4UWC
Fibroblast growth factor receptor 1 kinase in complex with JK-P3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005007 | molecular_function | fibroblast growth factor receptor activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005007 | molecular_function | fibroblast growth factor receptor activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1765 |
| Chain | Residue |
| B | ASN628 |
| B | ASP641 |
| B | EDO1769 |
| B | 4Y01770 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1766 |
| Chain | Residue |
| A | 4Y01773 |
| A | HOH2021 |
| A | GLU531 |
| A | ALA640 |
| A | ASP641 |
| A | PHE642 |
| A | GLY643 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1767 |
| Chain | Residue |
| A | TRP684 |
| A | TYR701 |
| A | ARG718 |
| A | MET719 |
| A | TRP737 |
| A | HOH2091 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1766 |
| Chain | Residue |
| B | GLU531 |
| B | ALA640 |
| B | ASP641 |
| B | PHE642 |
| B | GLY643 |
| B | 4Y01770 |
| B | HOH2027 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1767 |
| Chain | Residue |
| B | TRP684 |
| B | TYR701 |
| B | ARG718 |
| B | MET719 |
| B | TRP737 |
| B | HOH2116 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1768 |
| Chain | Residue |
| B | PRO466 |
| B | ILE529 |
| B | GLU533 |
| B | THR552 |
| B | HOH2044 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1768 |
| Chain | Residue |
| A | ALA615 |
| A | THR746 |
| A | PHE747 |
| A | LYS748 |
| A | HOH2164 |
| A | HOH2165 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1769 |
| Chain | Residue |
| A | ARG470 |
| A | TRP471 |
| A | SO41777 |
| A | SO41779 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1769 |
| Chain | Residue |
| B | ASN568 |
| B | ARG627 |
| B | EDO1765 |
| B | 4Y01770 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 1770 |
| Chain | Residue |
| A | LYS714 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1771 |
| Chain | Residue |
| A | TYR572 |
| A | LEU595 |
| A | ASP599 |
| A | GLN606 |
| A | ASN635 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1772 |
| Chain | Residue |
| A | LYS665 |
| A | GLY703 |
| A | VAL704 |
| A | HOH2108 |
| site_id | BC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 4Y0 A 1773 |
| Chain | Residue |
| A | LEU484 |
| A | ILE545 |
| A | VAL561 |
| A | GLU562 |
| A | TYR563 |
| A | ALA564 |
| A | SER565 |
| A | GLY567 |
| A | GLU571 |
| A | LEU630 |
| A | EDO1766 |
| A | PPI1775 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 4Y0 B 1770 |
| Chain | Residue |
| B | VAL492 |
| B | VAL561 |
| B | GLU562 |
| B | TYR563 |
| B | ALA564 |
| B | SER565 |
| B | GLY567 |
| B | GLU571 |
| B | LEU630 |
| B | EDO1765 |
| B | EDO1766 |
| B | EDO1769 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PPI A 1774 |
| Chain | Residue |
| A | ARG577 |
| A | GLY698 |
| A | SER699 |
| B | HIS717 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PPI B 1771 |
| Chain | Residue |
| B | SER597 |
| B | PHE694 |
| B | ASN724 |
| B | CYS725 |
| B | THR726 |
| B | LEU729 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PPI A 1775 |
| Chain | Residue |
| A | LYS566 |
| A | TYR572 |
| A | ARG576 |
| A | 4Y01773 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1776 |
| Chain | Residue |
| A | THR657 |
| A | ASN659 |
| A | ARG661 |
| A | HOH2076 |
| A | HOH2166 |
| A | ARG570 |
| A | ARG627 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1772 |
| Chain | Residue |
| B | ARG570 |
| B | ARG627 |
| B | THR657 |
| B | ASN659 |
| B | ARG661 |
| B | HOH2095 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1777 |
| Chain | Residue |
| A | ARG470 |
| A | TRP471 |
| A | GLU472 |
| A | LEU500 |
| A | LEU548 |
| A | GLY549 |
| A | EDO1769 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1778 |
| Chain | Residue |
| A | GLY539 |
| A | LYS540 |
| A | LYS618 |
| A | HOH2031 |
| A | HOH2167 |
| A | HOH2168 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1773 |
| Chain | Residue |
| A | SER584 |
| A | TYR585 |
| B | ARG734 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1779 |
| Chain | Residue |
| A | ARG470 |
| A | LYS618 |
| A | HIS679 |
| A | EDO1769 |
| A | HOH2004 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 31 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK |
| Chain | Residue | Details |
| A | LEU484-LYS514 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV |
| Chain | Residue | Details |
| A | CYS619-VAL631 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19665973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
