4WK6
Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (FabG) (G141A) from Vibrio cholerae in complex with NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0051287 | molecular_function | NAD binding |
| C | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0051287 | molecular_function | NAD binding |
| D | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue NDP A 301 |
| Chain | Residue |
| A | GLY16 |
| A | SER18 |
| A | THR41 |
| A | LEU62 |
| A | ASN63 |
| A | VAL64 |
| A | ILE93 |
| A | HOH419 |
| A | HOH426 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue NDP B 301 |
| Chain | Residue |
| A | ARG101 |
| B | GLY16 |
| B | SER18 |
| B | ARG19 |
| B | THR41 |
| B | LEU62 |
| B | ASN63 |
| B | VAL64 |
| B | ALA91 |
| B | GLY92 |
| B | ILE93 |
| B | THR113 |
| B | ASP191 |
| B | HOH416 |
| B | HOH424 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue NDP C 301 |
| Chain | Residue |
| C | GLY16 |
| C | SER18 |
| C | ARG19 |
| C | ALA40 |
| C | THR41 |
| C | LEU62 |
| C | ASN63 |
| C | VAL64 |
| C | ALA91 |
| C | GLY92 |
| C | ILE93 |
| C | HOH404 |
| C | HOH425 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue NDP D 301 |
| Chain | Residue |
| D | GLY16 |
| D | SER18 |
| D | ARG19 |
| D | THR41 |
| D | LEU62 |
| D | ASN63 |
| D | VAL64 |
| D | ALA91 |
| D | GLY92 |
| D | ILE93 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue 1PE D 302 |
| Chain | Residue |
| C | HIS240 |
| C | ASN242 |
| C | TYR246 |
| D | LYS167 |
| D | GLU237 |
| D | THR238 |
| D | HIS240 |
| D | HOH414 |
| D | HOH415 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvvgtmgnagQanYAAAKAGViGFTkSMA |
| Chain | Residue | Details |
| A | SER142-ALA170 |
