4V1W

3D structure of horse spleen apoferritin determined by electron cryomicroscopy

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006880	biological_process	intracellular sequestering of iron ion
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0070288	cellular_component	ferritin complex
B	0005506	molecular_function	iron ion binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006880	biological_process	intracellular sequestering of iron ion
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0031410	cellular_component	cytoplasmic vesicle
B	0044754	cellular_component	autolysosome
B	0046872	molecular_function	metal ion binding
B	0070288	cellular_component	ferritin complex
C	0005506	molecular_function	iron ion binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006880	biological_process	intracellular sequestering of iron ion
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0044754	cellular_component	autolysosome
C	0046872	molecular_function	metal ion binding
C	0070288	cellular_component	ferritin complex
D	0005506	molecular_function	iron ion binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006880	biological_process	intracellular sequestering of iron ion
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0031410	cellular_component	cytoplasmic vesicle
D	0044754	cellular_component	autolysosome
D	0046872	molecular_function	metal ion binding
D	0070288	cellular_component	ferritin complex
E	0005506	molecular_function	iron ion binding
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005776	cellular_component	autophagosome
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006880	biological_process	intracellular sequestering of iron ion
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0044754	cellular_component	autolysosome
E	0046872	molecular_function	metal ion binding
E	0070288	cellular_component	ferritin complex
F	0005506	molecular_function	iron ion binding
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005776	cellular_component	autophagosome
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006880	biological_process	intracellular sequestering of iron ion
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0031410	cellular_component	cytoplasmic vesicle
F	0044754	cellular_component	autolysosome
F	0046872	molecular_function	metal ion binding
F	0070288	cellular_component	ferritin complex
G	0005506	molecular_function	iron ion binding
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005776	cellular_component	autophagosome
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006880	biological_process	intracellular sequestering of iron ion
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0031410	cellular_component	cytoplasmic vesicle
G	0044754	cellular_component	autolysosome
G	0046872	molecular_function	metal ion binding
G	0070288	cellular_component	ferritin complex
H	0005506	molecular_function	iron ion binding
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005776	cellular_component	autophagosome
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006880	biological_process	intracellular sequestering of iron ion
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0031410	cellular_component	cytoplasmic vesicle
H	0044754	cellular_component	autolysosome
H	0046872	molecular_function	metal ion binding
H	0070288	cellular_component	ferritin complex
I	0005506	molecular_function	iron ion binding
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005776	cellular_component	autophagosome
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006880	biological_process	intracellular sequestering of iron ion
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0031410	cellular_component	cytoplasmic vesicle
I	0044754	cellular_component	autolysosome
I	0046872	molecular_function	metal ion binding
I	0070288	cellular_component	ferritin complex
J	0005506	molecular_function	iron ion binding
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005776	cellular_component	autophagosome
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006880	biological_process	intracellular sequestering of iron ion
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0031410	cellular_component	cytoplasmic vesicle
J	0044754	cellular_component	autolysosome
J	0046872	molecular_function	metal ion binding
J	0070288	cellular_component	ferritin complex
K	0005506	molecular_function	iron ion binding
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005776	cellular_component	autophagosome
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006880	biological_process	intracellular sequestering of iron ion
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0031410	cellular_component	cytoplasmic vesicle
K	0044754	cellular_component	autolysosome
K	0046872	molecular_function	metal ion binding
K	0070288	cellular_component	ferritin complex
L	0005506	molecular_function	iron ion binding
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005776	cellular_component	autophagosome
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006880	biological_process	intracellular sequestering of iron ion
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0031410	cellular_component	cytoplasmic vesicle
L	0044754	cellular_component	autolysosome
L	0046872	molecular_function	metal ion binding
L	0070288	cellular_component	ferritin complex
M	0005506	molecular_function	iron ion binding
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005776	cellular_component	autophagosome
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006880	biological_process	intracellular sequestering of iron ion
M	0008198	molecular_function	ferrous iron binding
M	0008199	molecular_function	ferric iron binding
M	0031410	cellular_component	cytoplasmic vesicle
M	0044754	cellular_component	autolysosome
M	0046872	molecular_function	metal ion binding
M	0070288	cellular_component	ferritin complex
N	0005506	molecular_function	iron ion binding
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005776	cellular_component	autophagosome
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006880	biological_process	intracellular sequestering of iron ion
N	0008198	molecular_function	ferrous iron binding
