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4V4B

Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AB0003735molecular_functionstructural constituent of ribosome
AB0005840cellular_componentribosome
AB0006412biological_processtranslation
AB0015935cellular_componentsmall ribosomal subunit
AC0003723molecular_functionRNA binding
AC0003735molecular_functionstructural constituent of ribosome
AC0006412biological_processtranslation
AC0015935cellular_componentsmall ribosomal subunit
AD0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AD0003723molecular_functionRNA binding
AD0003735molecular_functionstructural constituent of ribosome
AD0005515molecular_functionprotein binding
AD0005634cellular_componentnucleus
AD0005654cellular_componentnucleoplasm
AD0005730cellular_componentnucleolus
AD0005737cellular_componentcytoplasm
AD0005829cellular_componentcytosol
AD0005840cellular_componentribosome
AD0006364biological_processrRNA processing
AD0006412biological_processtranslation
AD0015935cellular_componentsmall ribosomal subunit
AD0019843molecular_functionrRNA binding
AD0022627cellular_componentcytosolic small ribosomal subunit
AD0030686cellular_component90S preribosome
AD0032040cellular_componentsmall-subunit processome
AD0042254biological_processribosome biogenesis
AD0042274biological_processribosomal small subunit biogenesis
AD0043226cellular_componentorganelle
AD1990904cellular_componentribonucleoprotein complex
AE0003723molecular_functionRNA binding
AE0003735molecular_functionstructural constituent of ribosome
AE0005840cellular_componentribosome
AE0006412biological_processtranslation
AE0015935cellular_componentsmall ribosomal subunit
AG0003723molecular_functionRNA binding
AG0003735molecular_functionstructural constituent of ribosome
AG0006412biological_processtranslation
AG0015935cellular_componentsmall ribosomal subunit
AH0003735molecular_functionstructural constituent of ribosome
AH0005840cellular_componentribosome
AH0006412biological_processtranslation
AI0003735molecular_functionstructural constituent of ribosome
AI0005840cellular_componentribosome
AI0006412biological_processtranslation
AJ0003723molecular_functionRNA binding
AJ0003735molecular_functionstructural constituent of ribosome
AJ0005840cellular_componentribosome
AJ0006412biological_processtranslation
AJ0015935cellular_componentsmall ribosomal subunit
AK0000028biological_processribosomal small subunit assembly
AK0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AK0002181biological_processcytoplasmic translation
AK0003729molecular_functionmRNA binding
AK0003735molecular_functionstructural constituent of ribosome
AK0005634cellular_componentnucleus
AK0005654cellular_componentnucleoplasm
AK0005730cellular_componentnucleolus
AK0005737cellular_componentcytoplasm
AK0005829cellular_componentcytosol
AK0005840cellular_componentribosome
AK0006364biological_processrRNA processing
AK0006412biological_processtranslation
AK0022627cellular_componentcytosolic small ribosomal subunit
AK0030686cellular_component90S preribosome
AK0032040cellular_componentsmall-subunit processome
AK0042254biological_processribosome biogenesis
AK1990904cellular_componentribonucleoprotein complex
AL0003735molecular_functionstructural constituent of ribosome
AL0005840cellular_componentribosome
AL0006412biological_processtranslation
AL0015935cellular_componentsmall ribosomal subunit
AM0003676molecular_functionnucleic acid binding
AM0003723molecular_functionRNA binding
AM0003735molecular_functionstructural constituent of ribosome
AM0005840cellular_componentribosome
AM0006412biological_processtranslation
AN0003735molecular_functionstructural constituent of ribosome
AN0005840cellular_componentribosome
AN0006412biological_processtranslation
AN0008270molecular_functionzinc ion binding
AO0003735molecular_functionstructural constituent of ribosome
AO0005840cellular_componentribosome
AO0006412biological_processtranslation
AQ0003735molecular_functionstructural constituent of ribosome
AQ0005840cellular_componentribosome
AQ0006412biological_processtranslation
AS0003723molecular_functionRNA binding
AS0003735molecular_functionstructural constituent of ribosome
AS0005840cellular_componentribosome
AS0006412biological_processtranslation
AT0003746molecular_functiontranslation elongation factor activity
AT0003924molecular_functionGTPase activity
