Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4WQT

Thermus thermophilus RNA polymerase complexed with an RNA cleavage stimulating factor (a GreA/Gfh1 chimeric protein)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0046983	molecular_function	protein dimerization activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046983	molecular_function	protein dimerization activity
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000287	molecular_function	magnesium ion binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
D	0005515	molecular_function	protein binding
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0046872	molecular_function	metal ion binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034062	molecular_function	5'-3' RNA polymerase activity
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006351	biological_process	DNA-templated transcription
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0034062	molecular_function	5'-3' RNA polymerase activity
F	0046983	molecular_function	protein dimerization activity
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0003677	molecular_function	DNA binding
G	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006351	biological_process	DNA-templated transcription
G	0016740	molecular_function	transferase activity
G	0016779	molecular_function	nucleotidyltransferase activity
G	0034062	molecular_function	5'-3' RNA polymerase activity
G	0046983	molecular_function	protein dimerization activity
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003677	molecular_function	DNA binding
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0006351	biological_process	DNA-templated transcription
H	0016740	molecular_function	transferase activity
H	0016779	molecular_function	nucleotidyltransferase activity
H	0032549	molecular_function	ribonucleoside binding
H	0034062	molecular_function	5'-3' RNA polymerase activity
I	0000287	molecular_function	magnesium ion binding
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0003677	molecular_function	DNA binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005515	molecular_function	protein binding
I	0006351	biological_process	DNA-templated transcription
I	0008270	molecular_function	zinc ion binding
I	0016740	molecular_function	transferase activity
I	0016779	molecular_function	nucleotidyltransferase activity
I	0034062	molecular_function	5'-3' RNA polymerase activity
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0006351	biological_process	DNA-templated transcription
J	0016740	molecular_function	transferase activity
J	0016779	molecular_function	nucleotidyltransferase activity
J	0034062	molecular_function	5'-3' RNA polymerase activity
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0006351	biological_process	DNA-templated transcription
K	0016740	molecular_function	transferase activity
K	0016779	molecular_function	nucleotidyltransferase activity
K	0034062	molecular_function	5'-3' RNA polymerase activity
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0006351	biological_process	DNA-templated transcription
L	0016740	molecular_function	transferase activity
L	0016779	molecular_function	nucleotidyltransferase activity
L	0034062	molecular_function	5'-3' RNA polymerase activity
L	0046983	molecular_function	protein dimerization activity
M	0000428	cellular_component	DNA-directed RNA polymerase complex
M	0003677	molecular_function	DNA binding
M	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
M	0006351	biological_process	DNA-templated transcription
M	0016740	molecular_function	transferase activity
M	0016779	molecular_function	nucleotidyltransferase activity
M	0032549	molecular_function	ribonucleoside binding
M	0034062	molecular_function	5'-3' RNA polymerase activity
N	0000287	molecular_function	magnesium ion binding
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0003677	molecular_function	DNA binding
N	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
N	0005515	molecular_function	protein binding
N	0006351	biological_process	DNA-templated transcription
N	0008270	molecular_function	zinc ion binding
N	0016740	molecular_function	transferase activity
N	0016779	molecular_function	nucleotidyltransferase activity
N	0034062	molecular_function	5'-3' RNA polymerase activity
N	0046872	molecular_function	metal ion binding
O	0000428	cellular_component	DNA-directed RNA polymerase complex
O	0003677	molecular_function	DNA binding
O	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
O	0006351	biological_process	DNA-templated transcription
O	0016740	molecular_function	transferase activity
O	0016779	molecular_function	nucleotidyltransferase activity
O	0034062	molecular_function	5'-3' RNA polymerase activity
X	0003677	molecular_function	DNA binding
X	0032784	biological_process	regulation of DNA-templated transcription elongation
X	0070063	molecular_function	RNA polymerase binding
Y	0003677	molecular_function	DNA binding
Y	0032784	biological_process	regulation of DNA-templated transcription elongation
Y	0070063	molecular_function	RNA polymerase binding
Z	0003677	molecular_function	DNA binding
Z	0032784	biological_process	regulation of DNA-templated transcription elongation
Z	0070063	molecular_function	RNA polymerase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN D 2001

Chain	Residue
D	CYS1112
D	CYS1194
D	VAL1200
D	CYS1201
D	CYS1204

site_id	AC2
Number of Residues	3
Details	binding site for residue MG D 2002

Chain	Residue
D	ASP739
D	ASP741
D	ASP743

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN I 1601

Chain	Residue
I	CYS1194
I	VAL1200
I	CYS1201
I	CYS1204
I	CYS1112

site_id	AC4
Number of Residues	3
Details	binding site for residue MG I 1602

Chain	Residue
I	ASP739
I	ASP741
I	ASP743

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN N 1601

Chain	Residue
N	CYS1112
N	CYS1194
N	CYS1201
N	CYS1204

site_id	AC6
Number of Residues	3
Details	binding site for residue MG N 1602

Chain	Residue
N	ASP739
N	ASP741
N	ASP743

Functional Information from PROSITE/UniProt

site_id	PS00830
Number of Residues	17
Details	GREAB_2 Prokaryotic transcription elongation factors signature 2. SdaSPMGkALLghrvGD

Chain	Residue	Details
X	SER120-ASP136

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV

Chain	Residue	Details
C	GLY836-VAL848

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:16298991

Chain	Residue	Details
X	GLU20
D	CYS1201
D	CYS1204
I	CYS58
I	CYS60
I	CYS73
I	CYS76
I	ASP739
I	ASP741
I	ASP743
I	CYS1112
X	GLU24
I	CYS1194
I	CYS1201
I	CYS1204
N	CYS58
N	CYS60
N	CYS73
N	CYS76
N	ASP739
N	ASP741
N	ASP743
Y	GLU20
N	CYS1112
N	CYS1194
N	CYS1201
N	CYS1204
Y	GLU24
Z	GLU20
Z	GLU24
D	ASP743
D	CYS1112
D	CYS1194

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)