4UJ5

Crystal structure of human Rab11-Rabin8-FIP3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GNP A 201

Chain	Residue
A	SER20
A	LEU38
A	SER40
A	SER42
A	THR43
A	ALA68
A	GLY69
A	ASN124
A	LYS125
A	ASP127
A	LEU128
A	GLY21
A	SER154
A	ALA155
A	LEU156
A	MG202
A	HOH2006
A	HOH2007
A	HOH2027
C	TYR423
A	VAL22
A	GLY23
A	LYS24
A	SER25
A	ASN26
A	PHE36
A	ASN37

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	SER25
A	THR43
A	ASP66
A	GNP201
A	HOH2006
A	HOH2007

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	ASP92
A	ALA94
A	LYS95
A	LYS125

---

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GNP B 201

Chain	Residue
B	SER20
B	GLY21
B	VAL22
B	GLY23
B	LYS24
B	SER25
B	ASN26
B	PHE36
B	ASN37
B	LEU38
B	SER40
B	SER42
B	THR43
B	THR67
B	ALA68
B	GLY69
B	ASN124
B	LYS125
B	ASP127
B	LEU128
B	SER154
B	ALA155
B	LEU156
B	MG202
B	HOH2006
B	HOH2007
D	TYR423

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 202

Chain	Residue
B	SER25
B	THR43
B	GNP201
B	HOH2006
B	HOH2007

---

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. KEEL

Chain	Residue	Details
C	LYS457-LEU460

---

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VVLiGDSGVGKsnL

Chain	Residue	Details
A	VAL14-LEU27

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15837192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) N-beta-linked (GlcNAc) arginine","evidences":[{"source":"PubMed","id":"32974215","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	19
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	18
Details	Region: {"description":"Important for RAB11A binding","evidences":[{"source":"PubMed","id":"26258637","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---