Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4UXA

Improved variant of (R)-selective manganese-dependent hydroxynitrile lyase from bacteria

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
C	0016829	molecular_function	lyase activity
C	0046872	molecular_function	metal ion binding
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding
E	0016829	molecular_function	lyase activity
E	0046872	molecular_function	metal ion binding
F	0016829	molecular_function	lyase activity
F	0046872	molecular_function	metal ion binding
G	0016829	molecular_function	lyase activity
G	0046872	molecular_function	metal ion binding
H	0016829	molecular_function	lyase activity
H	0046872	molecular_function	metal ion binding
I	0016829	molecular_function	lyase activity
I	0046872	molecular_function	metal ion binding
J	0016829	molecular_function	lyase activity
J	0046872	molecular_function	metal ion binding
K	0016829	molecular_function	lyase activity
K	0046872	molecular_function	metal ion binding
L	0016829	molecular_function	lyase activity
L	0046872	molecular_function	metal ion binding
M	0016829	molecular_function	lyase activity
M	0046872	molecular_function	metal ion binding
N	0016829	molecular_function	lyase activity
N	0046872	molecular_function	metal ion binding
O	0016829	molecular_function	lyase activity
O	0046872	molecular_function	metal ion binding
P	0016829	molecular_function	lyase activity
P	0046872	molecular_function	metal ion binding
Q	0016829	molecular_function	lyase activity
Q	0046872	molecular_function	metal ion binding
R	0016829	molecular_function	lyase activity
R	0046872	molecular_function	metal ion binding
S	0016829	molecular_function	lyase activity
S	0046872	molecular_function	metal ion binding
T	0016829	molecular_function	lyase activity
T	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 200

Chain	Residue
A	HIS53
A	HIS55
A	GLN59
A	HIS94
A	HIS96
A	HOH2045

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 200

Chain	Residue
B	HIS94
B	HIS96
B	HOH2055
B	HIS53
B	HIS55
B	GLN59

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 200

Chain	Residue
C	HIS53
C	HIS55
C	GLN59
C	HIS94
C	HIS96
C	HOH2051

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 200

Chain	Residue
D	HIS53
D	HIS55
D	GLN59
D	HIS94
D	HIS96
D	HOH2064

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 200

Chain	Residue
E	HIS53
E	HIS55
E	GLN59
E	HIS94
E	HIS96
E	HOH2039

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 200

Chain	Residue
F	HIS53
F	HIS55
F	GLN59
F	HIS94
F	HIS96
F	HOH2048

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 200

Chain	Residue
G	HIS53
G	HIS55
G	GLN59
G	HIS94
G	HIS96
G	HOH2041

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN H 200

Chain	Residue
H	HIS53
H	HIS55
H	GLN59
H	HIS94
H	HIS96
H	HOH2044

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN I 200

Chain	Residue
I	HIS53
I	HIS55
I	GLN59
I	HIS94
I	HIS96
I	HOH2044

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN J 200

Chain	Residue
J	HIS53
J	HIS55
J	GLN59
J	HIS94
J	HIS96
J	HOH2036

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN K 200

Chain	Residue
K	HIS53
K	HIS55
K	GLN59
K	HIS94
K	HIS96
K	HOH2055

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN L 200

Chain	Residue
L	HIS53
L	HIS55
L	GLN59
L	HIS94
L	HIS96
L	HOH2045

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN M 200

Chain	Residue
M	HIS53
M	HIS55
M	GLN59
M	HIS94
M	HIS96
M	HOH2043

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN N 200

Chain	Residue
N	HIS53
N	HIS55
N	GLN59
N	HIS94
N	HIS96
N	HOH2046

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN O 200

Chain	Residue
O	HIS53
O	HIS55
O	GLN59
O	HIS94
O	HIS96
O	HOH2042

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN P 200

Chain	Residue
P	HIS53
P	HIS55
P	GLN59
P	HIS94
P	HIS96
P	HOH2045

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN Q 200

Chain	Residue
Q	HIS94
Q	HIS96
Q	HOH2035
Q	HIS53
Q	HIS55
Q	GLN59

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN R 200

Chain	Residue
R	HIS53
R	HIS55
R	GLN59
R	HIS94
R	HIS96
R	HOH2040

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN S 200

Chain	Residue
S	HIS53
S	HIS55
S	GLN59
S	HIS94
S	HIS96
S	HOH2026

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN T 200

Chain	Residue
T	HIS53
T	HIS55
T	GLN59
T	HIS94
T	HIS96
T	HOH2030

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	BINDING: BINDING => ECO:0000269\|PubMed:23981508, ECO:0000269\|DOI:10.1002/CCTC.201402742, ECO:0007744\|PDB:4BIF, ECO:0007744\|PDB:4UXA

Chain	Residue	Details
A	HIS53
B	HIS96
T	HIS96
C	HIS53
C	HIS55
C	GLN59
C	HIS94
C	HIS96
D	HIS53
D	HIS55
D	GLN59
D	HIS94
A	HIS55
D	HIS96
E	HIS53
E	HIS55
E	GLN59
E	HIS94
E	HIS96
F	HIS53
F	HIS55
F	GLN59
F	HIS94
A	GLN59
F	HIS96
G	HIS53
G	HIS55
G	GLN59
G	HIS94
G	HIS96
H	HIS53
H	HIS55
H	GLN59
H	HIS94
A	HIS94
H	HIS96
I	HIS53
I	HIS55
I	GLN59
I	HIS94
I	HIS96
J	HIS53
J	HIS55
J	GLN59
J	HIS94
A	HIS96
J	HIS96
K	HIS53
K	HIS55
K	GLN59
K	HIS94
K	HIS96
L	HIS53
L	HIS55
L	GLN59
L	HIS94
B	HIS53
L	HIS96
M	HIS53
M	HIS55
M	GLN59
M	HIS94
M	HIS96
N	HIS53
N	HIS55
N	GLN59
N	HIS94
B	HIS55
N	HIS96
O	HIS53
O	HIS55
O	GLN59
O	HIS94
O	HIS96
P	HIS53
P	HIS55
P	GLN59
P	HIS94
B	GLN59
P	HIS96
Q	HIS53
Q	HIS55
Q	GLN59
Q	HIS94
Q	HIS96
R	HIS53
R	HIS55
R	GLN59
R	HIS94
B	HIS94
R	HIS96
S	HIS53
S	HIS55
S	GLN59
S	HIS94
S	HIS96
T	HIS53
T	HIS55
T	GLN59
T	HIS94

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)