4V5Z
Structure of a mammalian 80S ribosome obtained by docking homology models of the RNA and proteins into an 8.7 A cryo-EM map
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| Aa | 0043022 | molecular_function | ribosome binding |
| Aa | 0045182 | molecular_function | translation regulator activity |
| Ab | 0003735 | molecular_function | structural constituent of ribosome |
| Ab | 0005055 | molecular_function | laminin receptor activity |
| Ab | 0005840 | cellular_component | ribosome |
| Ab | 0006412 | biological_process | translation |
| Ab | 0015935 | cellular_component | small ribosomal subunit |
| Ac | 0003723 | molecular_function | RNA binding |
| Ac | 0003735 | molecular_function | structural constituent of ribosome |
| Ac | 0006412 | biological_process | translation |
| Ac | 0015935 | cellular_component | small ribosomal subunit |
| Ad | 0003723 | molecular_function | RNA binding |
| Ad | 0003735 | molecular_function | structural constituent of ribosome |
| Ad | 0006412 | biological_process | translation |
| Ad | 0015935 | cellular_component | small ribosomal subunit |
| Ad | 0019843 | molecular_function | rRNA binding |
| Ae | 0003723 | molecular_function | RNA binding |
| Ae | 0003735 | molecular_function | structural constituent of ribosome |
| Ae | 0005840 | cellular_component | ribosome |
| Ae | 0006412 | biological_process | translation |
| Ae | 0015935 | cellular_component | small ribosomal subunit |
| Ag | 0003723 | molecular_function | RNA binding |
| Ag | 0003735 | molecular_function | structural constituent of ribosome |
| Ag | 0006412 | biological_process | translation |
| Ag | 0015935 | cellular_component | small ribosomal subunit |
| Ah | 0003735 | molecular_function | structural constituent of ribosome |
| Ah | 0005840 | cellular_component | ribosome |
| Ah | 0006412 | biological_process | translation |
| Ai | 0003735 | molecular_function | structural constituent of ribosome |
| Ai | 0005840 | cellular_component | ribosome |
| Ai | 0006412 | biological_process | translation |
| Aj | 0003723 | molecular_function | RNA binding |
| Aj | 0003735 | molecular_function | structural constituent of ribosome |
| Aj | 0005840 | cellular_component | ribosome |
| Aj | 0006412 | biological_process | translation |
| Aj | 0015935 | cellular_component | small ribosomal subunit |
| Ak | 0003735 | molecular_function | structural constituent of ribosome |
| Ak | 0005840 | cellular_component | ribosome |
| Ak | 0006412 | biological_process | translation |
| Al | 0003735 | molecular_function | structural constituent of ribosome |
| Al | 0005840 | cellular_component | ribosome |
| Al | 0006412 | biological_process | translation |
| Al | 0015935 | cellular_component | small ribosomal subunit |
| Am | 0003676 | molecular_function | nucleic acid binding |
| Am | 0003723 | molecular_function | RNA binding |
| Am | 0003735 | molecular_function | structural constituent of ribosome |
| Am | 0005840 | cellular_component | ribosome |
| Am | 0006412 | biological_process | translation |
| An | 0003735 | molecular_function | structural constituent of ribosome |
| An | 0005840 | cellular_component | ribosome |
| An | 0006412 | biological_process | translation |
| An | 0008270 | molecular_function | zinc ion binding |
| Ao | 0003735 | molecular_function | structural constituent of ribosome |
| Ao | 0005840 | cellular_component | ribosome |
| Ao | 0006412 | biological_process | translation |
| Aq | 0003735 | molecular_function | structural constituent of ribosome |
| Aq | 0005840 | cellular_component | ribosome |
| Aq | 0006412 | biological_process | translation |
| As | 0003723 | molecular_function | RNA binding |
| As | 0003735 | molecular_function | structural constituent of ribosome |
