4WHA

Lipoxygenase-1 (soybean) L546A/L754A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016165	molecular_function	linoleate 13S-lipoxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0019395	biological_process	fatty acid oxidation
A	0031408	biological_process	oxylipin biosynthetic process
A	0034440	biological_process	lipid oxidation
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0102299	molecular_function	linolenate 9R-lipoxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue FE A 901

Chain	Residue
A	HIS499
A	HIS504
A	HIS690
A	ASN694
A	ILE839
A	HOH1352

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 902

Chain	Residue
A	VAL520
A	LYS526
A	HOH1376
A	ALA145
A	ASN146
A	HIS147

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 903

Chain	Residue
A	ASP291
A	GLY295
A	GLY296
A	LYS298
A	HOH1015
A	HOH1283

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 904

Chain	Residue
A	ILE412
A	ALA569
A	HOH1385
A	HOH1453
A	HOH1590
A	HOH1995

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 905

Chain	Residue
A	ASN190
A	GLY223
A	PRO229
A	HOH1403

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 906

Chain	Residue
A	HIS499
A	HOH1679
A	HOH1848

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 907

Chain	Residue
A	MET341
A	HIS730
A	HOH1246
A	HOH1603
A	HOH1739
A	HOH1855

---

site_id	AC8
Number of Residues	8
Details	binding site for residue EDO A 908

Chain	Residue
A	GLU344
A	ARG438
A	ASP440
A	THR442
A	LEU443
A	LYS444
A	HOH1160
A	HOH1400

---

site_id	AC9
Number of Residues	9
Details	binding site for residue ACT A 909

Chain	Residue
A	PHE286
A	HIS290
A	GLN337
A	TRP340
A	MET341
A	MET705
A	HOH1113
A	HOH1382
A	HOH1769

---

site_id	AD1
Number of Residues	8
Details	binding site for residue ACT A 910

Chain	Residue
A	THR555
A	THR556
A	ALA710
A	PRO743
A	HOH1312
A	HOH1335
A	HOH1440
A	HOH1993

---

site_id	AD2
Number of Residues	8
Details	binding site for residue ACT A 911

Chain	Residue
A	ASP440
A	ASP607
A	SER804
A	LEU805
A	GLY807
A	ASN808
A	HOH1407
A	HOH1985

---

site_id	AD3
Number of Residues	2
Details	binding site for residue ACT A 912

Chain	Residue
A	PRO664
A	TRP665

---

site_id	AD4
Number of Residues	9
Details	binding site for residue ACT A 913

Chain	Residue
A	LEU480
A	LYS483
A	ALA484
A	ILE487
A	MET705
A	TYR734
A	HOH1209
A	HOH1346
A	HOH1937

---

site_id	AD5
Number of Residues	9
Details	binding site for residue ACT A 914

Chain	Residue
A	GLU315
A	LEU316
A	TYR317
A	ARG318
A	PRO328
A	GLU752
A	ACT916
A	HOH1125
A	HOH1150

---

site_id	AD6
Number of Residues	7
Details	binding site for residue ACT A 915

Chain	Residue
A	ASP389
A	LEU390
A	ASP391
A	GLY392
A	TYR393
A	HOH1080
A	HOH1134

---

site_id	AD7
Number of Residues	8
Details	binding site for residue ACT A 916

Chain	Residue
A	LYS326
A	PRO328
A	ACT914
A	HOH1005
A	HOH1125
A	HOH1150
A	THR211
A	ARG318

---

Functional Information from PROSITE/UniProt

site_id	PS00081
Number of Residues	11
Details	LIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. LHPIyKLLtPH

Chain	Residue	Details
A	LEU521-HIS531

---

site_id	PS00711
Number of Residues	15
Details	LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HQlmsHwLNTHAAmE

Chain	Residue	Details
A	HIS494-GLU508

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	691
Details	Domain: {"description":"Lipoxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00726","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8502991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2SBL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8502991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2SBL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---