Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4V59

Crystal structure of fatty acid synthase complexed with nadp+ from thermomyces lanuginosus at 3.1 angstrom resolution.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004312	molecular_function	fatty acid synthase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0005835	cellular_component	fatty acid synthase complex
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0016746	molecular_function	acyltransferase activity
A	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016746	molecular_function	acyltransferase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004312	molecular_function	fatty acid synthase activity
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0005835	cellular_component	fatty acid synthase complex
C	0006633	biological_process	fatty acid biosynthetic process
C	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
C	0016746	molecular_function	acyltransferase activity
C	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004312	molecular_function	fatty acid synthase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0005835	cellular_component	fatty acid synthase complex
D	0006633	biological_process	fatty acid biosynthetic process
D	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
D	0016746	molecular_function	acyltransferase activity
D	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0004312	molecular_function	fatty acid synthase activity
E	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
E	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
E	0005835	cellular_component	fatty acid synthase complex
E	0006633	biological_process	fatty acid biosynthetic process
E	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
E	0016746	molecular_function	acyltransferase activity
E	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0004312	molecular_function	fatty acid synthase activity
F	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
F	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F	0005835	cellular_component	fatty acid synthase complex
F	0006633	biological_process	fatty acid biosynthetic process
F	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
F	0016746	molecular_function	acyltransferase activity
F	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0004312	molecular_function	fatty acid synthase activity
G	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
G	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
G	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0005835	cellular_component	fatty acid synthase complex
G	0006633	biological_process	fatty acid biosynthetic process
G	0016740	molecular_function	transferase activity
H	0004312	molecular_function	fatty acid synthase activity
H	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
H	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
H	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
H	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H	0005835	cellular_component	fatty acid synthase complex
H	0006633	biological_process	fatty acid biosynthetic process
H	0016740	molecular_function	transferase activity
I	0004312	molecular_function	fatty acid synthase activity
I	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
I	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
I	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0005835	cellular_component	fatty acid synthase complex
I	0006633	biological_process	fatty acid biosynthetic process
I	0016740	molecular_function	transferase activity
J	0004312	molecular_function	fatty acid synthase activity
J	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
J	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
J	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
J	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J	0005835	cellular_component	fatty acid synthase complex
J	0006633	biological_process	fatty acid biosynthetic process
J	0016740	molecular_function	transferase activity
K	0004312	molecular_function	fatty acid synthase activity
K	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
K	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
K	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
K	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K	0005835	cellular_component	fatty acid synthase complex
K	0006633	biological_process	fatty acid biosynthetic process
K	0016740	molecular_function	transferase activity
L	0004312	molecular_function	fatty acid synthase activity
L	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
L	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
L	0004317	molecular_function	(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
L	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L	0005835	cellular_component	fatty acid synthase complex
L	0006633	biological_process	fatty acid biosynthetic process
L	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue NAP A 1901

Chain	Residue
A	GLY659
A	ALA748
A	PRO800
A	TYR814
A	LYS818
A	ILE844
A	THR847
A	LEU852
A	GLY661
A	ILE665
A	THR684
A	SER685
A	ARG686
A	ASN715
A	GLN716
A	PHE746

site_id	AC2
Number of Residues	15
Details	binding site for residue NAP B 1901

Chain	Residue
B	GLY659
B	GLY661
B	ILE665
B	THR684
B	SER685
B	ARG686
B	ASN715
B	GLN716
B	PHE746
B	ALA748
B	PRO800
B	TYR814
B	LYS818
B	ILE844
B	LEU852

site_id	AC3
Number of Residues	13
Details	binding site for residue NAP C 1901

Chain	Residue
C	GLY659
C	GLY661
C	ILE665
C	THR684
C	SER685
C	ARG686
C	ASN715
C	GLN716
C	PHE746
C	ALA748
C	TYR814
C	LYS818
C	LEU852

site_id	AC4
Number of Residues	15
Details	binding site for residue NAP D 1901

Chain	Residue
D	GLY659
D	GLY661
D	ILE665
D	THR684
D	SER685
D	ARG686
D	ASN715
D	GLN716
D	PHE746
D	ALA748
D	PRO800
D	TYR814
D	LYS818
D	ILE844
D	LEU852

site_id	AC5
Number of Residues	14
Details	binding site for residue NAP E 1901

Chain	Residue
E	GLY659
E	GLY661
E	ILE665
E	THR684
E	SER685
E	ARG686
E	ASN715
E	GLN716
E	PHE746
E	ALA748
E	PRO800
E	TYR814
E	LYS818
E	LEU852

site_id	AC6
Number of Residues	14
Details	binding site for residue NAP F 1901

Chain	Residue
F	GLY659
F	GLY661
F	ILE665
F	THR684
F	SER685
F	ARG686
F	ASN715
F	GLN716
F	PHE746
F	ALA748
F	TYR814
F	LYS818
F	ILE844
F	LEU852