| As | 0005840 | cellular_component | ribosome |
| As | 0006412 | biological_process | translation |
| As | 0015935 | cellular_component | small ribosomal subunit |
| B2 | 0003735 | molecular_function | structural constituent of ribosome |
| B2 | 0005840 | cellular_component | ribosome |
| B2 | 0006412 | biological_process | translation |
| B3 | 0003735 | molecular_function | structural constituent of ribosome |
| B3 | 0005840 | cellular_component | ribosome |
| B3 | 0006412 | biological_process | translation |
| B4 | 0003735 | molecular_function | structural constituent of ribosome |
| B4 | 0005840 | cellular_component | ribosome |
| B4 | 0006412 | biological_process | translation |
| B5 | 0003723 | molecular_function | RNA binding |
| B5 | 0003735 | molecular_function | structural constituent of ribosome |
| B5 | 0006412 | biological_process | translation |
| B5 | 0015934 | cellular_component | large ribosomal subunit |
| B6 | 0003723 | molecular_function | RNA binding |
| B6 | 0003735 | molecular_function | structural constituent of ribosome |
| B6 | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| B9 | 0003735 | molecular_function | structural constituent of ribosome |
| B9 | 0005840 | cellular_component | ribosome |
| B9 | 0006412 | biological_process | translation |
| Ba | 0003723 | molecular_function | RNA binding |
| Ba | 0003735 | molecular_function | structural constituent of ribosome |
| Ba | 0005840 | cellular_component | ribosome |
| Ba | 0006412 | biological_process | translation |
| Ba | 0015934 | cellular_component | large ribosomal subunit |
| Bb | 0003735 | molecular_function | structural constituent of ribosome |
| Bb | 0005840 | cellular_component | ribosome |
| Bb | 0006412 | biological_process | translation |
| Bc | 0003735 | molecular_function | structural constituent of ribosome |
| Bc | 0005840 | cellular_component | ribosome |
| Bc | 0006412 | biological_process | translation |
| Bd | 0003735 | molecular_function | structural constituent of ribosome |
| Bd | 0005840 | cellular_component | ribosome |
| Bd | 0006412 | biological_process | translation |
| Be | 0003735 | molecular_function | structural constituent of ribosome |
| Be | 0005840 | cellular_component | ribosome |
| Be | 0006412 | biological_process | translation |
| Be | 0019843 | molecular_function | rRNA binding |
| Bf | 0042254 | biological_process | ribosome biogenesis |
| Bf | 1990904 | cellular_component | ribonucleoprotein complex |
| Bg | 0042254 | biological_process | ribosome biogenesis |
| Bh | 0003735 | molecular_function | structural constituent of ribosome |
| Bh | 0005840 | cellular_component | ribosome |
| Bh | 0006412 | biological_process | translation |
| Bi | 0003735 | molecular_function | structural constituent of ribosome |
| Bi | 0005840 | cellular_component | ribosome |
| Bi | 0006412 | biological_process | translation |
| Bj | 0003735 | molecular_function | structural constituent of ribosome |
| Bj | 0005840 | cellular_component | ribosome |
| Bj | 0006412 | biological_process | translation |
| Bj | 0015934 | cellular_component | large ribosomal subunit |
| Bk | 0003735 | molecular_function | structural constituent of ribosome |
| Bk | 0005840 | cellular_component | ribosome |
| Bk | 0006412 | biological_process | translation |
| Bl | 0003735 | molecular_function | structural constituent of ribosome |
| Bl | 0005840 | cellular_component | ribosome |
| Bl | 0006412 | biological_process | translation |
| Bl | 0015934 | cellular_component | large ribosomal subunit |
| Bm | 0003735 | molecular_function | structural constituent of ribosome |
| Bm | 0005840 | cellular_component | ribosome |
| Bm | 0006412 | biological_process | translation |
