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4WP0

Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0008483molecular_functiontransaminase activity
A0009058biological_processbiosynthetic process
A0009617biological_processresponse to bacterium
A0016212molecular_functionkynurenine-oxoglutarate transaminase activity
A0016829molecular_functionlyase activity
A0030170molecular_functionpyridoxal phosphate binding
A0042803molecular_functionprotein homodimerization activity
A0047316molecular_functionglutamine-phenylpyruvate transaminase activity
A0047804molecular_functioncysteine-S-conjugate beta-lyase activity
A0070189biological_processkynurenine metabolic process
A0097053biological_processL-kynurenine catabolic process
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0008483molecular_functiontransaminase activity
B0009058biological_processbiosynthetic process
B0009617biological_processresponse to bacterium
B0016212molecular_functionkynurenine-oxoglutarate transaminase activity
B0016829molecular_functionlyase activity
B0030170molecular_functionpyridoxal phosphate binding
B0042803molecular_functionprotein homodimerization activity
B0047316molecular_functionglutamine-phenylpyruvate transaminase activity
B0047804molecular_functioncysteine-S-conjugate beta-lyase activity
B0070189biological_processkynurenine metabolic process
B0097053biological_processL-kynurenine catabolic process
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0008483molecular_functiontransaminase activity
C0009058biological_processbiosynthetic process
C0009617biological_processresponse to bacterium
C0016212molecular_functionkynurenine-oxoglutarate transaminase activity
C0016829molecular_functionlyase activity
C0030170molecular_functionpyridoxal phosphate binding
C0042803molecular_functionprotein homodimerization activity
C0047316molecular_functionglutamine-phenylpyruvate transaminase activity
C0047804molecular_functioncysteine-S-conjugate beta-lyase activity
C0070189biological_processkynurenine metabolic process
C0097053biological_processL-kynurenine catabolic process
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0008483molecular_functiontransaminase activity
D0009058biological_processbiosynthetic process
D0009617biological_processresponse to bacterium
D0016212molecular_functionkynurenine-oxoglutarate transaminase activity
D0016829molecular_functionlyase activity
D0030170molecular_functionpyridoxal phosphate binding
D0042803molecular_functionprotein homodimerization activity
D0047316molecular_functionglutamine-phenylpyruvate transaminase activity
D0047804molecular_functioncysteine-S-conjugate beta-lyase activity
D0070189biological_processkynurenine metabolic process
D0097053biological_processL-kynurenine catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:15364907, ECO:0007744|PDB:1W7M
ChainResidueDetails
AGLY36
DGLY36
DASN185
DARG398
AASN185
AARG398
BGLY36
BASN185
BARG398
CGLY36
CASN185
CARG398

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:15364907, ECO:0007744|PDB:1W7L, ECO:0007744|PDB:1W7M
ChainResidueDetails
ALLP247
BLLP247
CLLP247
DLLP247

226707

PDB entries from 2024-10-30

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