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4V59

Crystal structure of fatty acid synthase complexed with nadp+ from thermomyces lanuginosus at 3.1 angstrom resolution.

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004312molecular_functionfatty acid synthase activity
A0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
A0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A0005835cellular_componentfatty acid synthase complex
A0006633biological_processfatty acid biosynthetic process
A0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
A0016746molecular_functionacyltransferase activity
A0042759biological_processlong-chain fatty acid biosynthetic process
B0000287molecular_functionmagnesium ion binding
B0004312molecular_functionfatty acid synthase activity
B0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
B0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B0005835cellular_componentfatty acid synthase complex
B0006633biological_processfatty acid biosynthetic process
B0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
B0016746molecular_functionacyltransferase activity
B0042759biological_processlong-chain fatty acid biosynthetic process
C0000287molecular_functionmagnesium ion binding
C0004312molecular_functionfatty acid synthase activity
C0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
C0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C0005835cellular_componentfatty acid synthase complex
C0006633biological_processfatty acid biosynthetic process
C0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
C0016746molecular_functionacyltransferase activity
C0042759biological_processlong-chain fatty acid biosynthetic process
D0000287molecular_functionmagnesium ion binding
D0004312molecular_functionfatty acid synthase activity
D0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
D0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D0005835cellular_componentfatty acid synthase complex
D0006633biological_processfatty acid biosynthetic process
D0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
D0016746molecular_functionacyltransferase activity
D0042759biological_processlong-chain fatty acid biosynthetic process
E0000287molecular_functionmagnesium ion binding
E0004312molecular_functionfatty acid synthase activity
E0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
E0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
E0005835cellular_componentfatty acid synthase complex
E0006633biological_processfatty acid biosynthetic process
E0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
E0016746molecular_functionacyltransferase activity
E0042759biological_processlong-chain fatty acid biosynthetic process
F0000287molecular_functionmagnesium ion binding
F0004312molecular_functionfatty acid synthase activity
F0004315molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity
F0004316molecular_function3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F0005835cellular_componentfatty acid synthase complex
F0006633biological_processfatty acid biosynthetic process
F0008897molecular_functionholo-[acyl-carrier-protein] synthase activity
F0016746molecular_functionacyltransferase activity
F0042759biological_processlong-chain fatty acid biosynthetic process
G0004312molecular_functionfatty acid synthase activity
G0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
G0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
G0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
G0005835cellular_componentfatty acid synthase complex
G0006633biological_processfatty acid biosynthetic process
G0016740molecular_functiontransferase activity
G0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H0004312molecular_functionfatty acid synthase activity
H0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
H0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
H0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
H0005835cellular_componentfatty acid synthase complex
H0006633biological_processfatty acid biosynthetic process
H0016740molecular_functiontransferase activity
H0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I0004312molecular_functionfatty acid synthase activity
I0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
I0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
I0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
I0005835cellular_componentfatty acid synthase complex
I0006633biological_processfatty acid biosynthetic process
I0016740molecular_functiontransferase activity
I0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
J0004312molecular_functionfatty acid synthase activity
J0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
J0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
J0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
J0005835cellular_componentfatty acid synthase complex
J0006633biological_processfatty acid biosynthetic process
J0016740molecular_functiontransferase activity
J0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
K0004312molecular_functionfatty acid synthase activity
K0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
K0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
K0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
K0005835cellular_componentfatty acid synthase complex
K0006633biological_processfatty acid biosynthetic process
K0016740molecular_functiontransferase activity
K0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
L0004312molecular_functionfatty acid synthase activity
L0004313molecular_function[acyl-carrier-protein] S-acetyltransferase activity
L0004314molecular_function[acyl-carrier-protein] S-malonyltransferase activity
L0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
L0005835cellular_componentfatty acid synthase complex
L0006633biological_processfatty acid biosynthetic process
L0016740molecular_functiontransferase activity
L0019171molecular_function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue NAP A 1901
ChainResidue
AGLY659
AALA748
APRO800
ATYR814
ALYS818
AILE844
ATHR847
ALEU852
AGLY661
AILE665
ATHR684
ASER685
AARG686
AASN715
AGLN716
APHE746

site_idAC2
Number of Residues15
Detailsbinding site for residue NAP B 1901
ChainResidue
BGLY659
BGLY661
BILE665
BTHR684
BSER685
BARG686
BASN715
BGLN716
BPHE746
BALA748
BPRO800
BTYR814
BLYS818
BILE844
BLEU852

site_idAC3
Number of Residues13
Detailsbinding site for residue NAP C 1901
ChainResidue
CGLY659
CGLY661
CILE665
CTHR684
CSER685
CARG686
CASN715
CGLN716
CPHE746
CALA748
CTYR814
CLYS818
CLEU852

site_idAC4
Number of Residues15
Detailsbinding site for residue NAP D 1901
ChainResidue
DGLY659
DGLY661
DILE665
DTHR684
DSER685
DARG686
DASN715
DGLN716
DPHE746
DALA748
DPRO800
DTYR814
DLYS818
DILE844
DLEU852

