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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4WBO

Bovine G Protein Coupled Receptor Kinase 1 in Complex with Amlexanox

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001750cellular_componentphotoreceptor outer segment
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004703molecular_functionG protein-coupled receptor kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0006468biological_processprotein phosphorylation
A0007165biological_processsignal transduction
A0007601biological_processvisual perception
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0022400biological_processregulation of opsin-mediated signaling pathway
A0050254molecular_functionrhodopsin kinase activity
A0097381cellular_componentphotoreceptor disc membrane
B0000166molecular_functionnucleotide binding
B0001750cellular_componentphotoreceptor outer segment
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004703molecular_functionG protein-coupled receptor kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0006468biological_processprotein phosphorylation
B0007165biological_processsignal transduction
B0007601biological_processvisual perception
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0022400biological_processregulation of opsin-mediated signaling pathway
B0050254molecular_functionrhodopsin kinase activity
B0097381cellular_componentphotoreceptor disc membrane
C0000166molecular_functionnucleotide binding
C0001750cellular_componentphotoreceptor outer segment
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004703molecular_functionG protein-coupled receptor kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0006468biological_processprotein phosphorylation
C0007165biological_processsignal transduction
C0007601biological_processvisual perception
C0009966biological_processregulation of signal transduction
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0022400biological_processregulation of opsin-mediated signaling pathway
C0050254molecular_functionrhodopsin kinase activity
C0097381cellular_componentphotoreceptor disc membrane
D0000166molecular_functionnucleotide binding
D0001750cellular_componentphotoreceptor outer segment
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004703molecular_functionG protein-coupled receptor kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0006468biological_processprotein phosphorylation
D0007165biological_processsignal transduction
D0007601biological_processvisual perception
D0009966biological_processregulation of signal transduction
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016740molecular_functiontransferase activity
D0022400biological_processregulation of opsin-mediated signaling pathway
D0050254molecular_functionrhodopsin kinase activity
D0097381cellular_componentphotoreceptor disc membrane
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue ANW A 601
ChainResidue
AALA214
AMET264
ATHR265
AMET267
ALEU321
AALA478
AHOH706
site_idAC2
Number of Residues4
Detailsbinding site for residue CL A 602
ChainResidue
BARG170
BGLN173
ASER165
ALEU166
site_idAC3
Number of Residues7
Detailsbinding site for residue ANW B 601
ChainResidue
BLEU193
BALA214
BTHR265
BMET267
BASN268
BLEU321
BALA478
site_idAC4
Number of Residues3
Detailsbinding site for residue CL B 602
ChainResidue
AARG170
AGLN173
BLEU166
site_idAC5
Number of Residues6
Detailsbinding site for residue ANW C 601
ChainResidue
CALA214
CTHR265
CMET267
CASN268
CHOH703
CHOH704
site_idAC6
Number of Residues3
Detailsbinding site for residue CL C 602
ChainResidue
CLEU166
DARG170
DGLN173
site_idAC7
Number of Residues10
Detailsbinding site for residue ANW D 601
ChainResidue
DLEU193
DALA214
DMET264
DTHR265
DMET267
DLEU321
DTYR477
DALA478
DHOH701
DHOH705
site_idAC8
Number of Residues4
Detailsbinding site for residue CL D 602
ChainResidue
CARG170
CGLN173
DSER165
DLEU166
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGGFGEVFaCqmkatgkl..........YACK
ChainResidueDetails
ALEU193-LYS216
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNVLL
ChainResidueDetails
AILE310-LEU322
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues342
DetailsDomain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1060
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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