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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4UX9

Crystal structure of JNK1 bound to a MKK7 docking motif

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004707	molecular_function	MAP kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004707	molecular_function	MAP kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004707	molecular_function	MAP kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP A 1000

Chain	Residue
A	ILE32
A	ILE86
A	MET108
A	GLU109
A	MET111
A	ASN114
A	SER155
A	ASN156
A	LEU168
A	GLY33
A	SER34
A	GLY35
A	ALA36
A	GLY38
A	VAL40
A	ALA53
A	LYS55

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP B 1000

Chain	Residue
B	ILE32
B	GLY33
B	SER34
B	VAL40
B	ALA53
B	LYS55
B	MET108
B	GLU109
B	MET111
B	ASN114
B	ASP151
B	LYS153
B	SER155
B	ASN156
B	LEU168
B	ASP169

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ANP C 1000

Chain	Residue
C	ILE32
C	GLY33
C	SER34
C	GLY35
C	GLN37
C	GLY38
C	VAL40
C	ALA53
C	LYS55
C	ILE86
C	GLU109
C	MET111
C	ASN114
C	SER155
C	ASN156
C	LEU168
C	ASP169
C	HOH2060

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ANP D 1000

Chain	Residue
D	ILE32
D	VAL40
D	ALA53
D	MET108
D	GLU109
D	MET111
D	ASN114
D	LYS153
D	SER155
D	ASN156
D	LEU168
D	HOH2069

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1364

Chain	Residue
A	SO41366
C	ARG263
D	ARG263

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1363

Chain	Residue
B	ARG72
B	ARG150
B	ARG174

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1364

Chain	Residue
A	LYS68
A	ARG72
A	ARG150
A	ARG174

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1364

Chain	Residue
B	ARG25
B	LEU48

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 1049

Chain	Residue
A	LYS30
H	ARG38
H	ARG40

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1365

Chain	Residue
A	ARG189
A	ARG192
A	TYR230
A	HOH2039
B	THR255

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1365

Chain	Residue
D	ARG174
D	GLY177
D	THR178
D	SER179

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1365

Chain	Residue
B	LYS250
B	ARG257

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1365

Chain	Residue
C	LYS153
C	SER155
C	HOH2013

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1366

Chain	Residue
C	ARG189
C	ARG192
C	TYR230
C	HOH2016
C	HOH2030
D	THR255

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1367

Chain	Residue
C	ARG150
C	ARG174
C	ARG72

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1366

Chain	Residue
D	THR65
D	LYS68
D	ARG69
D	ARG72
D	ARG150
D	ARG174

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1366

Chain	Residue
A	THR255
A	HOH2050
B	ARG189
B	ARG192
B	TYR230

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 1367

Chain	Residue
D	ARG25
D	LEU48

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1366

Chain	Residue
A	ARG263
B	ARG263
C	SO41364

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1367

Chain	Residue
A	GLU239
A	ALA267
A	GLY268
A	TYR269
D	ARG228

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV

Chain	Residue	Details
A	ILE147-VAL159

site_id	PS01351
Number of Residues	103
Details	MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC

Chain	Residue	Details
A	PHE61-CYS163

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Cleavage; by anthrax lethal factor

Chain	Residue	Details
F	GLN44
G	GLN44
H	GLN44
I	GLN44

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
C	ILE32
C	LYS55
D	ILE32
D	LYS55
A	ILE32
A	LYS55
B	ILE32
B	LYS55

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250\|UniProtKB:P49185

Chain	Residue	Details
A	CYS116
B	CYS116
C	CYS116
D	CYS116

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by MAP2K7 => ECO:0000269\|PubMed:11062067

Chain	Residue	Details
A	THR183
B	THR183
C	THR183
D	THR183

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by MAP2K4 => ECO:0000269\|PubMed:11062067

Chain	Residue	Details
A	TYR185
B	TYR185
C	TYR185
D	TYR185

219869

PDB entries from 2024-05-15

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