4U8H
Crystal Structure of Mammalian Period-Cryptochrome Complex
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 2000 |
| Chain | Residue |
| A | CYS432 |
| A | HIS491 |
| B | CYS1210 |
| B | TYR1212 |
| B | CYS1213 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 2000 |
| Chain | Residue |
| D | TYR1212 |
| D | CYS1213 |
| A | ARG460 |
| C | CYS432 |
| C | HIS491 |
| D | CYS1210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 258 |
| Details | Domain: {"description":"Photolyase/cryptochrome alpha/beta"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 198 |
| Details | Region: {"description":"Required for inhibition of CLOCK-BMAL1-mediated transcription","evidences":[{"source":"UniProtKB","id":"P97784","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23503662","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P97784","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P97784","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK","evidences":[{"source":"PubMed","id":"11875063","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15298678","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P97784","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23452856","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
