4UP2
Crystal structure of Escherichia coli tryptophanase purified from alkaline stressed bacterial culture.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006568 | biological_process | tryptophan metabolic process |
| A | 0006569 | biological_process | tryptophan catabolic process |
| A | 0009034 | molecular_function | tryptophanase activity |
| A | 0009072 | biological_process | aromatic amino acid metabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016830 | molecular_function | carbon-carbon lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006568 | biological_process | tryptophan metabolic process |
| B | 0006569 | biological_process | tryptophan catabolic process |
| B | 0009034 | molecular_function | tryptophanase activity |
| B | 0009072 | biological_process | aromatic amino acid metabolic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016830 | molecular_function | carbon-carbon lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006568 | biological_process | tryptophan metabolic process |
| C | 0006569 | biological_process | tryptophan catabolic process |
| C | 0009034 | molecular_function | tryptophanase activity |
| C | 0009072 | biological_process | aromatic amino acid metabolic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016830 | molecular_function | carbon-carbon lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006568 | biological_process | tryptophan metabolic process |
| D | 0006569 | biological_process | tryptophan catabolic process |
| D | 0009034 | molecular_function | tryptophanase activity |
| D | 0009072 | biological_process | aromatic amino acid metabolic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016830 | molecular_function | carbon-carbon lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1469 |
| Chain | Residue |
| A | SER54 |
| A | GLN101 |
| A | GLY102 |
| A | ARG103 |
| A | SER267 |
| A | LYS269 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1470 |
| Chain | Residue |
| B | GLY55 |
| B | PRO275 |
| A | GLU72 |
| A | LEU310 |
| B | SER54 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1471 |
| Chain | Residue |
| A | VAL388 |
| A | ALA389 |
| A | PHE434 |
| A | GLU437 |
| A | ALA438 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1455 |
| Chain | Residue |
| A | MET1 |
| C | VAL388 |
| C | ALA389 |
| C | PHE434 |
| C | GLU437 |
| C | ALA438 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1472 |
| Chain | Residue |
| A | THR23 |
| A | ARG24 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1473 |
| Chain | Residue |
| A | ALA84 |
| A | GLN94 |
| A | HOH2018 |
| A | HOH2039 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1474 |
| Chain | Residue |
| A | THR52 |
| A | ASP53 |
| A | LYS270 |
| A | ARG419 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1454 |
| Chain | Residue |
| A | GLY55 |
| A | PRO275 |
| B | GLU72 |
| B | LEU310 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1455 |
| Chain | Residue |
| B | TRP248 |
| B | GLN252 |
| B | HOH2029 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1456 |
| Chain | Residue |
| B | TYR74 |
| B | TYR307 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1457 |
| Chain | Residue |
| B | TYR307 |
| B | HOH2030 |
| B | HOH2031 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1458 |
| Chain | Residue |
| B | GLY102 |
| B | ARG103 |
| B | SER267 |
| B | LYS269 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1455 |
| Chain | Residue |
| B | GLU2 |
| D | VAL388 |
| D | ALA389 |
| D | PHE434 |
| D | GLU437 |
| D | ALA438 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1459 |
| Chain | Residue |
| B | THR60 |
| B | SER62 |
| B | ASP324 |
| B | HOH2023 |
| D | PRO18 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1460 |
| Chain | Residue |
| B | THR22 |
| B | THR23 |
| B | ARG24 |
| B | ARG27 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME B 1461 |
| Chain | Residue |
| B | SER75 |
| B | GLY76 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1456 |
| Chain | Residue |
| C | GLN101 |
| C | GLY102 |
| C | ARG103 |
| C | SER267 |
| C | LYS269 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1457 |
| Chain | Residue |
| C | THR52 |
| C | LYS270 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1458 |
| Chain | Residue |
| C | THR22 |
| C | THR23 |
| C | ARG24 |
| C | ARG27 |
| C | HOH2004 |
| C | HOH2024 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1456 |
| Chain | Residue |
| C | GLU72 |
| D | SER54 |
| D | GLY55 |
| D | LYS269 |
| D | PRO275 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1459 |
| Chain | Residue |
| C | GLN94 |
| C | HOH2011 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1460 |
| Chain | Residue |
| C | SER398 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1461 |
| Chain | Residue |
| B | LYS211 |
| C | LYS211 |
| C | GLU244 |
| C | TYR245 |
| C | GLU256 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1462 |
| Chain | Residue |
| C | PRO414 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1457 |
| Chain | Residue |
| C | SER54 |
| C | GLY55 |
| D | GLU72 |
| D | ALA73 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1458 |
| Chain | Residue |
| D | SER267 |
| D | LYS269 |
| D | GLN101 |
| D | GLY102 |
| D | ARG103 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1459 |
| Chain | Residue |
| C | GLN101 |
| D | LEU310 |
| site_id | DC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1460 |
| Chain | Residue |
| D | LEU452 |
| D | THR453 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1462 |
| Chain | Residue |
| B | VAL388 |
| B | PHE434 |
| B | GLU437 |
| B | ALA438 |
| D | GLU2 |
Functional Information from PROSITE/UniProt
| site_id | PS00853 |
| Number of Residues | 19 |
| Details | BETA_ELIM_LYASE Beta-eliminating lyases pyridoxal-phosphate attachment site. YaDmlaMSAKKDaMVpMGG |
| Chain | Residue | Details |
| A | TYR260-GLY278 |
