4WPG

Group A Streptococcus GacA is an essential dTDP-4-dehydrorhamnose reductase (RmlD)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006556	biological_process	S-adenosylmethionine biosynthetic process
A	0008831	molecular_function	dTDP-4-dehydrorhamnose reductase activity
A	0016491	molecular_function	oxidoreductase activity
A	0019305	biological_process	dTDP-rhamnose biosynthetic process
A	0045226	biological_process	extracellular polysaccharide biosynthetic process
A	0048269	cellular_component	methionine adenosyltransferase complex
A	0048270	molecular_function	methionine adenosyltransferase regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue MPD A 301

Chain	Residue
A	GLU0
A	LEU19
A	ARG22
A	TYR55
A	ARG174
A	CYS196
A	THR199
A	GLU200

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site_id	AC2
Number of Residues	7
Details	binding site for residue MRD A 302

Chain	Residue
A	THR52
A	THR95
A	THR199
A	HOH432
A	HOH507
A	HOH571
A	GLU0

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site_id	AC3
Number of Residues	3
Details	binding site for residue PO4 A 303

Chain	Residue
A	TRP220
A	HOH527
A	HOH834

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