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4WD4

Crystal structure of human HO1 H25R

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001935biological_processendothelial cell proliferation
A0002246biological_processwound healing involved in inflammatory response
A0002686biological_processnegative regulation of leukocyte migration
A0004392molecular_functionheme oxygenase (decyclizing) activity
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006357biological_processregulation of transcription by RNA polymerase II
A0006788biological_processheme oxidation
A0006879biological_processintracellular iron ion homeostasis
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0014806biological_processsmooth muscle hyperplasia
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016239biological_processpositive regulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016491molecular_functionoxidoreductase activity
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0032722biological_processpositive regulation of chemokine production
A0034101biological_processerythrocyte homeostasis
A0034383biological_processlow-density lipoprotein particle clearance
A0034605biological_processcellular response to heat
A0035094biological_processresponse to nicotine
A0035556biological_processintracellular signal transduction
A0042167biological_processheme catabolic process
A0042168biological_processheme metabolic process
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0045765biological_processregulation of angiogenesis
A0045766biological_processpositive regulation of angiogenesis
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0071243biological_processcellular response to arsenic-containing substance
A0071276biological_processcellular response to cadmium ion
A0072719biological_processcellular response to cisplatin
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0110076biological_processnegative regulation of ferroptosis
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A1904019biological_processepithelial cell apoptotic process
A1904037biological_processpositive regulation of epithelial cell apoptotic process
B0001525biological_processangiogenesis
B0001935biological_processendothelial cell proliferation
B0002246biological_processwound healing involved in inflammatory response
B0002686biological_processnegative regulation of leukocyte migration
B0004392molecular_functionheme oxygenase (decyclizing) activity
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0006357biological_processregulation of transcription by RNA polymerase II
B0006788biological_processheme oxidation
B0006879biological_processintracellular iron ion homeostasis
B0006915biological_processapoptotic process
B0006979biological_processresponse to oxidative stress
B0014806biological_processsmooth muscle hyperplasia
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016239biological_processpositive regulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016491molecular_functionoxidoreductase activity
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0032722biological_processpositive regulation of chemokine production
B0034101biological_processerythrocyte homeostasis
B0034383biological_processlow-density lipoprotein particle clearance
B0034605biological_processcellular response to heat
B0035094biological_processresponse to nicotine
B0035556biological_processintracellular signal transduction
B0042167biological_processheme catabolic process
B0042168biological_processheme metabolic process
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0045765biological_processregulation of angiogenesis
B0045766biological_processpositive regulation of angiogenesis
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0071243biological_processcellular response to arsenic-containing substance
B0071276biological_processcellular response to cadmium ion
B0072719biological_processcellular response to cisplatin
B0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
B0110076biological_processnegative regulation of ferroptosis
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B1904019biological_processepithelial cell apoptotic process
B1904037biological_processpositive regulation of epithelial cell apoptotic process
C0001525biological_processangiogenesis
C0001935biological_processendothelial cell proliferation
C0002246biological_processwound healing involved in inflammatory response
C0002686biological_processnegative regulation of leukocyte migration
C0004392molecular_functionheme oxygenase (decyclizing) activity
C0005198molecular_functionstructural molecule activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005741cellular_componentmitochondrial outer membrane
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0006357biological_processregulation of transcription by RNA polymerase II
C0006788biological_processheme oxidation
C0006879biological_processintracellular iron ion homeostasis
C0006915biological_processapoptotic process
C0006979biological_processresponse to oxidative stress
C0014806biological_processsmooth muscle hyperplasia
C0016020cellular_componentmembrane
C0016236biological_processmacroautophagy
C0016239biological_processpositive regulation of macroautophagy
C0016242biological_processnegative regulation of macroautophagy
C0016491molecular_functionoxidoreductase activity
C0019899molecular_functionenzyme binding
C0020037molecular_functionheme binding
C0032722biological_processpositive regulation of chemokine production
C0034101biological_processerythrocyte homeostasis
C0034383biological_processlow-density lipoprotein particle clearance
C0034605biological_processcellular response to heat
C0035094biological_processresponse to nicotine
C0035556biological_processintracellular signal transduction
C0042167biological_processheme catabolic process
C0042168biological_processheme metabolic process
C0042542biological_processresponse to hydrogen peroxide
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0045765biological_processregulation of angiogenesis
C0045766biological_processpositive regulation of angiogenesis
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0048661biological_processpositive regulation of smooth muscle cell proliferation
C0048662biological_processnegative regulation of smooth muscle cell proliferation
C0060586biological_processmulticellular organismal-level iron ion homeostasis
C0071243biological_processcellular response to arsenic-containing substance
C0071276biological_processcellular response to cadmium ion
C0072719biological_processcellular response to cisplatin
C0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
C0110076biological_processnegative regulation of ferroptosis
C1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
C1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
C1904019biological_processepithelial cell apoptotic process
C1904037biological_processpositive regulation of epithelial cell apoptotic process
D0001525biological_processangiogenesis
D0001935biological_processendothelial cell proliferation
D0002246biological_processwound healing involved in inflammatory response
D0002686biological_processnegative regulation of leukocyte migration
D0004392molecular_functionheme oxygenase (decyclizing) activity
D0005198molecular_functionstructural molecule activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005741cellular_componentmitochondrial outer membrane
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0006357biological_processregulation of transcription by RNA polymerase II
D0006788biological_processheme oxidation
D0006879biological_processintracellular iron ion homeostasis
D0006915biological_processapoptotic process
D0006979biological_processresponse to oxidative stress
D0014806biological_processsmooth muscle hyperplasia
D0016020cellular_componentmembrane
D0016236biological_processmacroautophagy
D0016239biological_processpositive regulation of macroautophagy
D0016242biological_processnegative regulation of macroautophagy
D0016491molecular_functionoxidoreductase activity
D0019899molecular_functionenzyme binding
D0020037molecular_functionheme binding
D0032722biological_processpositive regulation of chemokine production
D0034101biological_processerythrocyte homeostasis
D0034383biological_processlow-density lipoprotein particle clearance
D0034605biological_processcellular response to heat
D0035094biological_processresponse to nicotine
D0035556biological_processintracellular signal transduction
D0042167biological_processheme catabolic process
D0042168biological_processheme metabolic process
D0042542biological_processresponse to hydrogen peroxide
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0045765biological_processregulation of angiogenesis
D0045766biological_processpositive regulation of angiogenesis
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0048662biological_processnegative regulation of smooth muscle cell proliferation
D0060586biological_processmulticellular organismal-level iron ion homeostasis
D0071243biological_processcellular response to arsenic-containing substance
D0071276biological_processcellular response to cadmium ion
D0072719biological_processcellular response to cisplatin
D0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
D0110076biological_processnegative regulation of ferroptosis
D1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
D1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
D1904019biological_processepithelial cell apoptotic process
D1904037biological_processpositive regulation of epithelial cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue HEM A 300
ChainResidue
AGLU29
APHE207
AASN210
AMET34
AGLN38
ATYR134
AGLY139
ASER142
ALEU147
ALYS179
AARG183