AT0005515molecular_functionprotein binding
AT0005525molecular_functionGTP binding
AT0005737cellular_componentcytoplasm
AT0005829cellular_componentcytosol
AT0006412biological_processtranslation
AT0006414biological_processtranslational elongation
AT0016787molecular_functionhydrolase activity
AT0019843molecular_functionrRNA binding
AT0042802molecular_functionidentical protein binding
AT0043022molecular_functionribosome binding
AT0045901biological_processpositive regulation of translational elongation
AT0051087molecular_functionprotein-folding chaperone binding
AT1990145biological_processmaintenance of translational fidelity
AT1990904cellular_componentribonucleoprotein complex
B00002181biological_processcytoplasmic translation
B00003735molecular_functionstructural constituent of ribosome
B00005737cellular_componentcytoplasm
B00005829cellular_componentcytosol
B00005840cellular_componentribosome
B00006412biological_processtranslation
B00022625cellular_componentcytosolic large ribosomal subunit
B01990904cellular_componentribonucleoprotein complex
B90003735molecular_functionstructural constituent of ribosome
B90005840cellular_componentribosome
B90006412biological_processtranslation
BA0003723molecular_functionRNA binding
BA0003735molecular_functionstructural constituent of ribosome
BA0006412biological_processtranslation
BA0015934cellular_componentlarge ribosomal subunit
BB0003735molecular_functionstructural constituent of ribosome
BB0005840cellular_componentribosome
BB0006412biological_processtranslation
BC0000027biological_processribosomal large subunit assembly
BC0002181biological_processcytoplasmic translation
BC0003723molecular_functionRNA binding
BC0003735molecular_functionstructural constituent of ribosome
BC0005515molecular_functionprotein binding
BC0005737cellular_componentcytoplasm
BC0005829cellular_componentcytosol
BC0005840cellular_componentribosome
BC0006364biological_processrRNA processing
BC0006412biological_processtranslation
BC0006414biological_processtranslational elongation
BC0022625cellular_componentcytosolic large ribosomal subunit
BC1990145biological_processmaintenance of translational fidelity
BC1990904cellular_componentribonucleoprotein complex
BD0002181biological_processcytoplasmic translation
BD0003723molecular_functionRNA binding
BD0003735molecular_functionstructural constituent of ribosome
BD0005634cellular_componentnucleus
BD0005737cellular_componentcytoplasm
BD0005829cellular_componentcytosol
BD0005840cellular_componentribosome
BD0006412biological_processtranslation
BD0022625cellular_componentcytosolic large ribosomal subunit
BD1990904cellular_componentribonucleoprotein complex
BE0003735molecular_functionstructural constituent of ribosome
BE0005840cellular_componentribosome
BE0006412biological_processtranslation
BE0008097molecular_function5S rRNA binding
BF0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BF0003723molecular_functionRNA binding
BF0003735molecular_functionstructural constituent of ribosome
BG0042254biological_processribosome biogenesis
BG1990904cellular_componentribonucleoprotein complex
BH0002181biological_processcytoplasmic translation
BH0003735molecular_functionstructural constituent of ribosome
BH0005737cellular_componentcytoplasm
BH0005829cellular_componentcytosol
BH0005840cellular_componentribosome
BH0006412biological_processtranslation
BH0019843molecular_functionrRNA binding
BH0022625cellular_componentcytosolic large ribosomal subunit
BH1990904cellular_componentribonucleoprotein complex
BI0003735molecular_functionstructural constituent of ribosome
BI0005840cellular_componentribosome
BI0006412biological_processtranslation
BJ0003735molecular_functionstructural constituent of ribosome
BJ0005840cellular_componentribosome
BJ0006412biological_processtranslation
BK0003735molecular_functionstructural constituent of ribosome
BK0005840cellular_componentribosome
BK0006412biological_processtranslation
BL0002181biological_processcytoplasmic translation
BL0003723molecular_functionRNA binding
BL0003735molecular_functionstructural constituent of ribosome
BL0005737cellular_componentcytoplasm
BL0005829cellular_componentcytosol
BL0005840cellular_componentribosome
BL0006412biological_processtranslation
BL0022625cellular_componentcytosolic large ribosomal subunit
BL0022626cellular_componentcytosolic ribosome