site_id	AC7
Number of Residues	18
Details	binding site for residue FMN G 2101

Chain	Residue
G	GLY813
G	SER814
G	MET817
G	LEU1067
G	ALA1072
G	NAP2102
G	GLY607
G	MET608
G	THR609
G	PRO610
G	ASN661
G	GLY693
G	LYS717
G	THR744
G	ARG747
G	GLY749
G	SER780
G	GLY781

site_id	AC8
Number of Residues	15
Details	binding site for residue NAP G 2102

Chain	Residue
G	THR609
G	GLY633
G	TYR636
G	ILE663
G	ARG668
G	GLY749
G	HIS751
G	GLU863
G	ASP952
G	LYS1026
G	PRO1027
G	LYS1044
G	ASP1045
G	LEU1047
G	FMN2101

site_id	AC9
Number of Residues	17
Details	binding site for residue FMN H 2101

Chain	Residue
H	GLY607
H	MET608
H	THR609
H	PRO610
H	ASN661
H	GLY693
H	LYS717
H	THR744
H	ARG747
H	GLY749
H	SER780
H	GLY781
H	GLY813
H	SER814
H	LEU1067
H	ALA1072
H	NAP2102

site_id	AD1
Number of Residues	15
Details	binding site for residue NAP H 2102

Chain	Residue
H	THR609
H	GLY633
H	TYR636
H	ILE663
H	ARG668
H	GLY749
H	HIS751
H	GLU863
H	ASP952
H	LYS1026
H	PRO1027
H	LYS1044
H	ASP1045
H	LEU1047
H	FMN2101

site_id	AD2
Number of Residues	17
Details	binding site for residue FMN I 2101

Chain	Residue
I	GLY607
I	MET608
I	THR609
I	PRO610
I	ASN661
I	GLY693
I	LYS717
I	THR744
I	ARG747
I	GLY749
I	SER780
I	GLY781
I	GLY813
I	SER814
I	LEU1067
I	ALA1072
I	NAP2102

site_id	AD3
Number of Residues	16
Details	binding site for residue NAP I 2102

Chain	Residue
I	THR609
I	GLY633
I	TYR636
I	ILE663
I	ASN666
I	ARG668
I	GLY749
I	HIS751
I	GLU863
I	ASP952
I	LYS1026
I	PRO1027
I	LYS1044
I	ASP1045
I	LEU1047
I	FMN2101

site_id	AD4
Number of Residues	17
Details	binding site for residue FMN J 2101

Chain	Residue
J	GLY607
J	MET608
J	THR609
J	PRO610
J	ASN661
J	GLY693
J	LYS717
J	THR744
J	ARG747
J	GLY749
J	SER780
J	GLY781
J	GLY813
J	SER814
J	LEU1067
J	ALA1072
J	NAP2102

site_id	AD5
Number of Residues	16
Details	binding site for residue NAP J 2102

Chain	Residue
J	THR609
J	GLY633
J	TYR636
J	ILE663
J	ASN666
J	ARG668
J	GLY749
J	HIS751
J	GLU863
J	ASP952
J	LYS1026
J	PRO1027
J	LYS1044
J	ASP1045
J	LEU1047
J	FMN2101

site_id	AD6
Number of Residues	18
Details	binding site for residue FMN K 2101

Chain	Residue
K	GLY607
K	MET608
K	THR609
K	PRO610
K	ASN661
K	GLY693
K	LYS717
K	THR744
K	ARG747
K	GLY749
K	SER780
K	GLY781
K	GLY813
K	SER814
K	MET817
K	LEU1067
K	ALA1072
K	NAP2102

site_id	AD7
Number of Residues	16
Details	binding site for residue NAP K 2102

Chain	Residue
K	THR609
K	GLY633
K	TYR636
K	ILE663
K	ASN666
K	ARG668
K	GLY749
K	HIS751
K	GLU863
K	ASP952
K	LYS1026
K	PRO1027
K	LYS1044
K	ASP1045
K	LEU1047
K	FMN2101

site_id	AD8
Number of Residues	17
Details	binding site for residue FMN L 2101

Chain	Residue
L	GLY607
L	MET608
L	THR609
L	PRO610
L	ASN661
L	GLY693
L	LYS717
L	THR744
L	ARG747
L	GLY749
L	SER780
L	GLY781
L	GLY813
L	SER814
L	LEU1067
L	ALA1072
L	NAP2102

site_id	AD9
Number of Residues	15
Details	binding site for residue NAP L 2102

Chain	Residue
L	THR609
L	GLY633
L	TYR636
L	ILE663
L	ARG668
L	GLY749
L	HIS751
L	GLU863
L	ASP952
L	LYS1026
L	PRO1027
L	LYS1044
L	ASP1045
L	LEU1047
L	FMN2101

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTLQNEILGDL

Chain	Residue	Details
A	LEU175-LEU190

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATAveSL

Chain	Residue	Details
A	GLY1271-LEU1287

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)