4UYZ

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM II - 2.8A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004629	molecular_function	C-type glycerophospholipase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0030178	biological_process	negative regulation of Wnt signaling pathway
A	0030500	biological_process	regulation of bone mineralization
A	0060348	biological_process	bone development
A	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
A	0140776	molecular_function	protein-containing complex destabilizing activity
A	1990697	biological_process	protein depalmitoleylation
A	1990699	molecular_function	palmitoleyl hydrolase activity
B	0004629	molecular_function	C-type glycerophospholipase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity
B	0030178	biological_process	negative regulation of Wnt signaling pathway
B	0030500	biological_process	regulation of bone mineralization
B	0060348	biological_process	bone development
B	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
B	0140776	molecular_function	protein-containing complex destabilizing activity
B	1990697	biological_process	protein depalmitoleylation
B	1990699	molecular_function	palmitoleyl hydrolase activity
C	0004629	molecular_function	C-type glycerophospholipase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0016298	molecular_function	lipase activity
C	0016787	molecular_function	hydrolase activity
C	0030178	biological_process	negative regulation of Wnt signaling pathway
C	0030500	biological_process	regulation of bone mineralization
C	0060348	biological_process	bone development
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0140776	molecular_function	protein-containing complex destabilizing activity
C	1990697	biological_process	protein depalmitoleylation
C	1990699	molecular_function	palmitoleyl hydrolase activity
D	0004629	molecular_function	C-type glycerophospholipase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0016298	molecular_function	lipase activity
D	0016787	molecular_function	hydrolase activity
D	0030178	biological_process	negative regulation of Wnt signaling pathway
D	0030500	biological_process	regulation of bone mineralization
D	0060348	biological_process	bone development
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0140776	molecular_function	protein-containing complex destabilizing activity
D	1990697	biological_process	protein depalmitoleylation
D	1990699	molecular_function	palmitoleyl hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"25731175","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PDB","id":"4UYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UYW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZ5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZ9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UZQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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