BL1990904cellular_componentribonucleoprotein complex
BM0003735molecular_functionstructural constituent of ribosome
BM0005840cellular_componentribosome
BM0006412biological_processtranslation
BM0015934cellular_componentlarge ribosomal subunit
BN0000448biological_processcleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BN0002181biological_processcytoplasmic translation
BN0003735molecular_functionstructural constituent of ribosome
BN0005737cellular_componentcytoplasm
BN0005829cellular_componentcytosol
BN0005840cellular_componentribosome
BN0006412biological_processtranslation
BN0015934cellular_componentlarge ribosomal subunit
BN0022625cellular_componentcytosolic large ribosomal subunit
BN0030687cellular_componentpreribosome, large subunit precursor
BN1990904cellular_componentribonucleoprotein complex
BO0003735molecular_functionstructural constituent of ribosome
BO0005840cellular_componentribosome
BO0006412biological_processtranslation
BP0003723molecular_functionRNA binding
BP0003735molecular_functionstructural constituent of ribosome
BP0005840cellular_componentribosome
BP0006412biological_processtranslation
BP0022625cellular_componentcytosolic large ribosomal subunit
BQ0003735molecular_functionstructural constituent of ribosome
BQ0005840cellular_componentribosome
BQ0006412biological_processtranslation
BR0003735molecular_functionstructural constituent of ribosome
BR0005840cellular_componentribosome
BR0006412biological_processtranslation
BT0003735molecular_functionstructural constituent of ribosome
BT0005840cellular_componentribosome
BT0006412biological_processtranslation
BT0019843molecular_functionrRNA binding
BU0002181biological_processcytoplasmic translation
BU0003723molecular_functionRNA binding
BU0003735molecular_functionstructural constituent of ribosome
BU0005737cellular_componentcytoplasm
BU0005829cellular_componentcytosol
BU0005840cellular_componentribosome
BU0006412biological_processtranslation
BU0015934cellular_componentlarge ribosomal subunit
BU0022625cellular_componentcytosolic large ribosomal subunit
BU0032991cellular_componentprotein-containing complex
BU0042273biological_processribosomal large subunit biogenesis
BU0043229cellular_componentintracellular organelle
BU1990904cellular_componentribonucleoprotein complex
BV0002181biological_processcytoplasmic translation
BV0003723molecular_functionRNA binding
BV0003735molecular_functionstructural constituent of ribosome
BV0005634cellular_componentnucleus
BV0005737cellular_componentcytoplasm
BV0005829cellular_componentcytosol
BV0005840cellular_componentribosome
BV0006412biological_processtranslation
BV0015934cellular_componentlarge ribosomal subunit
BV0022625cellular_componentcytosolic large ribosomal subunit
BV0043232cellular_componentintracellular non-membrane-bounded organelle
BV1990904cellular_componentribonucleoprotein complex
BW0003735molecular_functionstructural constituent of ribosome
BW0005840cellular_componentribosome
BW0006412biological_processtranslation
BX0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BX0003735molecular_functionstructural constituent of ribosome
BX0005840cellular_componentribosome
BX0006412biological_processtranslation
BX0022625cellular_componentcytosolic large ribosomal subunit
BY0000448biological_processcleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BY0002181biological_processcytoplasmic translation
BY0003723molecular_functionRNA binding
BY0003735molecular_functionstructural constituent of ribosome
BY0005737cellular_componentcytoplasm
BY0005829cellular_componentcytosol
BY0005840cellular_componentribosome
BY0006412biological_processtranslation
BY0008270molecular_functionzinc ion binding
BY0019843molecular_functionrRNA binding
BY0022625cellular_componentcytosolic large ribosomal subunit
BY0030687cellular_componentpreribosome, large subunit precursor
BY0044391cellular_componentribosomal subunit
BY0046872molecular_functionmetal ion binding
BY1990904cellular_componentribonucleoprotein complex
BZ0003735molecular_functionstructural constituent of ribosome
BZ0005840cellular_componentribosome
BZ0006412biological_processtranslation
Functional Information from PROSITE/UniProt
site_idPS00049
Number of Residues27
DetailsRIBOSOMAL_L14 Ribosomal protein L14 signature. AIVVrqakswrrr.DGvflyFedNagVI
ChainResidueDetails
BRALA76-ILE102