site_idAC5
Number of Residues14
Detailsbinding site for residue NAP E 1901
ChainResidue
EGLY659
EGLY661
EILE665
ETHR684
ESER685
EARG686
EASN715
EGLN716
EPHE746
EALA748
EPRO800
ETYR814
ELYS818
ELEU852

site_idAC6
Number of Residues14
Detailsbinding site for residue NAP F 1901
ChainResidue
FGLY659
FGLY661
FILE665
FTHR684
FSER685
FARG686
FASN715
FGLN716
FPHE746
FALA748
FTYR814
FLYS818
FILE844
FLEU852

site_idAC7
Number of Residues18
Detailsbinding site for residue FMN G 2101
ChainResidue
GGLY813
GSER814
GMET817
GLEU1067
GALA1072
GNAP2102
GGLY607
GMET608
GTHR609
GPRO610
GASN661
GGLY693
GLYS717
GTHR744
GARG747
GGLY749
GSER780
GGLY781

site_idAC8
Number of Residues15
Detailsbinding site for residue NAP G 2102
ChainResidue
GTHR609
GGLY633
GTYR636
GILE663
GARG668
GGLY749
GHIS751
GGLU863
GASP952
GLYS1026
GPRO1027
GLYS1044
GASP1045
GLEU1047
GFMN2101

site_idAC9
Number of Residues17
Detailsbinding site for residue FMN H 2101
ChainResidue
HGLY607
HMET608
HTHR609
HPRO610
HASN661
HGLY693
HLYS717
HTHR744
HARG747
HGLY749
HSER780
HGLY781
HGLY813
HSER814
HLEU1067
HALA1072
HNAP2102

site_idAD1
Number of Residues15
Detailsbinding site for residue NAP H 2102
ChainResidue
HTHR609
HGLY633
HTYR636
HILE663
HARG668
HGLY749
HHIS751
HGLU863
HASP952
HLYS1026
HPRO1027
HLYS1044
HASP1045
HLEU1047
HFMN2101

site_idAD2
Number of Residues17
Detailsbinding site for residue FMN I 2101
ChainResidue
IGLY607
IMET608
ITHR609
IPRO610
IASN661
IGLY693
ILYS717
ITHR744
IARG747
IGLY749
ISER780
IGLY781
IGLY813
ISER814
ILEU1067
IALA1072
INAP2102

site_idAD3
Number of Residues16
Detailsbinding site for residue NAP I 2102
ChainResidue
ITHR609
IGLY633
ITYR636
IILE663
IASN666
IARG668
IGLY749
IHIS751
IGLU863
IASP952
ILYS1026
IPRO1027
ILYS1044
IASP1045
ILEU1047
IFMN2101

site_idAD4
Number of Residues17
Detailsbinding site for residue FMN J 2101
ChainResidue
JGLY607
JMET608
JTHR609
JPRO610
JASN661
JGLY693
JLYS717
JTHR744
JARG747
JGLY749
JSER780
JGLY781
JGLY813
JSER814
JLEU1067
JALA1072
JNAP2102

site_idAD5
Number of Residues16
Detailsbinding site for residue NAP J 2102
ChainResidue
JTHR609
JGLY633
JTYR636
JILE663
JASN666
JARG668
JGLY749
JHIS751
JGLU863
JASP952
JLYS1026
JPRO1027
JLYS1044
JASP1045
JLEU1047
JFMN2101

site_idAD6
Number of Residues18
Detailsbinding site for residue FMN K 2101
ChainResidue
KGLY607
KMET608
KTHR609
KPRO610
KASN661
KGLY693
KLYS717
KTHR744
KARG747
KGLY749
KSER780
KGLY781
KGLY813
KSER814
KMET817
KLEU1067
KALA1072
KNAP2102

site_idAD7
Number of Residues16
Detailsbinding site for residue NAP K 2102
ChainResidue
KTHR609
KGLY633
KTYR636
KILE663
KASN666
KARG668
KGLY749
KHIS751
KGLU863
KASP952
KLYS1026
KPRO1027
KLYS1044
KASP1045
KLEU1047
KFMN2101

site_idAD8
Number of Residues17
Detailsbinding site for residue FMN L 2101
ChainResidue
LGLY607
LMET608
LTHR609
LPRO610
LASN661
LGLY693
LLYS717
LTHR744
LARG747
LGLY749
LSER780
LGLY781
LGLY813
LSER814
LLEU1067
LALA1072
LNAP2102

site_idAD9
Number of Residues15
Detailsbinding site for residue NAP L 2102
ChainResidue
LTHR609
LGLY633
LTYR636
LILE663
LARG668
LGLY749
LHIS751
LGLU863
LASP952
LLYS1026
LPRO1027
LLYS1044
LASP1045
LLEU1047
LFMN2101

Functional Information from PROSITE/UniProt
site_idPS00012
Number of Residues16
DetailsPHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTLQNEILGDL
ChainResidueDetails
ALEU175-LEU190

site_idPS00606
Number of Residues17
DetailsKS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATAveSL
ChainResidueDetails
AGLY1271-LEU1287

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PDB entries from 2024-11-06

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