4W5K
Structure of a mitochondrial aspartate aminotransferase from Trypanosoma brucei, K237A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004021 | molecular_function | L-alanine:2-oxoglutarate aminotransferase activity |
| A | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0031981 | cellular_component | nuclear lumen |
| A | 0097014 | cellular_component | ciliary plasm |
| B | 0004021 | molecular_function | L-alanine:2-oxoglutarate aminotransferase activity |
| B | 0004069 | molecular_function | L-aspartate:2-oxoglutarate aminotransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0031981 | cellular_component | nuclear lumen |
| B | 0097014 | cellular_component | ciliary plasm |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue PLP A 500 |
| Chain | Residue |
| A | GLY91 |
| A | SER236 |
| A | ARG245 |
| B | TYR54 |
| B | HOH935 |
| A | GLY92 |
| A | THR93 |
| A | TYR120 |
| A | ASN173 |
| A | ASP201 |
| A | ALA203 |
| A | TYR204 |
| A | SER234 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MLT A 501 |
| Chain | Residue |
| A | HIS181 |
| A | ARG185 |
| A | PHE217 |
| A | HOH604 |
| B | VAL326 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | LYS145 |
| A | ASP328 |
| A | TRP329 |
| A | HIS331 |
| A | THR342 |
| A | GLY343 |
| A | HOH634 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue PLP B 500 |
| Chain | Residue |
| A | TYR54 |
| B | GLY91 |
| B | GLY92 |
| B | THR93 |
| B | TYR120 |
| B | ASN173 |
| B | ASP201 |
| B | ALA203 |
| B | TYR204 |
| B | SER234 |
| B | SER236 |
| B | ARG245 |
| B | HOH975 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MLT B 501 |
| Chain | Residue |
| A | VAL326 |
| B | HIS181 |
| B | ARG185 |
| B | PHE217 |
| B | HOH602 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | LYS145 |
| B | ASP328 |
| B | TRP329 |
| B | HIS331 |
| B | THR342 |
| B | GLY343 |
| B | HOH627 |