| Bn | 0003735 | molecular_function | structural constituent of ribosome |
| Bn | 0005840 | cellular_component | ribosome |
| Bn | 0006412 | biological_process | translation |
| Bn | 0008097 | molecular_function | 5S rRNA binding |
| Bo | 0003735 | molecular_function | structural constituent of ribosome |
| Bo | 0005840 | cellular_component | ribosome |
| Bo | 0006412 | biological_process | translation |
| Bp | 0003723 | molecular_function | RNA binding |
| Bp | 0003735 | molecular_function | structural constituent of ribosome |
| Bp | 0005840 | cellular_component | ribosome |
| Bp | 0006412 | biological_process | translation |
| Bp | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| Bq | 0003735 | molecular_function | structural constituent of ribosome |
| Bq | 0005840 | cellular_component | ribosome |
| Bq | 0006412 | biological_process | translation |
| Br | 0003735 | molecular_function | structural constituent of ribosome |
| Br | 0005840 | cellular_component | ribosome |
| Br | 0006412 | biological_process | translation |
| Br | 0015934 | cellular_component | large ribosomal subunit |
| Bs | 0003735 | molecular_function | structural constituent of ribosome |
| Bs | 0005840 | cellular_component | ribosome |
| Bs | 0006412 | biological_process | translation |
| Bs | 0019843 | molecular_function | rRNA binding |
| Bt | 0003723 | molecular_function | RNA binding |
| Bt | 0003735 | molecular_function | structural constituent of ribosome |
| Bt | 0005840 | cellular_component | ribosome |
| Bt | 0006412 | biological_process | translation |
| Bt | 0015934 | cellular_component | large ribosomal subunit |
| Bv | 0000463 | biological_process | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Bv | 0003735 | molecular_function | structural constituent of ribosome |
| Bv | 0005840 | cellular_component | ribosome |
| Bv | 0006412 | biological_process | translation |
| Bv | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| Bw | 0000463 | biological_process | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Bw | 0003735 | molecular_function | structural constituent of ribosome |
| Bw | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| Bx | 0003735 | molecular_function | structural constituent of ribosome |
| Bx | 0005840 | cellular_component | ribosome |
| Bx | 0006412 | biological_process | translation |
| By | 0003735 | molecular_function | structural constituent of ribosome |
| By | 0005840 | cellular_component | ribosome |
| By | 0006412 | biological_process | translation |
| Bz | 0003735 | molecular_function | structural constituent of ribosome |
| Bz | 0005840 | cellular_component | ribosome |
| Bz | 0006412 | biological_process | translation |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GESSGKNV |
| Chain | Residue | Details |
| Bc | GLY14-VAL21 |
| site_id | PS00939 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_L1E Ribosomal protein L1e signature. NttqKryAIcSALaCLSlpalvmsKGH |
| Chain | Residue | Details |
| Bc | ASN115-HIS141 |
| site_id | PS00527 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_S14 Ribosomal protein S14 signature. RvCsnrhglirkyg.LNMCRqCFR |
| Chain | Residue | Details |
| An | ARG22-ARG44 |
| site_id | PS00709 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_L30E_1 Ribosomal protein L30e signature 1. SgkyvlGyKqtLKmiRqGkaKlVIL |
| Chain | Residue | Details |
| B6 | SER24-LEU48 |
| site_id | PS00993 |
| Number of Residues | 21 |
| Details | RIBOSOMAL_L30E_2 Ribosomal protein L30e signature 2. ELGTacGKyyrvctLaIiDpG |
| Chain | Residue | Details |
| B6 | GLU80-GLY100 |
| site_id | PS01194 |
| Number of Residues | 24 |
| Details | RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGYVIYRiRVrRG |
| Chain | Residue | Details |
