989 | |
Chain | Residue | Details |
A | GLY1482 | |
A | ASP1486 | |
A | THR1526 | |
B | GLY1482 | |
B | ASP1486 | |
B | THR1526 | |
Chain | Residue | Details |
A | GLY1504 | |
A | VAL1527 | |
B | GLY1504 | |
B | VAL1527 | |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | SITE: Important for activity => ECO:0000250 |
Chain | Residue | Details |
A | MET845 | |
B | MET845 | |
Chain | Residue | Details |
A | LYS406 | |
B | LYS406 | |
Chain | Residue | Details |
A | GLU463 | |
B | GLU463 | |
Chain | Residue | Details |
A | PHE469 | |
B | PHE469 | |
Chain | Residue | Details |
A | GLU473 | |
A | MET502 | |
B | GLU473 | |
B | MET502 | |
Chain | Residue | Details |
A | ILE477 | |
A | MET845 | |
B | ILE477 | |
B | MET845 | |
Chain | Residue | Details |
A | GLY478 | |
B | GLY478 | |
Chain | Residue | Details |
A | PHE479 | |
B | PHE479 | |
Chain | Residue | Details |
A | LEU488 | |
B | LEU488 | |
Chain | Residue | Details |
A | ASP490 | |
B | ASP490 | |
Chain | Residue | Details |
A | ALA496 | |
B | ALA496 | |
B | TYR524 | |
B | ASP702 | |
B | PHE1085 | |
B | GLN1227 | |
B | GLN1293 | |
B | GLY1297 | |
B | ARG1311 | |
B | GLY1390 | |
A | TYR524 | |
A | ASP702 | |
A | PHE1085 | |
A | GLN1227 | |
A | GLN1293 | |
A | GLY1297 | |
A | ARG1311 | |
A | GLY1390 | |
Chain | Residue | Details |
A | SER509 | |
B | SER509 | |
Chain | Residue | Details |
A | ARG595 | |
B | ARG595 | |
Chain | Residue | Details |
A | PHE648 | |
A | VAL734 | |
A | THR885 | |
A | LYS1214 | |
B | PHE648 | |
B | VAL734 | |
B | THR885 | |
B | LYS1214 | |
Chain | Residue | Details |
A | ARG730 | |
B | ARG730 | |
Chain | Residue | Details |
A | VAL1050 | |
B | VAL1050 | |
Chain | Residue | Details |
A | LEU1068 | |
B | LEU1068 | |
Chain | Residue | Details |
A | SER1447 | |
A | GLY1449 | |
A | MET1451 | |
B | SER1447 | |
B | GLY1449 | |
B | MET1451 | |
Chain | Residue | Details |
A | ARG1453 | |
B | ARG1453 | |
Chain | Residue | Details |
A | LEU1455 | |
A | TYR1457 | |
B | LEU1455 | |
B | TYR1457 | |
site_id | SWS_FT_FI27 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | ARG595 | |
B | ARG595 | |