Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4W4U

Structure of yeast SAGA DUBm with Sgf73 Y57A mutant at 2.8 angstroms resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016579	biological_process	protein deubiquitination
A	0046872	molecular_function	metal ion binding
B	0000124	cellular_component	SAGA complex
B	0000932	cellular_component	P-body
B	0003713	molecular_function	transcription coactivator activity
B	0005634	cellular_component	nucleus
B	0005643	cellular_component	nuclear pore
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0006406	biological_process	mRNA export from nucleus
B	0015031	biological_process	protein transport
B	0043229	cellular_component	intracellular organelle
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0051028	biological_process	mRNA transport
B	0070390	cellular_component	transcription export complex 2
B	0071819	cellular_component	DUBm complex
C	0000124	cellular_component	SAGA complex
C	0003713	molecular_function	transcription coactivator activity
C	0005634	cellular_component	nucleus
C	0006325	biological_process	chromatin organization
C	0008270	molecular_function	zinc ion binding
C	0008301	molecular_function	DNA binding, bending
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046872	molecular_function	metal ion binding
C	0070461	cellular_component	SAGA-type complex
C	0071819	cellular_component	DUBm complex
D	0004843	molecular_function	cysteine-type deubiquitinase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity
D	0008270	molecular_function	zinc ion binding
D	0016579	biological_process	protein deubiquitination
D	0046872	molecular_function	metal ion binding
F	0000124	cellular_component	SAGA complex
F	0000932	cellular_component	P-body
F	0003713	molecular_function	transcription coactivator activity
F	0005634	cellular_component	nucleus
F	0005643	cellular_component	nuclear pore
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0006325	biological_process	chromatin organization
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006406	biological_process	mRNA export from nucleus
F	0015031	biological_process	protein transport
F	0043229	cellular_component	intracellular organelle
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0051028	biological_process	mRNA transport
F	0070390	cellular_component	transcription export complex 2
F	0071819	cellular_component	DUBm complex
G	0000124	cellular_component	SAGA complex
G	0003713	molecular_function	transcription coactivator activity
G	0005634	cellular_component	nucleus
G	0006325	biological_process	chromatin organization
G	0008270	molecular_function	zinc ion binding
G	0008301	molecular_function	DNA binding, bending
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0046872	molecular_function	metal ion binding
G	0070461	cellular_component	SAGA-type complex
G	0071819	cellular_component	DUBm complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS4
A	HIS6
A	CYS96
A	CYS99

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS46
A	CYS49
A	CYS68
A	HIS73

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 503

Chain	Residue
A	CYS271
A	CYS273
A	HIS276
A	HIS250

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 504

Chain	Residue
A	CYS60
A	CYS63
A	HIS77
A	HIS83

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 505

Chain	Residue
A	HIS170
A	CYS174
A	CYS182
A	CYS185

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 506

Chain	Residue
A	CYS289
A	CYS292
A	CYS336
A	CYS339

site_id	AC7
Number of Residues	3
Details	binding site for residue ZN E 101

Chain	Residue
E	CYS78
E	CYS81
E	HIS93

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN D 501

Chain	Residue
D	CYS4
D	HIS6
D	CYS96
D	CYS99

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN D 502

Chain	Residue
D	HIS170
D	CYS174
D	CYS182
D	CYS185

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN D 503

Chain	Residue
D	HIS250
D	CYS271
D	CYS273
D	HIS276

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN D 504

Chain	Residue
D	CYS46
D	CYS49
D	CYS68
D	HIS73

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN D 505

Chain	Residue
D	CYS60
D	CYS63
D	HIS77
D	HIS83

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN H 101

Chain	Residue
H	CYS78
H	CYS81
H	HIS93
H	HOH202

Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLinmGStCFMSSiLQ

Chain	Residue	Details
A	GLY138-GLN153

site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YeLiGIvsHkGtvne..GHY

Chain	Residue	Details
A	TYR411-TYR428

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)