| Bm | ASP46-GLY69 |
| site_id | PS00323 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S19 Ribosomal protein S19 signature. NGKtfnqveIkpemIGhyLGEFsiT |
| Chain | Residue | Details |
| As | ASN98-THR122 |
| site_id | PS00056 |
| Number of Residues | 13 |
| Details | RIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgEcRPLS |
| Chain | Residue | Details |
| Aq | GLY123-SER135 |
| site_id | PS00361 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_S10 Ribosomal protein S10 signature. AkekNLkvkGPVrMPT |
| Chain | Residue | Details |
| Aj | ALA43-THR58 |
| site_id | PS01106 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L18E Ribosomal protein L18e signature. KrLfmSRtnRPpLSLsRM |
| Chain | Residue | Details |
| Bo | LYS48-MET65 |
| site_id | PS00526 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_L19E Ribosomal protein L19e signature. QKRLaSsvlrCGkkkVWLDP |
| Chain | Residue | Details |
| Bp | GLN7-PRO26 |
| site_id | PS01073 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L24E Ribosomal protein L24e signature. FsGykIyPGhGrrYaRtD |
| Chain | Residue | Details |
| Bu | PHE8-ASP25 |
| site_id | PS00632 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S4 Ribosomal protein S4 signature. LEsRLdnvVYRlgfAvSrrqARqLV |
| Chain | Residue | Details |
| Ad | LEU96-VAL120 |
| site_id | PS00475 |
| Number of Residues | 32 |
| Details | RIBOSOMAL_L15 Ribosomal protein L15 signature. KVLGkGkLpkqp.ViVkakfFSrrAeekIksvG |
| Chain | Residue | Details |
| Bl | LYS110-GLY141 |
| site_id | PS00646 |
| Number of Residues | 14 |
| Details | RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGlRHfwGlrVRGQ |
| Chain | Residue | Details |
| Am | ARG121-GLN134 |
| site_id | PS00464 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinpymsspCHIEMiL |
| Chain | Residue | Details |
| Br | ARG126-LEU150 |
| site_id | PS00634 |
| Number of Residues | 33 |
| Details | RIBOSOMAL_L30 Ribosomal protein L30 signature. VLqlLrLrQifNgTfvklnkasinMLriVepYI |
| Chain | Residue | Details |
| Bw | VAL130-ILE162 |
| site_id | PS01144 |
| Number of Residues | 15 |
| Details | RIBOSOMAL_L31E Ribosomal protein L31e signature. VRIDtrLNkAvWaKG |
| Chain | Residue | Details |
| Bx | VAL62-GLY76 |
| site_id | PS00049 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVIrqrksyrrk.DGvflyFedNagVI |
| Chain | Residue | Details |
| Bk | ALA79-ILE105 |
| site_id | PS01108 |
| Number of Residues | 19 |
| Details | RIBOSOMAL_L24 Ribosomal protein L24 signature. DDeVqVVrGhyKGqqiGkV |
| Chain | Residue | Details |
| Bt | ASP52-VAL70 |
| site_id | PS00585 |
| Number of Residues | 33 |
| Details | RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAfvAIGDhn.GhVGlGvkcsk.EVat.AI |
| Chain | Residue | Details |
| Ae | GLY27-ILE59 |
| site_id | PS00053 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_S8 Ribosomal protein S8 signature. GfiVLTTSaGIMdheeAR |
| Chain | Residue | Details |
| Ah | GLY100-ARG117 |
| site_id | PS00783 |
| Number of Residues | 24 |
| Details | RIBOSOMAL_L13 Ribosomal protein L13 signature. VRGMLPhktkrGQaaldrLkVFdG |
| Chain | Residue | Details |
| Bj | VAL83-GLY106 |
| site_id | PS01171 |
| Number of Residues | 26 |
| Details | RIBOSOMAL_L21E Ribosomal protein L21e signature. GDiVdikgmgtvqk.GmpHkcYhGkTG |
| Chain | Residue | Details |
| Bq | GLY36-GLY61 |
| site_id | PS00052 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtnsMMmhgrnnGKKlmtvrIVkhA |
| Chain | Residue | Details |
| Ag | GLU70-ALA96 |
| site_id | PS00474 |
| Number of Residues | 24 |
| Details | RIBOSOMAL_L3 Ribosomal protein L3 signature. FgqdemiDviGvTkGKGykGvtsR |
| Chain | Residue | Details |
| Bb | PHE210-ARG233 |
| site_id | PS00362 |
| Number of Residues | 31 |