site_idAC2
Number of Residues10
Detailsbinding site for residue HEM B 301
ChainResidue
BLYS18
BGLU29
BMET34
BTYR134
BTHR135
BGLY139
BSER142
BARG183
BPHE207
BPHE214

site_idAC3
Number of Residues2
Detailsbinding site for residue EPE B 302
ChainResidue
AHIS223
BLYS48

site_idAC4
Number of Residues12
Detailsbinding site for residue HEM C 300
ChainResidue
CGLU29
CMET34
CGLN38
CTYR134
CTHR135
CGLY139
CSER142
CGLY143
CLEU147
CARG183
CASN210
CPHE214

site_idAC5
Number of Residues12
Detailsbinding site for residue HEM D 301
ChainResidue
DLYS18
DGLU29
DMET34
DGLN38
DTYR134
DTHR135
DGLY139
DSER142
DLEU147
DLYS179
DPHE207
DASN210

site_idAC6
Number of Residues3
Detailsbinding site for residue EPE D 302
ChainResidue
CHIS223
DLYS48
DTYR97

Functional Information from PROSITE/UniProt
site_idPS00593
Number of Residues11
DetailsHEME_OXYGENASE Heme oxygenase signature. LVAHAYTRYLG
ChainResidueDetails
ALEU129-GLY139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1056
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:22419571
ChainResidueDetails
AMET1-ALA265
BMET1-ALA265
CMET1-ALA265
DMET1-ALA265

site_idSWS_FT_FI2
Number of Residues88
DetailsTRANSMEM: Helical; Anchor for type IV membrane protein => ECO:0000255
ChainResidueDetails
APRO266-MET288
BPRO266-MET288
CPRO266-MET288
DPRO266-MET288

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:12842469, ECO:0007744|PDB:1OZW
ChainResidueDetails
ALYS18
DLYS18
DTYR134
DARG183
ATYR134
AARG183
BLYS18
BTYR134
BARG183
CLYS18
CTYR134
CARG183

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:12842469, ECO:0007744|PDB:1OZW
ChainResidueDetails
AARG25
BARG25
CARG25
DARG25

site_idSWS_FT_FI5
Number of Residues4
DetailsSITE: Important for catalytic activity => ECO:0000269|PubMed:11121422
ChainResidueDetails
AASP140
BASP140
CASP140
DASP140

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER229
BSER229
CSER229
DSER229

223166

PDB entries from 2024-07-31

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