4WA8

Methanopyrus Kandleri FEN-1 nuclease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005737	cellular_component	cytoplasm
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0008409	molecular_function	5'-3' exonuclease activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0017108	molecular_function	5'-flap endonuclease activity
A	0030145	molecular_function	manganese ion binding
A	0043137	biological_process	DNA replication, removal of RNA primer
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003677	molecular_function	DNA binding
B	0003824	molecular_function	catalytic activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
B	0004527	molecular_function	exonuclease activity
B	0005737	cellular_component	cytoplasm
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0008409	molecular_function	5'-3' exonuclease activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0017108	molecular_function	5'-flap endonuclease activity
B	0030145	molecular_function	manganese ion binding
B	0043137	biological_process	DNA replication, removal of RNA primer
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CL A 401

Chain	Residue
A	TYR63
A	PHE316
A	SER317

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site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 402

Chain	Residue
A	ARG320
A	HOH505
A	HOH507
A	HOH510

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site_id	AC3
Number of Residues	3
Details	binding site for residue CL B 401

Chain	Residue
B	HOH510
B	ARG320
B	HOH505

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site_id	AC4
Number of Residues	3
Details	binding site for residue CL B 402

Chain	Residue
B	TYR63
B	PHE316
B	SER317

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Functional Information from PROSITE/UniProt

site_id	PS00841
Number of Residues	15
Details	XPG_1 XPG protein signature 1. IKPvYVFDGepPdLK

Chain	Residue	Details
A	ILE73-LYS87

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00614

Chain	Residue	Details
B	ASP80
B	GLU149
B	GLU151
B	ASP170
B	ASP172
B	ASP234
A	ASP28
A	ASP80
A	GLU149
A	GLU151
A	ASP170
A	ASP172
A	ASP234
B	ASP28

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