N	0008199	molecular_function	ferric iron binding
N	0031410	cellular_component	cytoplasmic vesicle
N	0044754	cellular_component	autolysosome
N	0046872	molecular_function	metal ion binding
N	0070288	cellular_component	ferritin complex
O	0005506	molecular_function	iron ion binding
O	0005737	cellular_component	cytoplasm
O	0005764	cellular_component	lysosome
O	0005776	cellular_component	autophagosome
O	0006826	biological_process	iron ion transport
O	0006879	biological_process	intracellular iron ion homeostasis
O	0006880	biological_process	intracellular sequestering of iron ion
O	0008198	molecular_function	ferrous iron binding
O	0008199	molecular_function	ferric iron binding
O	0031410	cellular_component	cytoplasmic vesicle
O	0044754	cellular_component	autolysosome
O	0046872	molecular_function	metal ion binding
O	0070288	cellular_component	ferritin complex
P	0005506	molecular_function	iron ion binding
P	0005737	cellular_component	cytoplasm
P	0005764	cellular_component	lysosome
P	0005776	cellular_component	autophagosome
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006880	biological_process	intracellular sequestering of iron ion
P	0008198	molecular_function	ferrous iron binding
P	0008199	molecular_function	ferric iron binding
P	0031410	cellular_component	cytoplasmic vesicle
P	0044754	cellular_component	autolysosome
P	0046872	molecular_function	metal ion binding
P	0070288	cellular_component	ferritin complex
Q	0005506	molecular_function	iron ion binding
Q	0005737	cellular_component	cytoplasm
Q	0005764	cellular_component	lysosome
Q	0005776	cellular_component	autophagosome
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0006880	biological_process	intracellular sequestering of iron ion
Q	0008198	molecular_function	ferrous iron binding
Q	0008199	molecular_function	ferric iron binding
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0044754	cellular_component	autolysosome
Q	0046872	molecular_function	metal ion binding
Q	0070288	cellular_component	ferritin complex
R	0005506	molecular_function	iron ion binding
R	0005737	cellular_component	cytoplasm
R	0005764	cellular_component	lysosome
R	0005776	cellular_component	autophagosome
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0006880	biological_process	intracellular sequestering of iron ion
R	0008198	molecular_function	ferrous iron binding
R	0008199	molecular_function	ferric iron binding
R	0031410	cellular_component	cytoplasmic vesicle
R	0044754	cellular_component	autolysosome
R	0046872	molecular_function	metal ion binding
R	0070288	cellular_component	ferritin complex
S	0005506	molecular_function	iron ion binding
S	0005737	cellular_component	cytoplasm
S	0005764	cellular_component	lysosome
S	0005776	cellular_component	autophagosome
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0006880	biological_process	intracellular sequestering of iron ion
S	0008198	molecular_function	ferrous iron binding
S	0008199	molecular_function	ferric iron binding
S	0031410	cellular_component	cytoplasmic vesicle
S	0044754	cellular_component	autolysosome
S	0046872	molecular_function	metal ion binding
S	0070288	cellular_component	ferritin complex
T	0005506	molecular_function	iron ion binding
T	0005737	cellular_component	cytoplasm
T	0005764	cellular_component	lysosome
T	0005776	cellular_component	autophagosome
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0006880	biological_process	intracellular sequestering of iron ion
T	0008198	molecular_function	ferrous iron binding
T	0008199	molecular_function	ferric iron binding
T	0031410	cellular_component	cytoplasmic vesicle
T	0044754	cellular_component	autolysosome
T	0046872	molecular_function	metal ion binding
T	0070288	cellular_component	ferritin complex
U	0005506	molecular_function	iron ion binding
U	0005737	cellular_component	cytoplasm
U	0005764	cellular_component	lysosome
U	0005776	cellular_component	autophagosome
U	0006826	biological_process	iron ion transport
U	0006879	biological_process	intracellular iron ion homeostasis
U	0006880	biological_process	intracellular sequestering of iron ion
U	0008198	molecular_function	ferrous iron binding
U	0008199	molecular_function	ferric iron binding
U	0031410	cellular_component	cytoplasmic vesicle
U	0044754	cellular_component	autolysosome
U	0046872	molecular_function	metal ion binding
U	0070288	cellular_component	ferritin complex
V	0005506	molecular_function	iron ion binding
V	0005737	cellular_component	cytoplasm
V	0005764	cellular_component	lysosome
V	0005776	cellular_component	autophagosome
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006880	biological_process	intracellular sequestering of iron ion
V	0008198	molecular_function	ferrous iron binding
V	0008199	molecular_function	ferric iron binding
V	0031410	cellular_component	cytoplasmic vesicle
V	0044754	cellular_component	autolysosome
V	0046872	molecular_function	metal ion binding
V	0070288	cellular_component	ferritin complex
W	0005506	molecular_function	iron ion binding
W	0005737	cellular_component	cytoplasm
W	0005764	cellular_component	lysosome
W	0005776	cellular_component	autophagosome
W	0006826	biological_process	iron ion transport
W	0006879	biological_process	intracellular iron ion homeostasis
W	0006880	biological_process	intracellular sequestering of iron ion
W	0008198	molecular_function	ferrous iron binding
W	0008199	molecular_function	ferric iron binding
W	0031410	cellular_component	cytoplasmic vesicle
W	0044754	cellular_component	autolysosome
W	0046872	molecular_function	metal ion binding
W	0070288	cellular_component	ferritin complex
X	0005506	molecular_function	iron ion binding
X	0005737	cellular_component	cytoplasm
X	0005764	cellular_component	lysosome
X	0005776	cellular_component	autophagosome
X	0006826	biological_process	iron ion transport
X	0006879	biological_process	intracellular iron ion homeostasis
X	0006880	biological_process	intracellular sequestering of iron ion
X	0008198	molecular_function	ferrous iron binding
X	0008199	molecular_function	ferric iron binding
X	0031410	cellular_component	cytoplasmic vesicle
X	0044754	cellular_component	autolysosome
X	0046872	molecular_function	metal ion binding
X	0070288	cellular_component	ferritin complex