site_idPS00050
Number of Residues16
DetailsRIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVRLTadydaldI
ChainResidueDetails
BTLYS119-ILE134

site_idPS00052
Number of Residues27
DetailsRIBOSOMAL_S7 Ribosomal protein S7 signature. ErLtnsLMmngrnnGKKlkavrIIkhT
ChainResidueDetails
AGGLU90-THR116

site_idPS00053
Number of Residues18
DetailsRIBOSOMAL_S8 Ribosomal protein S8 signature. GyvILTTSaGIMdheeAR
ChainResidueDetails
AHGLY99-ARG116

site_idPS00054
Number of Residues23
DetailsRIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GLrIgrieDvTPvPSD
ChainResidueDetails
AKLEU101-ASP123

site_idPS00055
Number of Residues8
DetailsRIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR
ChainResidueDetails
ALLYS62-ARG69

site_idPS00056
Number of Residues13
DetailsRIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgQcRPIS
ChainResidueDetails
AQGLY119-SER131

site_idPS00301
Number of Residues16
DetailsG_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DTrkdEQeRGITIksT
ChainResidueDetails
ATASP58-THR73

site_idPS00323
Number of Residues25
DetailsRIBOSOMAL_S19 Ribosomal protein S19 signature. NGKafnqveIrpemLGhyLGEFsiT
ChainResidueDetails
ASASN98-THR122

site_idPS00358
Number of Residues17
DetailsRIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLSGQtpVqSkARyT
ChainResidueDetails
BJLEU36-THR52

site_idPS00360
Number of Residues19
DetailsRIBOSOMAL_S9 Ribosomal protein S9 signature. GGGhvSQvyAirqAiAKGL
ChainResidueDetails
AIGLY70-LEU88

site_idPS00361
Number of Residues16
DetailsRIBOSOMAL_S10 Ribosomal protein S10 signature. AeqhNLvkkGPVrLPT
ChainResidueDetails
AJALA45-THR60

site_idPS00362
Number of Residues31
DetailsRIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdAkfrLilIesrihrLarY
ChainResidueDetails
AOVAL97-TYR127

site_idPS00464
Number of Residues25
DetailsRIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinkyesspSHIELvV
ChainResidueDetails
BNARG125-VAL149

site_idPS00467
Number of Residues12
DetailsRIBOSOMAL_L2 Ribosomal protein L2 signature. PktRGVAmNPvD
ChainResidueDetails
BBPRO196-ASP207

site_idPS00474
Number of Residues24
DetailsRIBOSOMAL_L3 Ribosomal protein L3 signature. FeqnemiDaiAvTkGHGfeGvthR
ChainResidueDetails
BCPHE208-ARG231

site_idPS00475
Number of Residues32
DetailsRIBOSOMAL_L15 Ribosomal protein L15 signature. KILGkGrIpnvp.ViVkarfVSklAeekIraaG
ChainResidueDetails
BVLYS110-GLY141

site_idPS00526
Number of Residues20
DetailsRIBOSOMAL_L19E Ribosomal protein L19e signature. QKRLaAsvvgVGkrkVWLDP
ChainResidueDetails
BPGLN6-PRO25

site_idPS00527
Number of Residues23
DetailsRIBOSOMAL_S14 Ribosomal protein S14 signature. RvCsshtglvrkyd.LNICRqCFR
ChainResidueDetails
ANARG21-ARG43

site_idPS00548
Number of Residues37
DetailsRIBOSOMAL_S3 Ribosomal protein S3 signature. AKamkfadGfLihSgqpVndfIDtatrhvlMrqGvlG
ChainResidueDetails
ACALA146-GLY182

site_idPS00579
Number of Residues15
DetailsRIBOSOMAL_L29 Ribosomal protein L29 signature. SLPKIKtVRKSIACV
ChainResidueDetails
BXSER40-VAL54

site_idPS00580
Number of Residues21
DetailsRIBOSOMAL_L32E Ribosomal protein L32e signature. FkRhhsdRyhRVaen..WRKqkG
ChainResidueDetails
B0PHE17-GLY37

site_idPS00585
Number of Residues33
DetailsRIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAvvVVGDsn.GhVGlGiktak.EVag.AI
ChainResidueDetails
AEGLY92-ILE124

site_idPS00632
Number of Residues25
DetailsRIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtqVYKlglAkSvhhARvLI
ChainResidueDetails
ADLEU105-ILE129

site_idPS00634
Number of Residues33
DetailsRIBOSOMAL_L30 Ribosomal protein L30 signature. VLqlLrLtRinSgTfvkvtkatleLLklIepYV
ChainResidueDetails
BFVAL101-VAL133

