4UY4

1.86 A structure of human Spindlin-4 protein in complex with histone H3K4me3 peptide

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Functional Information from GO Data

ChainGOidnamespacecontents
C0070062cellular_componentextracellular exosome
C0005576cellular_componentextracellular region
C0016020cellular_componentmembrane
C0000228cellular_componentnuclear chromosome
C0000788cellular_componentnuclear nucleosome
C0005654cellular_componentnucleoplasm
C0000786cellular_componentnucleosome
C0005634cellular_componentnucleus
C0032991cellular_componentprotein-containing complex
C0045296molecular_functioncadherin binding
C0031492molecular_functionnucleosomal DNA binding
C0046982molecular_functionprotein heterodimerization activity
C0007596biological_processblood coagulation
C0044267biological_processcellular protein metabolic process
C0006325biological_processchromatin organization
C0000183biological_processchromatin silencing at rDNA
C0006335biological_processDNA replication-dependent nucleosome assembly
C0038111biological_processinterleukin-7-mediated signaling pathway
C0045814biological_processnegative regulation of gene expression, epigenetic
C0006334biological_processnucleosome assembly
C0051290biological_processprotein heterotetramerization
C0060968biological_processregulation of gene silencing
C0060964biological_processregulation of gene silencing by miRNA
C0045652biological_processregulation of megakaryocyte differentiation
C0032200biological_processtelomere organization
D0070062cellular_componentextracellular exosome
D0005576cellular_componentextracellular region
D0016020cellular_componentmembrane
D0000228cellular_componentnuclear chromosome
D0000788cellular_componentnuclear nucleosome
D0005654cellular_componentnucleoplasm
D0000786cellular_componentnucleosome
D0005634cellular_componentnucleus
D0032991cellular_componentprotein-containing complex
D0045296molecular_functioncadherin binding
D0031492molecular_functionnucleosomal DNA binding
D0046982molecular_functionprotein heterodimerization activity
D0007596biological_processblood coagulation
D0044267biological_processcellular protein metabolic process
D0006325biological_processchromatin organization
D0000183biological_processchromatin silencing at rDNA
D0006335biological_processDNA replication-dependent nucleosome assembly
D0038111biological_processinterleukin-7-mediated signaling pathway
D0045814biological_processnegative regulation of gene expression, epigenetic
D0006334biological_processnucleosome assembly
D0051290biological_processprotein heterotetramerization
D0060968biological_processregulation of gene silencing
D0060964biological_processregulation of gene silencing by miRNA
D0045652biological_processregulation of megakaryocyte differentiation
D0032200biological_processtelomere organization
A0005829cellular_componentcytosol
A0005654cellular_componentnucleoplasm
A0035064molecular_functionmethylated histone binding
A0007276biological_processgamete generation
B0005829cellular_componentcytosol
B0005654cellular_componentnucleoplasm
B0035064molecular_functionmethylated histone binding
B0007276biological_processgamete generation
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC16BINDING SITE FOR RESIDUE GOL A 1237
ChainResidue
AGLU65
AVAL67
ATYR149
AILE210
AHIS211
APHE221

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
GOL_4uy4_A_123710GLYCEROL binding site
ChainResidueligand
AGLU65GOL: GLYCEROL
AVAL67GOL: GLYCEROL
AILE75GOL: GLYCEROL
APRO142GOL: GLYCEROL
ATYR149GOL: GLYCEROL
ALEU158GOL: GLYCEROL
AILE210-HIS211GOL: GLYCEROL
APHE221GOL: GLYCEROL
AILE230GOL: GLYCEROL

M3L_4uy4_C_411N-TRIMETHYLLYSINE binding site
ChainResidueligand
APHE127-GLU128M3L: N-TRIMETHYLLYSINE
ATRP133M3L: N-TRIMETHYLLYSINE
ATYR152M3L: N-TRIMETHYLLYSINE
AASP155M3L: N-TRIMETHYLLYSINE
ATYR159M3L: N-TRIMETHYLLYSINE
ATYR161M3L: N-TRIMETHYLLYSINE
CARG2-THR3M3L: N-TRIMETHYLLYSINE
CGLN5-THR6M3L: N-TRIMETHYLLYSINE

M3L_4uy4_D_411N-TRIMETHYLLYSINE binding site
ChainResidueligand
BPHE127-GLU128M3L: N-TRIMETHYLLYSINE
BTRP137M3L: N-TRIMETHYLLYSINE
BTYR156M3L: N-TRIMETHYLLYSINE
BASP159M3L: N-TRIMETHYLLYSINE
BTYR163M3L: N-TRIMETHYLLYSINE
BTYR165M3L: N-TRIMETHYLLYSINE
DARG2-THR3M3L: N-TRIMETHYLLYSINE
DGLN5-THR6M3L: N-TRIMETHYLLYSINE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI12Histone H3K4me3 and H3R8me2a. {ECO:0000250|UniProtKB:Q9Y657}.
ChainResidueDetails
AASP126
AASP137

SWS_FT_FI22Histone H3K4me3 and H3R8me2a. {ECO:0000250|UniProtKB:Q9Y657}.
ChainResidueDetails
BASP126
BASP137

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Catalytic Information from CSA

site_idNumber of ResiduesDetails