Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4WBO

Bovine G Protein Coupled Receptor Kinase 1 in Complex with Amlexanox

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001750	cellular_component	photoreceptor outer segment
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004703	molecular_function	G protein-coupled receptor kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0007601	biological_process	visual perception
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0022400	biological_process	regulation of opsin-mediated signaling pathway
A	0050254	molecular_function	rhodopsin kinase activity
A	0097381	cellular_component	photoreceptor disc membrane
B	0001750	cellular_component	photoreceptor outer segment
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004703	molecular_function	G protein-coupled receptor kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006468	biological_process	protein phosphorylation
B	0007165	biological_process	signal transduction
B	0007601	biological_process	visual perception
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0022400	biological_process	regulation of opsin-mediated signaling pathway
B	0050254	molecular_function	rhodopsin kinase activity
B	0097381	cellular_component	photoreceptor disc membrane
C	0001750	cellular_component	photoreceptor outer segment
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004703	molecular_function	G protein-coupled receptor kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006468	biological_process	protein phosphorylation
C	0007165	biological_process	signal transduction
C	0007601	biological_process	visual perception
C	0009966	biological_process	regulation of signal transduction
C	0016020	cellular_component	membrane
C	0022400	biological_process	regulation of opsin-mediated signaling pathway
C	0050254	molecular_function	rhodopsin kinase activity
C	0097381	cellular_component	photoreceptor disc membrane
D	0001750	cellular_component	photoreceptor outer segment
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004703	molecular_function	G protein-coupled receptor kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006468	biological_process	protein phosphorylation
D	0007165	biological_process	signal transduction
D	0007601	biological_process	visual perception
D	0009966	biological_process	regulation of signal transduction
D	0016020	cellular_component	membrane
D	0022400	biological_process	regulation of opsin-mediated signaling pathway
D	0050254	molecular_function	rhodopsin kinase activity
D	0097381	cellular_component	photoreceptor disc membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue ANW A 601

Chain	Residue
A	ALA214
A	MET264
A	THR265
A	MET267
A	LEU321
A	ALA478
A	HOH706

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 602

Chain	Residue
B	ARG170
B	GLN173
A	SER165
A	LEU166

site_id	AC3
Number of Residues	7
Details	binding site for residue ANW B 601

Chain	Residue
B	LEU193
B	ALA214
B	THR265
B	MET267
B	ASN268
B	LEU321
B	ALA478

site_id	AC4
Number of Residues	3
Details	binding site for residue CL B 602

Chain	Residue
A	ARG170
A	GLN173
B	LEU166

site_id	AC5
Number of Residues	6
Details	binding site for residue ANW C 601

Chain	Residue
C	ALA214
C	THR265
C	MET267
C	ASN268
C	HOH703
C	HOH704

site_id	AC6
Number of Residues	3
Details	binding site for residue CL C 602

Chain	Residue
C	LEU166
D	ARG170
D	GLN173

site_id	AC7
Number of Residues	10
Details	binding site for residue ANW D 601

Chain	Residue
D	LEU193
D	ALA214
D	MET264
D	THR265
D	MET267
D	LEU321
D	TYR477
D	ALA478
D	HOH701
D	HOH705

site_id	AC8
Number of Residues	4
Details	binding site for residue CL D 602

Chain	Residue
C	ARG170
C	GLN173
D	SER165
D	LEU166

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGGFGEVFaCqmkatgkl..........YACK

Chain	Residue	Details
A	LEU193-LYS216

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNVLL

Chain	Residue	Details
A	ILE310-LEU322

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	342
Details	Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1060
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18339619","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details