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4WM6

High pressure protein crystallography of hen egg white lysozyme at 950 MPa

Functional Information from GO Data
ChainGOidnamespacecontents
A0003796molecular_functionlysozyme activity
A0003824molecular_functioncatalytic activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0008152biological_processmetabolic process
A0016231molecular_functionbeta-N-acetylglucosaminidase activity
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0016998biological_processcell wall macromolecule catabolic process
A0031640biological_processkilling of cells of another organism
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0051672biological_processobsolete catabolism by organism of cell wall peptidoglycan in other organism
B0003796molecular_functionlysozyme activity
B0003824molecular_functioncatalytic activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0008152biological_processmetabolic process
B0016231molecular_functionbeta-N-acetylglucosaminidase activity
B0016787molecular_functionhydrolase activity
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0016998biological_processcell wall macromolecule catabolic process
B0031640biological_processkilling of cells of another organism
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0050829biological_processdefense response to Gram-negative bacterium
B0050830biological_processdefense response to Gram-positive bacterium
B0051672biological_processobsolete catabolism by organism of cell wall peptidoglycan in other organism
C0003796molecular_functionlysozyme activity
C0003824molecular_functioncatalytic activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0008152biological_processmetabolic process
C0016231molecular_functionbeta-N-acetylglucosaminidase activity
C0016787molecular_functionhydrolase activity
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0016998biological_processcell wall macromolecule catabolic process
C0031640biological_processkilling of cells of another organism
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0050829biological_processdefense response to Gram-negative bacterium
C0050830biological_processdefense response to Gram-positive bacterium
C0051672biological_processobsolete catabolism by organism of cell wall peptidoglycan in other organism
D0003796molecular_functionlysozyme activity
D0003824molecular_functioncatalytic activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0008152biological_processmetabolic process
D0016231molecular_functionbeta-N-acetylglucosaminidase activity
D0016787molecular_functionhydrolase activity
D0016798molecular_functionhydrolase activity, acting on glycosyl bonds
D0016998biological_processcell wall macromolecule catabolic process
D0031640biological_processkilling of cells of another organism
D0042742biological_processdefense response to bacterium
D0042802molecular_functionidentical protein binding
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0051672biological_processobsolete catabolism by organism of cell wall peptidoglycan in other organism
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue NA A 201
ChainResidue
ASER60
ACYS64
ASER72
AARG73
AHOH356

site_idAC2
Number of Residues7
Detailsbinding site for residue NA B 201
ChainResidue
BSER72
BARG73
BASN74
BSER60
BARG61
BTRP63
BCYS64

site_idAC3
Number of Residues6
Detailsbinding site for residue NA C 201
ChainResidue
CSER60
CCYS64
CASN65
CSER72
CARG73
CHOH333

site_idAC4
Number of Residues9
Detailsbinding site for residue NA D 201
ChainResidue
DSER60
DARG61
DTRP62
DTRP63
DCYS64
DSER72
DARG73
DASN74
DHOH410

Functional Information from PROSITE/UniProt
site_idPS00128
Number of Residues19
DetailsGLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC
ChainResidueDetails
ACYS76-CYS94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE:
ChainResidueDetails
AGLU35
AASP52
BGLU35
BASP52
CGLU35
CASP52
DGLU35
DASP52

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AASP101
BASP101
CASP101
DASP101

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 203
ChainResidueDetails
AGLU35hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
AASN46
AASP48
ASER50
AASP52covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
AASN59

site_idMCSA2
Number of Residues6
DetailsM-CSA 203
ChainResidueDetails
BGLU35hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
BASN46
BASP48
BSER50
BASP52covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
BASN59

site_idMCSA3
Number of Residues6
DetailsM-CSA 203
ChainResidueDetails
CGLU35hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
CASN46
CASP48
CSER50
CASP52covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
CASN59

site_idMCSA4
Number of Residues6
DetailsM-CSA 203
ChainResidueDetails
DGLU35hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
DASN46
DASP48
DSER50
DASP52covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
DASN59

218500

PDB entries from 2024-04-17

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