| Details | RIBOSOMAL_S15 Ribosomal protein S15 signature. LseHLkvhKkDhhShrgLlmMvgqrrrLlrY |
| Chain | Residue | Details |
| Ao | LEU38-TYR68 |
| site_id | PS00700 |
| Number of Residues | 22 |
| Details | RIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QattVknKdiRkFlDGIYVseK |
| Chain | Residue | Details |
| Be | GLN163-LYS184 |
| site_id | PS00467 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_L2 Ribosomal protein L2 signature. PrvRGVAmNPvE |
| Chain | Residue | Details |
| Ba | PRO197-GLU208 |
| site_id | PS00360 |
| Number of Residues | 19 |
| Details | RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGhvAQiyAirqSiSKAL |
| Chain | Residue | Details |
| Ai | GLY74-LEU92 |
| site_id | PS00359 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_L11 Ribosomal protein L11 signature. KeIlGTaqSVGcNVdG |
| Chain | Residue | Details |
| Bi | LYS130-GLY145 |
| site_id | PS01257 |
| Number of Residues | 22 |
| Details | RIBOSOMAL_L10E Ribosomal protein L10e signature. ADRlqtGMRgAFGKPqGtvAKV |
| Chain | Residue | Details |
| Bh | ALA107-VAL128 |
| site_id | PS00051 |
| Number of Residues | 17 |
| Details | RIBOSOMAL_L39E Ribosomal protein L39e signature. KTgnkIryNskrRHWRR |
| Chain | Residue | Details |
| B3 | LYS30-ARG46 |
| site_id | PS01077 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_L37E Ribosomal protein L37e signature. GTsSfGkRrnkt.HtlCrRCG |
| Chain | Residue | Details |
| B2 | GLY4-GLY23 |
| site_id | PS00579 |
| Number of Residues | 15 |
| Details | RIBOSOMAL_L29 Ribosomal protein L29 signature. KLSKIRvVRKSIARV |
| Chain | Residue | Details |
| Bv | LYS43-VAL57 |
| site_id | PS00580 |
| Number of Residues | 21 |
| Details | RIBOSOMAL_L32E Ribosomal protein L32e signature. FiRhqsdRyvKIkrn..WRKprG |
| Chain | Residue | Details |
| By | PHE20-GLY40 |
| site_id | PS00055 |
| Number of Residues | 8 |
| Details | RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR |
| Chain | Residue | Details |
| Al | LYS60-ARG67 |
| site_id | PS00054 |
| Number of Residues | 23 |
| Details | RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GMkIgrieDvTPiPSD |
| Chain | Residue | Details |
| Ak | LEU116-ASP138 |
| site_id | PS01082 |
| Number of Residues | 18 |
| Details | RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CrkmgVPYciIkGKarLG |
| Chain | Residue | Details |
| Bf | CYS174-GLY191 |
| site_id | PS01172 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_L44E Ribosomal protein L44e signature. KtTKKivLRleC |
| Chain | Residue | Details |
| B4 | LYS61-CYS72 |
| site_id | PS00962 |
| Number of Residues | 12 |
| Details | RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. VlKFLAAGTHLG |
| Chain | Residue | Details |
| Ab | VAL14-GLY25 |
| site_id | PS00963 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlLVVtDpraDhqpLtEasyvNLP |
| Chain | Residue | Details |
| Ab | PRO118-PRO142 |
| site_id | PS00548 |
| Number of Residues | 37 |
| Details | RIBOSOMAL_S3 Ribosomal protein S3 signature. AKsmkfvdGlMihSgdpVnyyVDtavrhvlLrqGvlG |
| Chain | Residue | Details |
| Ac | ALA147-GLY183 |
| site_id | PS00050 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVRLApdydaldV |
| Chain | Residue | Details |
| Bs | LYS134-VAL149 |
| site_id | PS01199 |
| Number of Residues | 20 |
| Details | RIBOSOMAL_L1 Ribosomal protein L1 signature. MqdIgryLGtvLGPRGkMPE |
| Chain | Residue | Details |
| B5 | MET111-GLU130 |
| site_id | PS00358 |
| Number of Residues | 17 |
| Details | RIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLTGQtpVfSkARyT |
| Chain | Residue | Details |
| Bd | LEU40-THR56 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. ALSGswDgTLRLWDL |
| Chain | Residue | Details |
| Aa | ALA78-LEU92 | |
| Aa | ILE120-THR134 | |
| Aa | ILE165-LEU179 | |
| Aa | CYS207-LEU221 |