site_idPS00646
Number of Residues14
DetailsRIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGiRHfwGlrVRGQ
ChainResidueDetails
AMARG123-GLN136

site_idPS00700
Number of Residues22
DetailsRIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QicrVrnKdiRkFlDGIYVshK
ChainResidueDetails
BHGLN163-LYS184

site_idPS00783
Number of Residues24
DetailsRIBOSOMAL_L13 Ribosomal protein L13 signature. LRGMVShktarGKaalerLkVFeG
ChainResidueDetails
BMLEU83-GLY106

site_idPS00939
Number of Residues27
DetailsRIBOSOMAL_L1E Ribosomal protein L1e signature. NhneKryATaSAIaATAvaslvlaRGH
ChainResidueDetails
BDASN113-HIS139

site_idPS00962
Number of Residues12
DetailsRIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. AqLLLAANTHLG
ChainResidueDetails
ABALA13-GLY24

site_idPS00963
Number of Residues25
DetailsRIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlVIVtDprsDaqaIkEasyvNIP
ChainResidueDetails
ABPRO117-PRO141

site_idPS01073
Number of Residues18
DetailsRIBOSOMAL_L24E Ribosomal protein L24e signature. FsGakIyPGrGtlFvRgD
ChainResidueDetails
BSPHE8-ASP25

site_idPS01077
Number of Residues20
DetailsRIBOSOMAL_L37E Ribosomal protein L37e signature. GTpSfGkRhnks.HtlCnRCG
ChainResidueDetails
BYGLY3-GLY22

site_idPS01082
Number of Residues18
DetailsRIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CkkmgVPYaiVkGKarLG
ChainResidueDetails
BGCYS169-GLY186

site_idPS01106
Number of Residues18
DetailsRIBOSOMAL_L18E Ribosomal protein L18e signature. KaLflSKinRPpVSVsRI
ChainResidueDetails
BOLYS50-ILE67

site_idPS01108
Number of Residues18
DetailsRIBOSOMAL_L24 Ribosomal protein L24 signature. DDeVlVVrGskKGqe.GkI
ChainResidueDetails
BUASP53-ILE70

site_idPS01144
Number of Residues15
DetailsRIBOSOMAL_L31E Ribosomal protein L31e signature. VRLApeLNqAiWkRG
ChainResidueDetails
BWVAL48-GLY62

site_idPS01171
Number of Residues26
DetailsRIBOSOMAL_L21E Ribosomal protein L21e signature. GDiVdikangsiqk.GmpHkfYqGkTG
ChainResidueDetails
BQGLY37-GLY62

site_idPS01172
Number of Residues12
DetailsRIBOSOMAL_L44E Ribosomal protein L44e signature. KtTKKvvLRleC
ChainResidueDetails
BZLYS62-CYS73

site_idPS01194
Number of Residues24
DetailsRIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGFVIYRvRVrRG
ChainResidueDetails
BLASP45-GLY68

site_idPS01199
Number of Residues20
DetailsRIBOSOMAL_L1 Ribosomal protein L1 signature. IkqVprlLGpqLSKAGkFPT
ChainResidueDetails
BAILE117-THR136

site_idPS01257
Number of Residues22
DetailsRIBOSOMAL_L10E Ribosomal protein L10e signature. ADRlqqGMRgAWGKPhGlaARV
ChainResidueDetails
BIALA108-VAL129

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsZN_FING: C4-type
ChainResidueDetails
B9SER39-LYS60
BXSER50
BPGLN91
BBGLN249
AQTHR133
AQVAL141

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358
ChainResidueDetails
B9PHE40
BYGLY22
BYSER34
BYGLY37
AMLYS96

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N5-methylarginine; by RMT2 => ECO:0000269|PubMed:11856739, ECO:0000269|PubMed:18957409
ChainResidueDetails
BKARG67
AIGLN76
BBALA93
BBPRO119
BBTHR145

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
BKLYS130

site_idSWS_FT_FI5
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
BCPRO39
BCTYR136
AIPHE59

site_idSWS_FT_FI6
Number of Residues5
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
ACPHE106
ACGLY132
ACLEU141
ACPHE151

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198
ChainResidueDetails
ATTHR713
ATTHR763

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
ATLYS841

222926

PDB entries from 2024-07-24

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