4WKP

Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 2-(2-hydroxyethoxy)ethylthiomethyl-DADMe-Immucillin-A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
A	0008930	molecular_function	methylthioadenosine nucleosidase activity
A	0009086	biological_process	methionine biosynthetic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009234	biological_process	menaquinone biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
A	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
B	0008930	molecular_function	methylthioadenosine nucleosidase activity
B	0009086	biological_process	methionine biosynthetic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009234	biological_process	menaquinone biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
C	0008930	molecular_function	methylthioadenosine nucleosidase activity
C	0009086	biological_process	methionine biosynthetic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009234	biological_process	menaquinone biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
D	0008930	molecular_function	methylthioadenosine nucleosidase activity
D	0009086	biological_process	methionine biosynthetic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009234	biological_process	menaquinone biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue 3QA A 301

Chain	Residue
A	ALA9
A	GLU173
A	MET174
A	GLU175
A	SER197
A	ASP198
A	ALA200
A	PHE208
A	HOH436
A	HOH483
B	HIS109
A	ILE52
B	PRO115
A	VAL78
A	ALA79
A	GLY80
A	GLN152
A	PHE153
A	VAL154
A	VAL172

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 302

Chain	Residue
A	GLU210
A	HOH406
A	HOH412
A	HOH421
D	SER124
D	GLY125
D	SER126

---

site_id	AC3
Number of Residues	24
Details	binding site for residue 3QA B 301

Chain	Residue
A	PHE107
A	HIS109
A	PRO115
B	ALA9
B	MET10
B	ILE52
B	VAL78
B	ALA79
B	GLY80
B	GLN152
B	PHE153
B	VAL154
B	VAL172
B	GLU173
B	MET174
B	GLU175
B	SER197
B	ASP198
B	ALA200
B	PHE208
B	HOH403
B	HOH425
B	HOH451
C	ASN136

---

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 B 302

Chain	Residue
B	GLU210
B	HOH419
B	HOH422
C	SER124
C	GLY125
C	SER126
C	PRO189

---

site_id	AC5
Number of Residues	19
Details	binding site for residue 3QA C 301

Chain	Residue
C	ALA9
C	GLU12
C	ILE52
C	VAL78
C	ALA79
C	GLY80
C	PHE153
C	VAL154
C	VAL172
C	GLU173
C	MET174
C	GLU175
C	SER197
C	ASP198
C	ALA200
C	PHE208
C	HOH463
C	HOH524
D	PHE107

---

site_id	AC6
Number of Residues	19
Details	binding site for residue 3QA D 301

Chain	Residue
C	PHE107
D	ALA9
D	GLU12
D	ILE52
D	VAL78
D	ALA79
D	GLY80
D	PHE153
D	VAL154
D	VAL172
D	GLU173
D	MET174
D	GLU175
D	SER197
D	ASP198
D	ALA200
D	PHE208
D	HOH443
D	HOH547

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20954236","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"20954236","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---