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4UTR

Crystal structure of zebrafish Sirtuin 5 in complex with glutarylated CPS1-peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0036054molecular_functionprotein-malonyllysine demalonylase activity
A0036055molecular_functionprotein-succinyllysine desuccinylase activity
A0070403molecular_functionNAD+ binding
B0036054molecular_functionprotein-malonyllysine demalonylase activity
B0036055molecular_functionprotein-succinyllysine desuccinylase activity
B0070403molecular_functionNAD+ binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GUA C 1299
ChainResidue
ATYR98
AARG101
AVAL217
APHE219
CLYS4

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1299
ChainResidue
BCYS162
BCYS165
BCYS203
BCYS208

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1300
ChainResidue
ACYS162
ACYS165
ACYS203
ACYS208

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1301
ChainResidue
AGLN136
AASN137
AILE138
AASP139

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO B 1300
ChainResidue
BGLU232
BGLU236
BGLN259
BARG263

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE EDO A 1302
ChainResidue
AGLU232
BVAL217

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE DMS B 1301
ChainResidue
AARG144
AALA145
BARG144
BALA145
BGLY146

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NA B 1302
ChainResidue
BASP224
BASP224
BASP226
BASP226

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8C196
ChainResidueDetails
CLYS4
BHIS154

site_idSWS_FT_FI2
Number of Residues22
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160
ChainResidueDetails
AGLY54
AASN271
ACYS289
BGLY54
BTYR98
BARG101
BGLN136
BCYS162
BCYS165
BCYS203
BCYS208
ATYR98
BGLY245
BASN271
BCYS289
AARG101
AGLN136
ACYS162
ACYS165
ACYS203
ACYS208
AGLY245

226707

PDB entries from 2024-10-30

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