4WSH

Crystal structure of Probable Uroporphyrinogen decarboxylase (UPD) (URO-D) from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004853	molecular_function	uroporphyrinogen decarboxylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006778	biological_process	porphyrin-containing compound metabolic process
A	0006779	biological_process	porphyrin-containing compound biosynthetic process
A	0006782	biological_process	protoporphyrinogen IX biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019353	biological_process	protoporphyrinogen IX biosynthetic process from glutamate
B	0004853	molecular_function	uroporphyrinogen decarboxylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006778	biological_process	porphyrin-containing compound metabolic process
B	0006779	biological_process	porphyrin-containing compound biosynthetic process
B	0006782	biological_process	protoporphyrinogen IX biosynthetic process
B	0006783	biological_process	heme biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019353	biological_process	protoporphyrinogen IX biosynthetic process from glutamate

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 400

Chain	Residue
A	ILE276
A	ASN292
A	ARG311
A	HOH662

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 401

Chain	Residue
A	GLY355
A	HOH637
A	PRO17
A	VAL18
A	GLY319
A	THR320
A	HIS354

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 402

Chain	Residue
A	ARG27
A	GLY30
A	ARG31
A	PRO332
A	HOH606
A	HOH663

---

site_id	AC4
Number of Residues	2
Details	binding site for residue SO4 A 403

Chain	Residue
A	ARG237
A	GLU238

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 404

Chain	Residue
A	SER106
A	LEU107
A	ASN175
A	HOH667

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 405

Chain	Residue
A	GLN16
A	ARG243
A	HOH703

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 406

Chain	Residue
A	ARG8
A	HOH621
B	ARG11

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 A 407

Chain	Residue
A	ARG27
A	HIS328
A	GLY329

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CL B 400

Chain	Residue
B	ILE276
B	ASN292
B	ARG311
B	HOH532

---

site_id	AD1
Number of Residues	8
Details	binding site for residue SO4 B 401

Chain	Residue
B	PRO17
B	VAL18
B	GLY319
B	THR320
B	HIS354
B	GLY355
B	HOH604
B	HOH631

---

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 B 402

Chain	Residue
B	ARG27
B	GLY30
B	ARG31
B	PRO332
B	HOH558
B	HOH606
B	HOH632
B	HOH664

---

Functional Information from PROSITE/UniProt

site_id	PS00906
Number of Residues	10
Details	UROD_1 Uroporphyrinogen decarboxylase signature 1. PVWMMRQAGR

Chain	Residue	Details
A	PRO22-ARG31

---

site_id	PS00907
Number of Residues	17
Details	UROD_2 Uroporphyrinogen decarboxylase signature 2. IGFSGsPWTLatYmv.EG

Chain	Residue	Details
A	ILE143-GLY159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00218","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_00218","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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