4WXX
The crystal structure of human DNMT1(351-1600)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003682 | molecular_function | chromatin binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1701 |
| Chain | Residue |
| A | CYS1476 |
| A | CYS1478 |
| A | CYS1485 |
| A | HIS1502 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1702 |
| Chain | Residue |
| A | HIS793 |
| A | CYS820 |
| A | CYS893 |
| A | CYS896 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1703 |
| Chain | Residue |
| A | GLY665 |
| A | CYS667 |
| A | CYS670 |
| A | CYS686 |
| A | CYS664 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1704 |
| Chain | Residue |
| A | CYS653 |
| A | GLY654 |
| A | CYS656 |
| A | CYS659 |
| A | CYS691 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1705 |
| Chain | Residue |
| A | CYS353 |
| A | CYS356 |
| A | CYS414 |
| A | HIS418 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | binding site for residue SAH A 1706 |
| Chain | Residue |
| A | PHE1145 |
| A | SER1146 |
| A | GLY1147 |
| A | CYS1148 |
| A | GLY1150 |
| A | LEU1151 |
| A | GLU1168 |
| A | MET1169 |
| A | TRP1170 |
| A | GLU1189 |
| A | ASP1190 |
| A | CYS1191 |
| A | GLY1223 |
| A | LEU1247 |
| A | ASN1578 |
| A | ALA1579 |
| A | VAL1580 |
| A | HOH1918 |
| A | HOH2051 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1701 |
| Chain | Residue |
| B | CYS1476 |
| B | CYS1478 |
| B | CYS1485 |
| B | HIS1502 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1702 |
| Chain | Residue |
| B | HIS793 |
| B | CYS820 |
| B | CYS893 |
| B | CYS896 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 1703 |
| Chain | Residue |
| B | CYS664 |
| B | GLY665 |
| B | CYS667 |
| B | CYS670 |
| B | CYS686 |
| B | GLN687 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 1704 |
| Chain | Residue |
| B | CYS653 |
| B | GLY654 |
| B | CYS656 |
| B | CYS659 |
| B | CYS691 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1705 |
| Chain | Residue |
| B | CYS353 |
| B | CYS356 |
| B | CYS414 |
| B | HIS418 |
| site_id | AD3 |
| Number of Residues | 17 |
| Details | binding site for residue SAH B 1706 |
| Chain | Residue |
| B | PHE1145 |
| B | SER1146 |
| B | GLY1147 |
| B | GLY1150 |
| B | LEU1151 |
| B | GLU1168 |
| B | MET1169 |
| B | TRP1170 |
| B | GLU1189 |
| B | ASP1190 |
| B | CYS1191 |
| B | GLY1223 |
| B | LEU1247 |
| B | ASN1578 |
| B | ALA1579 |
| B | VAL1580 |
| B | HOH1974 |
Functional Information from PROSITE/UniProt
| site_id | PS00094 |
| Number of Residues | 13 |
| Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS |
| Chain | Residue | Details |
| A | GLU1218-SER1230 |
| site_id | PS00095 |
| Number of Residues | 19 |
| Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI |
| Chain | Residue | Details |
| A | ARG1574-ILE1592 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 250 |
| Details | Domain: {"description":"BAH 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00370","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 920 |
| Details | Domain: {"description":"SAM-dependent MTase C5-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 92 |
| Details | Region: {"description":"Required for activity"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 60 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00509","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13864","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21163962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PTA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for activity","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 16 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21947282","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P13864","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 61 |
| Details | Region: {"description":"Autoinhibitory linker"} |
| Chain | Residue | Details |