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEshFLdeevklIK

Chain	Residue	Details
A	ASP122-LYS142

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site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EkREgaERLLkmQNqRgGR

Chain	Residue	Details
A	GLU57-ARG75

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00085

Chain	Residue	Details
A	GLU53
B	GLU63
T	GLU63
U	GLU53
U	GLU56
U	GLU57
U	GLU60
U	GLU63
V	GLU53
V	GLU56
V	GLU57
V	GLU60
C	GLU53
V	GLU63
W	GLU53
W	GLU56
W	GLU57
W	GLU60
W	GLU63
X	GLU53
X	GLU56
X	GLU57
X	GLU60
C	GLU56
X	GLU63
C	GLU57
C	GLU60
C	GLU63
D	GLU53
D	GLU56
D	GLU57
D	GLU60
A	GLU56
D	GLU63
E	GLU53
E	GLU56
E	GLU57
E	GLU60
E	GLU63
F	GLU53
F	GLU56
F	GLU57
F	GLU60
A	GLU57
F	GLU63
G	GLU53
G	GLU56
G	GLU57
G	GLU60
G	GLU63
H	GLU53
H	GLU56
H	GLU57
H	GLU60
A	GLU60
H	GLU63
I	GLU53
I	GLU56
I	GLU57
I	GLU60
I	GLU63
J	GLU53
J	GLU56
J	GLU57
J	GLU60
A	GLU63
J	GLU63
K	GLU53
K	GLU56
K	GLU57
K	GLU60
K	GLU63
L	GLU53
L	GLU56
L	GLU57
L	GLU60
B	GLU53
L	GLU63
M	GLU53
M	GLU56
M	GLU57
M	GLU60
M	GLU63
N	GLU53
N	GLU56
N	GLU57
N	GLU60
B	GLU56
N	GLU63
O	GLU53
O	GLU56
O	GLU57
O	GLU60
O	GLU63
P	GLU53
P	GLU56
P	GLU57
P	GLU60
B	GLU57
P	GLU63
Q	GLU53
Q	GLU56
Q	GLU57
Q	GLU60
Q	GLU63
R	GLU53
R	GLU56
R	GLU57
R	GLU60
B	GLU60
R	GLU63
S	GLU53
S	GLU56
S	GLU57
S	GLU60
S	GLU63
T	GLU53
T	GLU56
T	GLU57
T	GLU60

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	MOD_RES: N-acetylserine => ECO:0000269|PubMed:7026284

Chain	Residue	Details
A	SER1
J	SER1
K	SER1
L	SER1
M	SER1
N	SER1
O	SER1
P	SER1
Q	SER1
R	SER1
S	SER1
B	SER1
T	SER1
U	SER1
V	SER1
W	SER1
X	SER1
C	SER1
D	SER1
E	SER1
F	SER1
G	SER1
H	SER1
I	SER1

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