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4UAI

Crystal structure of CXCL12 in complex with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001764biological_processneuron migration
A0001938biological_processpositive regulation of endothelial cell proliferation
A0005102molecular_functionsignaling receptor binding
A0005125molecular_functioncytokine activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006874biological_processintracellular calcium ion homeostasis
A0006935biological_processchemotaxis
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007411biological_processaxon guidance
A0008009molecular_functionchemokine activity
A0008015biological_processblood circulation
A0008064biological_processregulation of actin polymerization or depolymerization
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0008344biological_processadult locomotory behavior
A0009612biological_processresponse to mechanical stimulus
A0009615biological_processresponse to virus
A0009897cellular_componentexternal side of plasma membrane
A0022029biological_processtelencephalon cell migration
A0030335biological_processpositive regulation of cell migration
A0031012cellular_componentextracellular matrix
A0031100biological_processanimal organ regeneration
A0033603biological_processpositive regulation of dopamine secretion
A0033622biological_processintegrin activation
A0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
A0038160biological_processCXCL12-activated CXCR4 signaling pathway
A0042379molecular_functionchemokine receptor binding
A0043434biological_processresponse to peptide hormone
A0045236molecular_functionCXCR chemokine receptor binding
A0045666biological_processpositive regulation of neuron differentiation
A0045785biological_processpositive regulation of cell adhesion
A0048842biological_processpositive regulation of axon extension involved in axon guidance
A0050921biological_processpositive regulation of chemotaxis
A0050930biological_processinduction of positive chemotaxis
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0051924biological_processregulation of calcium ion transport
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0070098biological_processchemokine-mediated signaling pathway
A0090026biological_processpositive regulation of monocyte chemotaxis
A0090280biological_processpositive regulation of calcium ion import
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1903237biological_processnegative regulation of leukocyte tethering or rolling
A1904018biological_processpositive regulation of vasculature development
A1990478biological_processresponse to ultrasound
A1990869biological_processcellular response to chemokine
A2000406biological_processpositive regulation of T cell migration
A2000669biological_processnegative regulation of dendritic cell apoptotic process
B0001666biological_processresponse to hypoxia
B0001764biological_processneuron migration
B0001938biological_processpositive regulation of endothelial cell proliferation
B0005102molecular_functionsignaling receptor binding
B0005125molecular_functioncytokine activity
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006874biological_processintracellular calcium ion homeostasis
B0006935biological_processchemotaxis
B0006955biological_processimmune response
B0007155biological_processcell adhesion
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007411biological_processaxon guidance
B0008009molecular_functionchemokine activity
B0008015biological_processblood circulation
B0008064biological_processregulation of actin polymerization or depolymerization
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0008344biological_processadult locomotory behavior
B0009612biological_processresponse to mechanical stimulus
B0009615biological_processresponse to virus
B0009897cellular_componentexternal side of plasma membrane
B0022029biological_processtelencephalon cell migration
B0030335biological_processpositive regulation of cell migration
B0031012cellular_componentextracellular matrix
B0031100biological_processanimal organ regeneration
B0033603biological_processpositive regulation of dopamine secretion
B0033622biological_processintegrin activation
B0038146biological_processchemokine (C-X-C motif) ligand 12 signaling pathway
B0038160biological_processCXCL12-activated CXCR4 signaling pathway
B0042379molecular_functionchemokine receptor binding
B0043434biological_processresponse to peptide hormone
B0045236molecular_functionCXCR chemokine receptor binding
B0045666biological_processpositive regulation of neuron differentiation
B0045785biological_processpositive regulation of cell adhesion
B0048842biological_processpositive regulation of axon extension involved in axon guidance
B0050921biological_processpositive regulation of chemotaxis
B0050930biological_processinduction of positive chemotaxis
B0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
B0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
B0051924biological_processregulation of calcium ion transport
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0070098biological_processchemokine-mediated signaling pathway
B0090026biological_processpositive regulation of monocyte chemotaxis
B0090280biological_processpositive regulation of calcium ion import
B1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
B1903237biological_processnegative regulation of leukocyte tethering or rolling
B1904018biological_processpositive regulation of vasculature development
B1990478biological_processresponse to ultrasound
B1990869biological_processcellular response to chemokine
B2000406biological_processpositive regulation of T cell migration
B2000669biological_processnegative regulation of dendritic cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue 3GG A 101
ChainResidue
AARG8
AGLU15
AALA19
AASN22
ALEU42
AASN45
AARG47
AVAL49

site_idAC2
Number of Residues7
Detailsbinding site for residue SO4 A 102
ChainResidue
AVAL3
ASER4
AALA19
AARG20
AALA21
AHOH201
APRO2

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 B 101
ChainResidue
BARG41
BARG47
BGLN48

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsRegion: {"description":"Receptor and heparin binding","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues28
DetailsRegion: {"description":"Receptor binding"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsMotif: {"description":"Receptor activation motif"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues26
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues6
DetailsSite: {"description":"Important for integrin interaction and activation","evidences":[{"source":"PubMed","id":"29301984","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsSite: {"description":"Important for dimer formation"}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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