4WLJ

High resolution crystal structure of human kynurenine aminotransferase-I in complex with aminooxyacetate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008483	molecular_function	transaminase activity
A	0009058	biological_process	biosynthetic process
A	0009617	biological_process	response to bacterium
A	0016212	molecular_function	kynurenine-oxoglutarate transaminase activity
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0042803	molecular_function	protein homodimerization activity
A	0047316	molecular_function	glutamine-phenylpyruvate transaminase activity
A	0047804	molecular_function	cysteine-S-conjugate beta-lyase activity
A	0070189	biological_process	kynurenine metabolic process
A	0097053	biological_process	L-kynurenine catabolic process
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0008483	molecular_function	transaminase activity
B	0009058	biological_process	biosynthetic process
B	0009617	biological_process	response to bacterium
B	0016212	molecular_function	kynurenine-oxoglutarate transaminase activity
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0030170	molecular_function	pyridoxal phosphate binding
B	0042803	molecular_function	protein homodimerization activity
B	0047316	molecular_function	glutamine-phenylpyruvate transaminase activity
B	0047804	molecular_function	cysteine-S-conjugate beta-lyase activity
B	0070189	biological_process	kynurenine metabolic process
B	0097053	biological_process	L-kynurenine catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue IK2 A 501

Chain	Residue
A	GLY36
A	TYR216
A	SER244
A	LYS247
A	LYS255
A	ARG398
A	HOH646
B	TYR63
A	GLY99
A	GLY100
A	TYR101
A	PHE125
A	ASN181
A	ASN185
A	ASP213
A	VAL215

---

site_id	AC2
Number of Residues	16
Details	binding site for residue IK2 B 501

Chain	Residue
A	TYR63
B	GLY36
B	GLY99
B	GLY100
B	TYR101
B	PHE125
B	ASN181
B	ASN185
B	ASP213
B	VAL215
B	TYR216
B	SER244
B	LYS247
B	LYS255
B	ARG398
B	HOH683

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15364907","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W7M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"15364907","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W7L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1W7M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---