4UXR

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003725	molecular_function	double-stranded RNA binding
A	0003924	molecular_function	GTPase activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0046872	molecular_function	metal ion binding
A	0071353	biological_process	cellular response to interleukin-4
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0007399	biological_process	nervous system development
B	0015630	cellular_component	microtubule cytoskeleton
B	0046872	molecular_function	metal ion binding
B	0046982	molecular_function	protein heterodimerization activity
B	1902669	biological_process	positive regulation of axon guidance
C	0003777	molecular_function	microtubule motor activity
C	0005524	molecular_function	ATP binding
C	0007018	biological_process	microtubule-based movement
C	0008017	molecular_function	microtubule binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	HIS256

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 502

Chain	Residue
A	GTP1413

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site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GTP A 1413

Chain	Residue
A	THR118
A	MG502
A	GLY9
A	GLN10
A	ALA11
A	ALA72
A	ASN74
A	GLY116
A	GLY117

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GDP B 1427

Chain	Residue
B	GLY9
B	CYS11
B	THR142
B	GLY143

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TA1 B 1428

Chain	Residue
B	VAL22
B	LEU272
B	ARG275
B	PRO357
B	ARG358

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ADP C 1361

Chain	Residue
C	GLY102
C	SER104
C	MG1362
C	ALF1363

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 1362

Chain	Residue
C	ADP1361
C	ALF1363

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ALF C 1363

Chain	Residue
C	SER214
C	ALA250
C	GLY251
C	ADP1361
C	MG1362

---

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY139-GLY145
A	GLY115-GLY121

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET0-ILE3

---

site_id	PS00411
Number of Residues	12
Details	KINESIN_MOTOR_1 Kinesin motor domain signature. SKIsLVDLAGSE

Chain	Residue	Details
C	SER242-GLU253

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00283

Chain	Residue	Details
C	GLY97
B	SER137
B	GLY141
B	THR142
B	GLY143
B	ASN203
B	ASN225

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P68363

Chain	Residue	Details
B	GLU68
A	GLU44
A	SER113
A	GLY117
A	THR118
A	THR152
A	ASN179
A	ASN201

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99024

Chain	Residue	Details
B	SER39

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q3KRE8

Chain	Residue	Details
B	ALA54

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024

Chain	Residue	Details
B	LYS57
A	GLY205

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q9BVA1

Chain	Residue	Details
B	SER171

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	THR284
B	THR289

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	ARG317

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0

Chain	Residue	Details
B	GLU437

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	LYS57

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
A	TYR424
B	LYS323

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P68363

Chain	Residue	Details
A	LYS299
A	LYS343

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