4WKP
Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 2-(2-hydroxyethoxy)ethylthiomethyl-DADMe-Immucillin-A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| A | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009234 | biological_process | menaquinone biosynthetic process |
| A | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| A | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| B | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009234 | biological_process | menaquinone biosynthetic process |
| B | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| B | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| C | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009234 | biological_process | menaquinone biosynthetic process |
| C | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| C | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| C | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| D | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009234 | biological_process | menaquinone biosynthetic process |
| D | 0019284 | biological_process | L-methionine salvage from S-adenosylmethionine |
| D | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| D | 0102246 | molecular_function | 6-amino-6-deoxyfutalosine hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue 3QA A 301 |
| Chain | Residue |
| A | ALA9 |
| A | GLU173 |
| A | MET174 |
| A | GLU175 |
| A | SER197 |
| A | ASP198 |
| A | ALA200 |
| A | PHE208 |
| A | HOH436 |
| A | HOH483 |
| B | HIS109 |
| A | ILE52 |
| B | PRO115 |
| A | VAL78 |
| A | ALA79 |
| A | GLY80 |
| A | GLN152 |
| A | PHE153 |
| A | VAL154 |
| A | VAL172 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | GLU210 |
| A | HOH406 |
| A | HOH412 |
| A | HOH421 |
| D | SER124 |
| D | GLY125 |
| D | SER126 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue 3QA B 301 |
| Chain | Residue |
| A | PHE107 |
| A | HIS109 |
| A | PRO115 |
| B | ALA9 |
| B | MET10 |
| B | ILE52 |
| B | VAL78 |
| B | ALA79 |
| B | GLY80 |
| B | GLN152 |
| B | PHE153 |
| B | VAL154 |
| B | VAL172 |
| B | GLU173 |
| B | MET174 |
| B | GLU175 |
| B | SER197 |
| B | ASP198 |
| B | ALA200 |
| B | PHE208 |
| B | HOH403 |
| B | HOH425 |
| B | HOH451 |
| C | ASN136 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | GLU210 |
| B | HOH419 |
| B | HOH422 |
| C | SER124 |
| C | GLY125 |
| C | SER126 |
| C | PRO189 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue 3QA C 301 |
| Chain | Residue |
| C | ALA9 |
| C | GLU12 |
| C | ILE52 |
| C | VAL78 |
| C | ALA79 |
| C | GLY80 |
| C | PHE153 |
| C | VAL154 |
| C | VAL172 |
| C | GLU173 |
| C | MET174 |
| C | GLU175 |
| C | SER197 |
| C | ASP198 |
| C | ALA200 |
| C | PHE208 |
| C | HOH463 |
| C | HOH524 |
| D | PHE107 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | binding site for residue 3QA D 301 |
| Chain | Residue |
| C | PHE107 |
| D | ALA9 |
| D | GLU12 |
| D | ILE52 |
| D | VAL78 |
| D | ALA79 |
| D | GLY80 |
| D | PHE153 |
| D | VAL154 |
| D | VAL172 |
| D | GLU173 |
| D | MET174 |
| D | GLU175 |
| D | SER197 |
| D | ASP198 |
| D | ALA200 |
| D | PHE208 |
| D | HOH443 |
| D | HOH547 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20954236","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"20954236","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
